Catalog No.
YHC88201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Ser250
Predicted molecular weight
32.47 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P11387
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
DNA topoisomerase 1, TOP1, DNA topoisomerase I
SRPS: Survival Reinforced Transfer Learning for Multicentric Proteomic Subtyping and Biomarker Discovery., PMID:40493767
The low endoribonuclease activity and lack of rNMP preference of human mitochondrial topoisomerase 1 protect against ribonucleotide-dependent deletions., PMID:40479709
Tyrosine and Phenylalanine Activate Neuronal DNA Repair but Exhibit Opposing Effects on Global Transcription and Adult Female Mice Are Resilient to TyrRS/YARS1 Depletion., PMID:40476370
New Dimethoxyaryl-Sesquiterpene Derivatives with Cytotoxic Activity Against MCF-7 Breast Cancer Cells: From Synthesis to Topoisomerase I/II Inhibition and Cell Death Mechanism Studies., PMID:40429684
Antitumor activity of topoisomerase I targeted by camptothecin 7-propionyl derivatives against ampullary carcinoma., PMID:40403499
A Rare Case of Systemic Sclerosis with Topo I Positivity and Anti-Topoisomerase I (Scl-70) Antibody Negativity., PMID:40387758
Virtual screening and molecular dynamics simulation study of ATP-competitive inhibitors targeting mTOR protein., PMID:40324009
The implication of non-AUG-initiated N-terminally extended proteoforms in cancer., PMID:40276932
Patulin and Xestoquinol are inhibitors of DNA topoisomerase 1., PMID:40273104
Progesterone Enhances Sensitivity of Ovarian Cancer Cells to SN38 Through Inhibition of Topoisomerase I and Inducing Ferroptosis., PMID:40270435
Assessing Structural Classification Using AlphaFold2 Models Through ECOD-Based Comparative Analysis., PMID:40251890
Prospective evaluation of plasma proteins in relation to surgical endometriosis diagnosis in the Nurses' Health Study II., PMID:40215752
HER2-targeted star polymer conjugates for improved tumor distribution and efficacy., PMID:40122243
Fork-barrier-independent roles of topoisomerase I in the ribosomal DNA., PMID:40119707
TOP1 Priority: Advancing Biomarker-Driven Patient Selection for the Use of ADCs., PMID:40095530
Preclinical evaluation of a novel antibody-drug conjugate OBI-992 for Cancer therapy., PMID:40082588
Unveiling the Mechanism of Action of Palmitic Acid, a Human Topoisomerase 1B Inhibitor from the Antarctic Sponge Artemisina plumosa., PMID:40076642
Candidate Key Proteins in Tinnitus-A Bioinformatic Study of Synaptic Transmission in the Inferior Colliculus., PMID:40076458
Application of a bivalent "click" approach to target tyrosyl-DNA phosphodiesterase 1 (TDP1)., PMID:39990162
Accurate Prediction of Protein Complex Stoichiometry by Integrating AlphaFold3 and Template Information., PMID:39975926
Topoisomerase 1 is required for the development and function of thymus., PMID:39959339
Elevated reactive oxygen species can drive the alternative lengthening of telomeres pathway in ATRX-null cancers., PMID:39921567
Comprehensive Evaluation of End-Point Free Energy Methods in DNA-Ligand Interaction Predictions., PMID:39888349
Exploiting synthetic lethality in PDAC with antibody drug conjugates and ATR inhibition., PMID:39874630
Accurate Prediction of Protein Complex Stoichiometry by Integrating AlphaFold3 and Template Information., PMID:39868088
Mammalian nucleophagy: process and function., PMID:39827882
OBI-992, a Novel TROP2-Targeted Antibody-Drug Conjugate, Demonstrates Antitumor Activity in Multiple Cancer Models., PMID:39786401
Phosphine Oxide Indenoquinoline Derivatives: Synthesis and Biological Evaluation as Topoisomerase I Inhibitors and Antiproliferative Agents., PMID:39770084
TOP1 Mutations and Cross-Resistance to Antibody-Drug Conjugates in Patients with Metastatic Breast Cancer., PMID:39745368
TDP1 represents a promising therapeutic target for overcoming tumor resistance to chemotherapeutic agents: progress and potential., PMID:39705934
miR-198 targets TOPORS: implications for oral squamous cell carcinoma pathogenesis., PMID:39697236
PNKP safeguards stalled replication forks from nuclease-dependent degradation during replication stress., PMID:39671289
Not only the top: Type I topoisomerases function in multiple tissues and organs development in plants., PMID:39662729
TDP1 splice-site mutation causes HAP1 cell hypersensitivity to topoisomerase I inhibition., PMID:39660638
Design, synthesis and investigation of biological activity and mechanism of fluoroaryl-substituted derivatives at the FL118 position 7., PMID:39647420
Autophagy as a way to remove DNA lesions., PMID:39635883
The fork protection complex generates DNA topological stress-induced DNA damage while ensuring full and faithful genome duplication., PMID:39589889
TEX264-mediated selective autophagy directs DNA damage repair., PMID:39550277
The cell cycle inhibitor p21CIP1 is essential for irinotecan-induced senescence and plays a decisive role in re-sensitization of temozolomide-resistant glioblastoma cells to irinotecan., PMID:39489121
Epigenetic control of Topoisomerase 1 activity presents a cancer vulnerability., PMID:39484415
Excessive MYC-topoisome activity triggers acute DNA damage, MYC degradation, and replacement by a p53-topoisome., PMID:39481385
Exploring the material basis and molecular targets of Changma Xifeng tablet in treating Tourette syndrome: an integrative approach of network pharmacology and miRNA analysis., PMID:39436634
Crossing the border: Replication fork adducts move to lysosomes for autophagic repair., PMID:39423795
Genome Instability Induced by Topoisomerase Misfunction., PMID:39408578
HNF1β bookmarking involves Topoisomerase 1 activation and DNA topology relaxation in mitotic chromatin., PMID:39388351
Presence of RB1 or Absence of LRP1B Mutation Predicts Poor Overall Survival in Patients with Gastric Neuroendocrine Carcinoma and Mixed Adenoneuroendocrine Carcinoma., PMID:39327909
Glasesterterpenoids A-C: three sesterterpenoids with 7-cyclohexyldecahydronaphthalene carbon skeleton isolated from the root of Lindera glauca., PMID:39326980
Computational screening and molecular docking of compounds from Traditional Chinese Medicine (TCM) by targeting DNA topoisomerase I to design potential anticancer drugs., PMID:39264927
Mechanisms controlling replication fork stalling and collapse at topoisomerase 1 cleavage complexes., PMID:39236719
Identification of 7-aminourea or 7-aminothiourea derivatives of camptothecin as selective topoisomerase I inhibitors with anti-colorectal cancer activities., PMID:39182258
For research use only. Not for human or drug use.
