Catalog No.
YHC87901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser98-Lys313
Predicted molecular weight
27.54 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P11309
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PIM1, Serine/threonine-protein kinase pim-1
Identification of potential human targets for epigallocatechin gallate through a novel protein binding site screening approach., PMID:40512223
Expression of PIM1/ASK1 Molecular Pathway Related Genes in Ischemic Cardiomyopathy., PMID:40511800
Rational Design of Novel Quinazolinone-Pyrrolodihydropyrrolone Analogs as PIM/HDAC Dual-Target Inhibitors for the Treatment of Acute Myelocytic Leukemia., PMID:40444519
Discovery of new pyridine-O-propargyl/1,2,3-triazole hybrids as competitive and non-competitive PIM-1 kinase inhibitors with apoptosis induction and caspase 3/7 activation capabilities., PMID:40383013
PIM kinase control of CD8 T cell protein synthesis and cell trafficking., PMID:40359130
Deciphering the mechanism of baicalein in cervical cancer via bioinformatics, machine learning and computational simulations: PIM1 and CDK2 are key target proteins., PMID:40339869
Valosin-Containing Protein (VCP/p97) Mediates Neuroendocrine Differentiation in Prostate Cancer Cells Through Pim1 Signaling Inducing Autophagy., PMID:40269472
Differential Cellular Responses to Class I and II Sphingomyelinase D: Unraveling the Mechanisms of Loxosceles Venom-Induced Dermonecrosis and Potential Therapeutic Targets., PMID:40243660
UBE4B modulates BET inhibitor sensitivity via KLHL22-JAK2-PIM1 axis in hepatocellular carcinoma., PMID:40228637
Differential response of tissue engineered skeletal muscle from rheumatoid arthritis patients and healthy controls., PMID:40200033
Targeting PIM1 by Bruceine D attenuates skin fibrosis via myofibroblast ferroptosis., PMID:40168881
Pim1 promotes the maintenance of bone homeostasis by regulating osteoclast function., PMID:40164682
[Relapse-related candidate genes and their clinicopathological connections of diffuse large B cell lymphoma]., PMID:40159024
MrgD as a Novel Modeling and Treatment Target for Pulmonary Hypertension., PMID:40143817
Multifunctional Co-Delivery Systems with Downregulation of the Novel Target PIM1 in Macrophages to Ameliorate TF-Mediated Coagulopathy in Sepsis., PMID:40135385
Evaluation of the anti-leukemia activity and underlying mechanisms of the novel perinucleolar compartment inhibitor CTI-2 in acute myeloid leukemia., PMID:40095258
Targeting of PIM Kinases Shows Single Agent Efficacy and Synergizes With BCL2 Inhibitors in Diffuse Large B Cell Lymphoma of the ABC Subtype., PMID:40040616
Using AlphaFold2 to Predict the Conformations of Side Chains in Folded Proteins., PMID:39990457
Inhibition of PIM Kinase in Tumor-Associated Macrophages Suppresses Inflammasome Activation and Sensitizes Prostate Cancer to Immunotherapy., PMID:39982419
Advances in pyrazolo[1,5-a]pyrimidines: synthesis and their role as protein kinase inhibitors in cancer treatment., PMID:39911541
REDD1 is a determinant of the sensitivity of renal cell carcinoma cells to autophagy inhibition that can be therapeutically exploited by targeting PIM activity., PMID:39892703
Discovery of Human PIM Kinase Inhibitors as a Class of Anthelmintic Drugs to Treat Intestinal Nematode Infections., PMID:39828994
Quercetin attenuated ropivacaine-induced neurotoxicity in SH-SY5Y cells through upregulating Pim1 and enhancing autophagy., PMID:39816371
PIM1 enhances insulin secretion and inhibits ferroptosis of high glucose-induced pancreatic β-cells through strengthening PINK1/Parkin-mediated mitophagy via inactivating JNK/p38 signaling pathway., PMID:39813743
Constitutive surface expression of the thromboxane A2 receptor is Pim kinase-dependent., PMID:39798965
CXCR2 Activated JAK3/STAT3 Signaling Pathway Exacerbating Hepatotoxicity Associated with Tacrolimus., PMID:39749191
Zanubrutinib plus R-CHOP for the treatment of newly diagnosed double-expressor lymphoma: A phase 2 clinical study., PMID:39748728
PIM1 instigates endothelial-to-mesenchymal transition to aggravate atherosclerosis., PMID:39744686
RBM19 promotes the progression of prostate cancer under docetaxel treatment via SNHG21/PIM1 axis., PMID:39730751
Upregulation of haematopoetic cell kinase (Hck) activity by a secreted parasite effector protein (Ta9) drives proliferation of Theileria annulata-transformed leukocytes., PMID:39730099
SND1-SMARCA5 interaction strengthened by PIM promotes the proliferation, metastasis, and chemoresistance of esophageal squamous cell carcinoma., PMID:39725102
Integration of bulk/scRNA-seq and multiple machine learning algorithms identifies PIM1 as a biomarker associated with cuproptosis and ferroptosis in abdominal aortic aneurysm., PMID:39723205
FDA-approved drugs as PIM-1 kinase inhibitors: A drug repurposed approach for cancer therapy., PMID:39722389
Harnessing natural compounds for PIM-1 kinase inhibition: A synergistic approach using virtual screening, molecular dynamics simulations, and free energy calculations., PMID:39707767
Visualize PIM-1 Protein Function and Its Interaction With PI3K/Akt/mTOR Pathway Regulated by Its Active Sites Through FRET Biosensors., PMID:39692066
ZIKV prM hijacks PIM1 kinase for phosphorylation to prevent ubiquitin-mediated degradation and facilitate viral replication., PMID:39679197
Efficacy and Safety of Polatuzumab Vedotin Plus Rituximab, Cyclophosphamide, Doxorubicin and Prednisone for Previously Untreated Diffuse Large B-Cell Lymphoma: A Real-World, Multi-Center, Retrospective Cohort Study., PMID:39641321
N-Acetylcysteine Treats Spinal Cord Injury by Inhibiting Astrocyte Proliferation., PMID:39624161
Geometry Optimization Using the Frozen Domain and Partial Dimer Approaches in the Fragment Molecular Orbital Method: Implementation, Benchmark, and Applications to Protein Ligand-Binding Sites., PMID:39621552
Novel Thiazole-Fused [4,5-g] or [5,4-g]Quinazolin-8-ones and Their Quinazoline Analogues: Synthesis and Biological Evaluation., PMID:39598364
Expression and prognostic value of PIM-1 kinase in gliomas., PMID:39569612
Preclinical efficacy of CDK7 inhibitor-based combinations against myeloproliferative neoplasms transformed to AML., PMID:39561280
Effect of hinokitiol in ameliorating oral cancer: in vitro and in silico evidences., PMID:39540968
Design, synthesis, and anti-breast cancer activity evaluation of novel 3-cyanopyridine derivatives as PIM-1 inhibitors., PMID:39521748
Pim1 inactivating induces RUNX3 upregulation that improves/alleviates airway inflammation and mucus hypersecretion in vitro and in vivo., PMID:39521608
Pim1 is Critical in T-cell-independent B-cell Response and MAPK Activation in B Cells., PMID:39505064
Investigating pH-induced conformational switch in PIM-1: An integrated multi spectroscopic and MD simulation study., PMID:39488934
PIM1 kinase and its diverse substrate in solid tumors., PMID:39487435
Synthesis and evaluation of anticancer activity of new 4,5,6,7-tetrabromo-1H-benzimidazole derivatives., PMID:39476601
Molecular docking, DFT and antiproliferative properties of 4-(3,4-dimethoxyphenyl)-3-(4-methoxyphenyl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine as potent anticancer agent with CDK2 and PIM1 inhibition potency., PMID:39467111
For research use only. Not for human or drug use.
