Catalog No.
YHC29501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly28-Thr156
Predicted molecular weight
16.88 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P07998
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Ribonuclease 1, HP-RNase, RNase 1, RNASE1, RNS1, RNase UpI-1, Ribonuclease pancreatic, RNase A, Ribonuclease A, RIB1, RIB-1
RNase1-driven ALK-activation is an oncogenic driver and therapeutic target in non-small cell lung cancer., PMID:40246819
Serum proteomic profiling reveals potential predictive indicators for coronary artery calcification in stable ischemic heart disease., PMID:40106019
Ribonuclease 1 Induces T-Cell Dysfunction and Impairs CD8+ T-Cell Cytotoxicity to Benefit Tumor Growth through Hijacking STAT1., PMID:39932384
Lipid-associated macrophages for osimertinib resistance and leptomeningeal metastases in NSCLC., PMID:39116206
Targeting ALK averts ribonuclease 1-induced immunosuppression and enhances antitumor immunity in hepatocellular carcinoma., PMID:38307859
A comparative urinary proteomic and metabolomic analysis between renal aa amyloidosis and membranous nephropathy with clinicopathologic correlations., PMID:38154551
Identification of the immune-associated characteristics and predictive biomarkers of keratoconus based on single-cell RNA-sequencing and bulk RNA-sequencing., PMID:37965330
Functional interrogation of twenty type 2 diabetes-associated genes using isogenic human embryonic stem cell-derived β-like cells., PMID:37858332
Mass Spectrometric Analysis of Urinary N-Glycosylation Changes in Patients with Parkinson's Disease., PMID:37677068
Unraveling dynamic interactions between tumor-associated macrophages and consensus molecular subtypes in colorectal cancer: An integrative analysis of single-cell and bulk RNA transcriptome., PMID:37662758
Bacterial extracellular vesicles repress the vascular protective factor RNase1 in human lung endothelial cells., PMID:37189117
Integrated analysis of genome-wide gene expression and DNA methylation profiles reveals candidate genes in ovary endometriosis., PMID:37033258
Exploration of prognostic genes and risk signature in breast cancer patients based on RNA binding proteins associated with ferroptosis., PMID:36911389
Transcriptome-wide analysis reveals the coregulation of RNA-binding proteins and alternative splicing genes in the development of atherosclerosis., PMID:36720950
Functions and cellular signaling by ribosomal extracellular RNA (rexRNA): Facts and hypotheses on a non-typical DAMP., PMID:36503009
Structural insights into EphA4 unconventional activation from prediction of the EphA4 and its complex with ribonuclease 1., PMID:36381327
Remote ischemic preconditioning in patients undergoing cardiac surgery with six ischemic cycles., PMID:35849687
Distinct Stress-Dependent Signatures of Cellular and Extracellular tRNA-Derived Small RNAs., PMID:35373532
Sarcopenia and a 5-mRNA risk module as a combined factor to predict prognosis for patients with stomach adenocarcinoma., PMID:34933074
Identification of a three-gene-based prognostic model in multiple myeloma using bioinformatics analysis., PMID:34249481
RNase1 can modulate gut microbiota and metabolome after Aeromonas hydrophila infection in blunt snout bream., PMID:33973327
Ribonuclease1 contributes to the antibacterial response and immune defense in blunt snout bream (Megalobrama amblycephala)., PMID:33454323
New Therapies to Modulate Post-Infarction Inflammatory Alterations in the Myocardium: State of the Art and Forthcoming Applications., PMID:33302861
p38 and Casein Kinase 2 Mediate Ribonuclease 1 Repression in Inflamed Human Endothelial Cells via Promoter Remodeling Through Nucleosome Remodeling and Deacetylase Complex., PMID:33178683
Development and validation of a six-RNA binding proteins prognostic signature and candidate drugs for prostate cancer., PMID:32882325
Prognostic Implications of Novel Gene Signatures in Gastric Cancer Microenvironment., PMID:32740646
Extracellular RNA released due to shear stress controls natural bypass growth by mediating mechanotransduction in mice., PMID:31501155
Phenotype of ribonuclease 1 deficiency in mice., PMID:31053653
Inflammation-mediated deacetylation of the ribonuclease 1 promoter via histone deacetylase 2 in endothelial cells., PMID:31039328
Pattern Recognition Receptors and Control of Innate Immunity: Role of Nucleic Acids., PMID:30636600
RNase1 alleviates the Aeromonas hydrophila-induced oxidative stress in blunt snout bream., PMID:30267738
Self-extracellular RNA acts in synergy with exogenous danger signals to promote inflammation., PMID:29261777
Antitumor Macrophage Response to Bacillus pumilus Ribonuclease (Binase)., PMID:28804220
Host-derived extracellular RNA promotes adhesion of Streptococcus pneumoniae to endothelial and epithelial cells., PMID:27892961
Evolution of Digestive Enzymes and RNASE1 Provides Insights into Dietary Switch of Cetaceans., PMID:27651393
Expression Patterns and Functional Novelty of Ribonuclease 1 in Herbivorous Megalobrama amblycephala., PMID:27213364
Renal systems biology of patients with systemic inflammatory response syndrome., PMID:25993322
Plasminogen activator inhibitor-1 in cigarette smoke exposure and influenza A virus infection-induced lung injury., PMID:25932922
Bovine milk proteome in the first 9 days: protein interactions in maturation of the immune and digestive system of the newborn., PMID:25693162
RNase1 prevents the damaging interplay between extracellular RNA and tumour necrosis factor-α in cardiac ischaemia/reperfusion injury., PMID:25354936
Role of extracellular RNA in atherosclerotic plaque formation in mice., PMID:24201302
Influence of proinflammatory stimuli on the expression of vascular ribonuclease 1 in endothelial cells., PMID:24174426
Regnase-1, a ribonuclease involved in the regulation of immune responses., PMID:24163394
The expansion and functional diversification of the mammalian ribonuclease a superfamily epitomizes the efficiency of multigene families at generating biological novelty., PMID:24162010
Extracellular RNA liberates tumor necrosis factor-α to promote tumor cell trafficking and progression., PMID:23774209
Extracellular nucleic acids as novel alarm signals in the vascular system. Mediators of defence and disease., PMID:23328880
PHF6 regulates cell cycle progression by suppressing ribosomal RNA synthesis., PMID:23229552
Expression and localisation of vascular ribonucleases in endothelial cells., PMID:21103661
Characterization of the angiogenic activity of zebrafish ribonucleases., PMID:19549190
Identification of Apurinic/apyrimidinic endonuclease 1 (APE1) as the endoribonuclease that cleaves c-myc mRNA., PMID:19401441
For research use only. Not for human or drug use.
