Catalog No.
YHC32901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu85-Ser337
Predicted molecular weight
30.09 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P08397
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Hydroxymethylbilane synthase, PBG-D, Pre-uroporphyrinogen synthase, Porphobilinogen deaminase, PBGD, UPS, HMBS
Physiological Benefits, Applications, and Future Directions of β-Hydroxy-β-Methylbutyrate (HMB) in Food and Health Industries., PMID:40282696
Beta-hydroxy-beta-methylbutyrate (HMB) ameliorates DSS-induced colitis by inhibiting ERK/NF-κB activation in macrophages., PMID:39978274
A novel acquired resistance mechanism to 5-aminolevulinic acid-mediated photodynamic therapy with ABCG2 inhibition., PMID:39900503
International society of sports nutrition position stand: β-hydroxy-β-methylbutyrate (HMB)., PMID:39699070
FiTMuSiC: leveraging structural and (co)evolutionary data for protein fitness prediction., PMID:38627807
Selection of suitable reference genes for normalization of RT-qPCR in three tissues of Northern bobwhite (Colinus virginianus) infected with eyeworm (Oxyspirura petrowi)., PMID:38578540
Neurodevelopmental disorder in a patient with HMBS and SCN3A variants-A possibly blended phenotype further delineating autosomal recessive HMBS related disease., PMID:38568055
Identification and validation of extracellular vesicle reference genes for the normalization of RT-qPCR data., PMID:38545822
A diagnostic model based on bioinformatics and machine learning to differentiate bipolar disorder from schizophrenia and major depressive disorder., PMID:38355593
Functional and structural analysis of a novel splice site HMBS variant in a Chinese AIP patient., PMID:38192441
Identification of common genes and pathways underlying imatinib and nilotinib treatment in CML: a Bioinformatics Study., PMID:38117080
Cross-sectional associations between 24-hour movement behaviors and cardiometabolic health among adults with type 2 diabetes mellitus: A comparison according to weight status., PMID:38114412
Screening and Identifying Reference Genes for Erythrocyte Production from Cord Blood CD34+ Cells Exposed to Hypoxia., PMID:38011643
Genetic analysis of acute intermittent porphyria caused by novel classical splicing variant in the insertion region of 29-residue specific to human HMBS protein., PMID:37635937
YWHAZ and TBP are potential reference gene candidates for qPCR analysis of response to radiation therapy in colorectal cancer., PMID:37558778
A role of splenic heme biosynthesis pathway in the persistent prophylactic actions of arketamine in lipopolysaccharide-treated mice., PMID:37491335
Muscle-building supplement β-hydroxy β-methylbutyrate binds to PPARα to improve hippocampal functions in mice., PMID:37437568
Identification of stable reference genes for quantitative gene expression analysis in the duodenum of meat-type ducks., PMID:37077952
[Variation in the level of the biocomponents immunoglobulin A and lactoferrin in human milk after Holder pasteurization]., PMID:36748426
AGA Clinical Practice Update on Diagnosis and Management of Acute Hepatic Porphyrias: Expert Review., PMID:36642627
A comprehensive landscape of transcription profiles and data resources for human leukemia., PMID:36595475
Gene-Level Associations in Patients With and Without Pathogenic Germline Variants in CDKN2A and Pancreatic Cancer., PMID:36409970
Sensory characterization of yellow pea and ground chicken hybrid meat burgers using static and dynamic methodologies., PMID:36302120
Heterogeneous molecular behavior in liver tumors (HCC and CCA) of two patients with acute intermittent porphyria., PMID:36245063
Identifying stable reference genes in polyethene glycol precipitated urinary extracellular vesicles for RT-qPCR-based gene expression studies in renal graft dysfunction patients., PMID:36122652
Whole-exome sequencing reveals a comprehensive germline mutation landscape and identifies twelve novel predisposition genes in Chinese prostate cancer patients., PMID:36095024
Bi-allelic hydroxymethylbilane synthase inactivation defines a homogenous clinico-molecular subtype of hepatocellular carcinoma., PMID:35636578
Analysis of corticosteroid and antiepileptic drug treatment effects on heme biosynthesis mRNA expression in lower-grade gliomas: Potential implications for 5-ALA metabolization., PMID:35149260
Antiangiogenic Nanomicelles for the Topical Delivery of Aflibercept to Treat Retinal Neovascular Disease., PMID:34726299
Two Novel Hydroxymethylbilane Synthase Splicing Mutations Predispose to Acute Intermittent Porphyria., PMID:34681668
Plasmodium falciparum hydroxymethylbilane synthase does not house any cosynthase activity within the haem biosynthetic pathway., PMID:34661520
Reference gene screening for analyzing gene expression in the heart, liver, spleen, lung and kidney of forest musk deer., PMID:34615843
Systematic analysis of candidate reference genes for gene expression analysis in hyperoxia-based mouse models of bronchopulmonary dysplasia., PMID:34378408
Do Maternal Factors and Milk Expression Patterns Affect the Composition of Donor Human Milk?, PMID:34371935
Evaluation of Reliable Reference Genes for In Vitro Erythrocyte Generation from Cord Blood CD34+ Cells., PMID:34227876
Screening of Reference Genes for RT-qPCR in Chicken Adipose Tissue and Adipocytes., PMID:34054585
Identification of reliable reference genes for expression studies in the magnum of laying hens housed in cage and cage-free systems., PMID:34015187
Stability of housekeeping genes in inflamed joints of spontaneous and collagen-induced arthritis in DBA/1 mice., PMID:33903928
Crystal structures of hydroxymethylbilane synthase complexed with a substrate analog: a single substrate-binding site for four consecutive condensation steps., PMID:33600566
Acute Intermittent Porphyria: An Overview of Therapy Developments and Future Perspectives Focusing on Stabilisation of HMBS and Proteostasis Regulators., PMID:33445488
No evidence for sylvatic cycles of chikungunya, dengue and Zika viruses in African green monkeys (Chlorocebus aethiops sabaeus) on St. Kitts, West Indies., PMID:33126907
Selection of endogenous control genes for normalising gene expression data derived from formalin-fixed paraffin-embedded tumour tissue., PMID:33057113
TCGA mRNA Expression Analysis of the Heme Biosynthesis Pathway in Diffusely Infiltrating Gliomas: A Comparison of Typically 5-ALA Fluorescent and Non-Fluorescent Gliomas., PMID:32722247
Network analysis of hydroxymethylbilane synthase dynamics., PMID:32619952
A mysterious case with abdominal pain and syndrome of inappropriate anti-diuretic hormone secretion., PMID:32558425
Epigallocatechin Gallate Enhances MAL-PDT Cytotoxic Effect on PDT-Resistant Skin Cancer Squamous Cells., PMID:32397263
A novel heterozygous mutation in the HMBS gene in a patient with acute intermittent porphyria and posterior reversible encephalopathy syndrome., PMID:32377710
Validation of Suitable Reference Genes for Gene Expression Studies on Yak Testis Development., PMID:31973196
Differential regulation of mTORC1 activation by leucine and β-hydroxy-β-methylbutyrate in skeletal muscle of neonatal pigs., PMID:31944890
For research use only. Not for human or drug use.
