Catalog No.
YHC31101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu280-Val405
Predicted molecular weight
16.30 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P08185
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Corticosteroid-binding globulin, Serpin A6, Transcortin, CBG, SERPINA6
Unveiling the levels and significance of different serpin family proteins in aqueous humor dynamics., PMID:40389884
Exploring the genetic influence on hair cortisol concentration: Genetic association of rs11621961 on SERPINA6/1 locus in the 2004 Pelotas Birth Cohort (Brazil)., PMID:40267698
Impaired SERPIN-Protease Balance in the Peripheral Lungs of Stable COPD Patients., PMID:40243422
The NE/AAT/CBG axis regulates adipose tissue glucocorticoid exposure., PMID:39788946
Cortisol, Stress, and Disease-Bidirectional Associations; Role for Corticosteroid-Binding Globulin?, PMID:38941154
Assessing the Role of Cortisol in Anxiety, Major Depression, and Neuroticism: A Mendelian Randomization Study Using SERPINA6/SERPINA1 Variants., PMID:38525495
Identification of BMAL1-Regulated circadian genes in mouse liver and their potential association with hepatocellular carcinoma: Gys2 and Upp2 as promising candidates., PMID:38183795
Position-specific N- and O-glycosylation of the reactive center loop impacts neutrophil elastase-mediated proteolysis of corticosteroid-binding globulin., PMID:38042488
Corticosteroid-Binding Globulin (SERPINA6) Consolidates Sexual Dimorphism of Adult Rat Liver., PMID:38015819
Early Pregnancy Markers in the Serum of Ewes Identified via Proteomic and Metabolomic Analyses., PMID:37762358
Plasma cortisol-linked gene networks in hepatic and adipose tissues implicate corticosteroid-binding globulin in modulating tissue glucocorticoid action and cardiovascular risk., PMID:37745713
Exploratory Study Analyzing the Urinary Peptidome of T2DM Patients Suggests Changes in ECM but Also Inflammatory and Metabolic Pathways Following GLP-1R Agonist Treatment., PMID:37686344
Genomic and Transcriptomic Characterization of Gastric Cancer with Bone Metastasis., PMID:37591783
Exploring molecular dynamic indicators associated with reproductive performance of Bos indicus cattle in blood plasma samples through data-independent acquisition mass spectrometry., PMID:37321300
Rats, Adrenals, and the Surprising Role of the Corticosteroid-Binding Globulin in Sexual Dimorphism., PMID:36402142
Corticosteroid-binding Globulin (SERPINA6) Establishes Postpubertal Sex Differences in Rat Adrenal Development., PMID:36112420
Stress-related genetic components in attention-deficit/hyperactivity disorder (ADHD): Effects of the SERPINA6 and SERPINA1 genetic markers in a family-based brazilian sample., PMID:35217314
Sex-specific maternal programming of corticosteroid-binding globulin by predator odour., PMID:34847769
CBG Montevideo: A Clinically Novel SERPINA6 Mutation Leading to Haploinsufficiency of Corticosteroid-binding Globulin., PMID:34308089
Molecular alterations in oral cancer between tobacco chewers and smokers using serum proteomics., PMID:34024816
Plasma Cortisol and Risk of Atrial Fibrillation: A Mendelian Randomization Study., PMID:33822969
Variation in the SERPINA6/SERPINA1 locus alters morning plasma cortisol, hepatic corticosteroid binding globulin expression, gene expression in peripheral tissues, and risk of cardiovascular disease., PMID:33469137
Identification of Potential Serum Protein Biomarkers and Pathways for Pancreatic Cancer Cachexia Using an Aptamer-Based Discovery Platform., PMID:33334063
Pyrexia and acidosis act independently of neutrophil elastase reactive center loop cleavage to effect cortisol release from corticosteroid-binding globulin., PMID:33085168
Circulating proteomic panels for diagnosis and risk stratification of acute-on-chronic liver failure in patients with viral hepatitis B., PMID:30867825
Stress-related genetic polymorphisms in association with peripartum depression symptoms and stress hormones: A longitudinal population-based study., PMID:30776573
Corticosteroid-binding globulin: acute and chronic inflammation., PMID:30058887
High-throughput profiling of the circulating proteome suggests sexually dimorphic corticosteroid signaling following ischemic stroke., PMID:30029587
Polygenic risk score of SERPINA6/SERPINA1 associates with diurnal and stress-induced HPA axis activity in children., PMID:29679879
Leydig cell genes change their expression and association with polysomes in a stage-specific manner in the adult mouse testis., PMID:29408990
The EndoC-βH1 cell line is a valid model of human beta cells and applicable for screenings to identify novel drug target candidates., PMID:29307512
The role of corticosteroid-binding globulin in the evaluation of adrenal insufficiency., PMID:29194043
Genomic determinants of long-term cardiometabolic complications in childhood acute lymphoblastic leukemia survivors., PMID:29126409
Endocrine disruption: In silico interactions between phthalate plasticizers and corticosteroid binding globulin., PMID:28677244
Relative Adrenal Insufficiency is Associated with the Clinical Outcome in Patients with Stable Decompensated Cirrhosis., PMID:28611262
Monoclonal antibodies to the reactive centre loop (RCL) of human corticosteroid-binding globulin (CBG) can protect against proteolytic cleavage., PMID:28411181
Total and free cortisol responses and their relation to outcomes after cardiopulmonary bypass in infants., PMID:28024808
A naturally hypersensitive glucocorticoid receptor elicits a compensatory reduction of hypothalamus-pituitary-adrenal axis activity early in ontogeny., PMID:27440422
Asn347 Glycosylation of Corticosteroid-binding Globulin Fine-tunes the Host Immune Response by Modulating Proteolysis by Pseudomonas aeruginosa and Neutrophil Elastase., PMID:27339896
Reduced corticosteroid-binding globulin cleavage in active rheumatoid arthritis., PMID:27061835
Identification of Avian Corticosteroid-binding Globulin (SerpinA6) Reveals the Molecular Basis of Evolutionary Adaptations in SerpinA6 Structure and Function as a Steroid-binding Protein., PMID:27026706
Gq/11-Dependent Changes in the Murine Ovarian Transcriptome at the End of Gestation., PMID:26843449
Corticosteroid-binding globulin (CBG) reactive centre loop antibodies and surface plasmon resonance interrogate the proposed heat dependent "flip-flop" mechanism of human CBG., PMID:26829559
New Roles for Corticosteroid Binding Globulin and Opposite Expression Profiles in Lung and Liver., PMID:26741814
Colony-Specific Differences in Endocrine and Immune Responses to an Inflammatory Challenge in Female Sprague Dawley Rats., PMID:26402842
Analysis of non-synonymous SNPs of the porcine SERPINA6 gene as potential causal variants for a QTL affecting plasma cortisol levels on SSC7., PMID:25754835
Somatostatin is essential for the sexual dimorphism of GH secretion, corticosteroid-binding globulin production, and corticosterone levels in mice., PMID:25551181
Naturally occurring mutations of human corticosteroid-binding globulin., PMID:25322275
Integrative genomic analysis identifies that SERPINA6-rs1998056 regulated by FOXA/ERα is associated with female hepatocellular carcinoma., PMID:25198130
Genome wide association identifies common variants at the SERPINA6/SERPINA1 locus influencing plasma cortisol and corticosteroid binding globulin., PMID:25010111
For research use only. Not for human or drug use.
