Antibody therapeutics have become one of the most successful classes of biologic drugs in modern medicine. Over the past two decades, they have fundamentally reshaped the treatment landscape for cancer, autoimmune diseases, and beyond. Yet, for those working in antibody discovery, development, or manufacturing, it is increasingly clear that clinical success is not determined by target selection alone. Molecular format, functional design, and—critically—how an antibody is manufactured all play decisive roles in determining whether a candidate ultimately reaches patients.

Recent reports of Nipah virus (NiV) infection cases and fatalities in India have again drawn international attention to this deadly pathogen, which boasts a case fatality rate of 40-75%. Compared to the early Malaysian strain, the Indian circulating strain has acquired key mutations that may impact the efficacy of existing antibodies and vaccines. With no approved therapeutics or vaccines globally, containing this virus presents a severe challenge. AntibodySystem Leverages Cutting-Edge Findings to Offer Antigen and Antibody Development & Evaluation Solutions.

What truly causes confusion, however, is not what systems exist, but rather why the same gene can yield dramatically different results when expressed in different systems. The answer is actually quite straightforward: different expression systems differ greatly in their ability to properly “handle” a protein.

Without assuming prior experience, this tutorial walks you through a practical, reliable, and reproducible immunofluorescence workflow, from experimental setup to image acquisition.

ELISA (Enzyme-Linked Immunosorbent Assay) is one of the most commonly used protein quantification techniques in the lab, prized for its high sensitivity and specificity. However, behind its seemingly straightforward protocol lie numerous pitfalls that can lead to experimental failure. Whether it's weak signal, high background, or poor reproducibility, these issues are a major headache.

In September 2025, a research paper titled "Targeting necrotic lipid release in tumors enhances immunosurveillance and cancer immunotherapy of glioblastoma" in the journal Cell Research. This study reveals for the first time a novel immune evasion mechanism whereby loss of pro-apoptotic tumor suppressor genes (such as TP53) triggers mPTP-dependent necrosis, releasing APOE-containing lipid particles that lead to T cell dysfunction. Furthermore, it proposes that clearing excess APOE lipid particles from the immune microenvironment is a new strategy to restore the function of tumor-infiltrating T cells and enhance the efficacy of immunotherapy for glioblastoma (GBM).

Recent reports of Nipah virus (NiV) infections in India have once again drawn global attention to this highly lethal zoonotic pathogen. Despite its relatively low incidence, NiV is associated with case fatality rates of up to 75%, strong neurotropism, and the absence of licensed vaccines or specific antiviral therapies. As a result, Nipah virus remains a WHO priority pathogen, requiring sustained efforts in fundamental virology, immunology, and diagnostic development.

On World Leprosy Day, focusing not only on the disease itself but also on scientific research and technological advances is a vital force in driving the eventual elimination of leprosy. AntibodySystem remains committed to supporting global researchers in the field of leprosy and related immune diseases with high-quality products.

January 13th, 2026, a study published in Cell Stem Cell has drawn significant attention from the reproductive medicine and stem cell research communities. In the article entitled “Development of human induced pluripotent stem cell-derived ovarian support cells as a clinical-grade product for in vitro fertilization,” researchers from Gameto report the development of ovarian support cells (OSCs) derived from human induced pluripotent stem cells (hiPSCs) and their translation into a clinical-grade product for assisted reproduction.

In December 2025, multiple AntibodySystem products were cited in high-impact international journals, including Nature Communications and Advanced Science. These studies span cutting-edge research areas such as the pathogenicity and immune evasion of SARS-CoV-2 JN.1-derived variants, anti-tumor mechanisms of marine terpenoids targeting UBE2C, development of influenza/COVID-19 hybrid vaccines, regulation of erythropoiesis, and precision vaccine design for osteoporosis.

Recently, multiple regions in Japan have reported a sustained increase in syphilis cases, with annual confirmed infections exceeding 13,000 for four consecutive years. Epidemiological data indicate a clear shift toward younger populations, alongside a notable rise in cases among women. Once regarded as a “controllable and curable” sexually transmitted infection, syphilis is re-emerging in a more insidious and complex form, underscoring the need to move beyond textbook-level understanding of this disease.

A recent study published in Nature, entitled “Sustained HIV-1 remission after heterozygous CCR5Δ32 stem cell transplantation,” reports a case of long-term HIV-1 remission in a patient who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) from a donor carrying a heterozygous CCR5Δ32 mutation.

For researchers new to hPSC-based neural differentiation, the most common challenge is not technical execution, but understanding why specific factors are added at each stage. At its core, neural differentiation of human pluripotent stem cells is a process of artificially recreating defined signaling environments, allowing cells to receive the right developmental cues at the right time. Understanding the function of these cues is far more important than memorizing differentiation recipes.

Cervical cancer ranks as the fourth most common cancer among women globally and is caused by persistent infection with the Human Papillomavirus (HPV), a small DNA virus known to infect the skin, genital areas, and throat. Based on disease severity, HPV is categorized into low-risk and high-risk types. Persistent infection with high-risk HPV, particularly types 16 and 18, is responsible for 70% of cervical cancer cases due to their potential to cause malignant tumors.

Glycosylation is a common post-translational modification in eukaryotic cells that plays a crucial role in protein folding, stability, activity, and intercellular signaling.

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The recent surge in bispecific antibodies