Catalog No.
YHE99101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu231-Leu463
Predicted molecular weight
28.34 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P53634
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Dipeptidyl peptidase 1, Dipeptidyl peptidase I exclusion domain chain, DPPI, Cathepsin J, Dipeptidyl transferase, Dipeptidyl peptidase I heavy chain, CTSC, Dipeptidyl peptidase I, Dipeptidyl peptidase I light chain, CPPI, Cathepsin C, DPP-I
Cathepsin C correlates with M2 macrophage infiltration and regulates the tumor growth and metastasis in non-small cell lung cancer., PMID:40474091
Effectiveness and Safety of Respiratory Syncytial Virus Vaccine for US Adults Aged 60 Years or Older., PMID:40343698
Inhibition of CTSC contributes to psoriasis inflammation and keratinocyte hyperproliferation by NF-κB signaling pathway., PMID:40339488
Immune Regulation and Disulfidptosis in Atherosclerosis Influence Disease Progression and Therapy., PMID:40299531
Identification of endocrine disrupting chemicals targeting NTD-related hub genes during pregnancy via in silico analysis., PMID:40187376
Neutrophil KLF2 regulates inflammasome-dependent neonatal mortality from endotoxemia., PMID:40170486
A Truncated Mutation of TP53 Promotes Chemoresistance in Tongue Squamous Cell Carcinoma., PMID:40076972
Multi-targeted olink proteomics analyses of cerebrospinal fluid from patients with aneurysmal subarachnoid hemorrhage., PMID:39604965
Increased expression of cathepsin C in airway epithelia exacerbates airway remodeling in asthma., PMID:39436705
Transplacental SARS-CoV-2 protein ORF8 binds to complement C1q to trigger fetal inflammation., PMID:39390219
Identification of novel indolinone derivatives as CTSC inhibitors to treat inflammatory bowel disease by modulating inflammatory factors., PMID:39383651
Cathepsin C Promotes Tumorigenesis in Bladder Cancer by Activating the Wnt/β-catenin Signalling Pathway., PMID:39344330
Cathepsin C (dipeptidyl peptidase 1) inhibition in adults with bronchiectasis: AIRLEAF, a phase II randomised, double-blind, placebo-controlled, dose-finding study., PMID:39255990
Novel cathepsin C inhibitor, BI 1291583, intended for treatment of bronchiectasis: Phase I characterization in healthy volunteers., PMID:39175217
[Single-cell transcriptomic sequencing coupled with Mendelian randomization analysis elucidates the pivotal role of CTSC in chronic rhinosinusitis]., PMID:38965845
Associations between multiple neurological biomarkers and distal sensorimotor polyneuropathy: KORA F4/FF4 study., PMID:38872492
Cathepsin C from extracellular histone-induced M1 alveolar macrophages promotes NETosis during lung ischemia-reperfusion injury., PMID:38861835
Targeting cathepsin C ameliorates murine acetaminophen-induced liver injury., PMID:38855187
Matrisome Transcriptome Dynamics during Tissue Aging., PMID:38792614
Deciphering smooth muscle cell heterogeneity in atherosclerotic plaques and constructing model: a multi-omics approach with focus on KLF15/IGFBP4 axis., PMID:38760675
Identification of PANoptosis-related subtypes, construction of a prognosis signature, and tumor microenvironment landscape of hepatocellular carcinoma using bioinformatic analysis and experimental verification., PMID:38742112
Rosmarinic acid alleviates toosendanin-induced liver injury through restoration of autophagic flux and lysosomal function by activating JAK2/STAT3/CTSC pathway., PMID:38631488
Toosendanin induces hepatotoxicity by restraining autophagy and lysosomal function through inhibiting STAT3/CTSC axis., PMID:38460807
Differential responses of selectively bred mussels (Perna canaliculus) to heat stress-survival, immunology, gene expression and microbiome diversity., PMID:38425477
Cathepsin C regulates tumor progression via the Yes-associated protein signaling pathway in non-small cell lung cancer., PMID:38323275
Papillon-Lefevre syndrome in twelve Egyptian patients: Five novel CTSC variants and functional characterization of a missense variant and its effect on splicing., PMID:38104461
A Systems Biology Approach for Investigating Significant Biomarkers and Drug Targets Common Among Patients with Gonorrhea, Chlamydia, and Prostate Cancer: A Pilot Study., PMID:38033384
Identification of novel diagnostic panel for mild cognitive impairment and Alzheimer's disease: findings based on urine proteomics and machine learning., PMID:37925455
CTSC promoted the migration and invasion of glioma cells via activation of STAT3/SERPINA3 axis., PMID:37925117
Expression and significance of cathepsin C and cathepsin D during pregnancy and Preeclampsia., PMID:37794357
The activation of SIRT1 by resveratrol reduces breast cancer metastasis to lung through inhibiting neutrophil extracellular traps., PMID:37772906
Periodontal Effects of the Reversible Dipeptidyl Peptidase 1 Inhibitor Brensocatib in Bronchiectasis., PMID:37746735
Characterizing the urinary proteome of prematurity-associated lung disease in school-aged children., PMID:37474963
Development and validation of asthma risk prediction models using co-expression gene modules and machine learning methods., PMID:37438356
Growth, immunity and transcriptome response to different stocking densities in Litopenaeus vannamei., PMID:37406891
Association of muscular strength and targeted proteomics involved in brain health in children with overweight/obesity., PMID:37190796
Abnormal expression of lysosomal glycoproteins in patients with congenital disorders of glycosylation., PMID:37069668
Cathepsin C promotes colorectal cancer metastasis by regulating immune escape through upregulating CSF1., PMID:36916928
Ceruloplasmin regulating fibrosis in orbital fibroblasts provides a novel therapeutic target for Graves' orbitopathy., PMID:36849849
Novel compound heterozygous mutation in CTSC gene with response to ustekinumab., PMID:36740595
Cardiorespiratory fitness and targeted proteomics involved in brain and cardiovascular health in children with overweight/obesity., PMID:36622372
F1 Male Sterility in Cattle-Yak Examined through Changes in Testis Tissue and Transcriptome Profiles., PMID:36230452
Regulatory T-cells-related signature for identifying a prognostic subtype of hepatocellular carcinoma with an exhausted tumor microenvironment., PMID:36189226
Dipeptidyl peptidase-1 inhibition in patients hospitalised with COVID-19: a multicentre, double-blind, randomised, parallel-group, placebo-controlled trial., PMID:36075243
Abnormal profiles of cathepsin C secreted in urine of Papillon Lefevre syndrome patients., PMID:36058494
Chitotriosidase 1 in the cerebrospinal fluid as a putative biomarker for HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) progression., PMID:36052089
Cathepsin C (CTSC) contributes to the antibacterial immunity in golden pompano (Trachinotus ovatus)., PMID:35952999
Introduction of mutant TP53 related genes in metabolic pathways and evaluation their correlation with immune cells, drug resistance and sensitivity., PMID:35667517
iTRAQ-based quantitative proteomic analysis of porcine uterine fluid during pre-implantation period of pregnancy., PMID:35354084
Multi-Design Differential Expression Profiling of COVID-19 Lung Autopsy Specimens Reveals Significantly Deregulated Inflammatory Pathways and SFTPC Impaired Transcription., PMID:35326463
For research use only. Not for human or drug use.
