Catalog No.
YHC30601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Phe2-Glu234
Predicted molecular weight
27.03 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P08151
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Oncogene GLI, GLI, Glioma-associated oncogene, GLI1, Zinc finger protein GLI1
SIRT5 regulates granulosa cell proliferation and apoptosis in polycystic ovarian syndrome via desuccinylation of GLI1., PMID:40481676
RAC1 Regulates Shh-Medulloblastoma Growth via GLI-Mediated Transcription., PMID:40475618
MSC-Derived Exosomal MiR-127-3p Alleviates Acute Kidney Ischemia-Reperfusion Injury via Suppressing ATG5/ATG7-Mediated Autophagy., PMID:40452255
Wnt/β-catenin regulates Gli1 + osteogenic progenitors in condylar subchondral bone development and osteoarthritis., PMID:40448062
Targeting YAP-Hhip-mediated osteogenesis in Gli1+ osteogenic progenitors suppresses aberrant subchondral bone remodeling in osteoarthritis., PMID:40447254
β,β-Dimethylacryloyl Alkannin from Arnebia euchroma Roots Suppresses Triple-Negative Breast Cancer Growth via AKT/Gli1 Signaling., PMID:40393938
Hyaluronan-decorated-phloroglucinol-loaded mesoporous silica nanoparticles downregulate GLI1 and SMO genes of hedgehog signaling pathway in gastrointestinal cancer stem-like cells., PMID:40393597
VRK1/BANF1/GLI1 Axis Regulates Tumor Development and Progression of Colorectal Cancer., PMID:40384864
Acquired resistance to vemurafenib restrains thyroid cancer stem cell self-renewal by suppressing STAT3 activation., PMID:40345509
Xingxiao pills suppresses lung adenocarcinoma progression by modulating lipid metabolism and inhibiting the PLA2G4A-GLI1-SOX2 Axis., PMID:40339555
Crosstalk Between Wnt/β-Catenin and Hedgehog Supports Gli1+ Lineage Osteogenesis in Cranial Sutures., PMID:40332045
Modulating Cancer Stem Cell Characteristics in CD133+ Melanoma Cells through Hif1α, KLF4, and SHH Silencing., PMID:40321496
Embryonic exposure to Smoothened Agonist disrupts tongue development in mice., PMID:40311729
[Primary kidney GLI1-altered mesenchymal tumor: report of a case]., PMID:40302585
Alpha-estradiol and (R)-(-)-ibuprofen inhibit gastric cancer progression via GLI1 G-quadruplex., PMID:40255562
ADAR1-high tumor-associated macrophages induce drug resistance and are therapeutic targets in colorectal cancer., PMID:40241135
Hedgehog pathway inhibitor HhAntag suppresses virus infection via the GLI-S1PR axis., PMID:40239727
"Putting the cart before the horse": an update on promiscuous gene fusions in soft tissue tumors., PMID:40205020
COPD susceptibility gene HHIP regulates repair genes in airway epithelial cells and repair within the epithelial-mesenchymal trophic unit., PMID:40192657
Multiparametric MRI Can Detect Enhanced Myelination in the Ex Vivo Gli1-/- Mouse Brain., PMID:40174963
Increased expression of PTCH1 and GLI1 in Bangladeshi TNBC Patients after Treatment with Doxorubicin and Cyclophosphamide Suggests a Favorable Response to Chemotherapy., PMID:40156412
O-GlcNAcylation in Gli1+ Mesenchymal Stem Cells Is Indispensable for Bone Formation and Fracture Healing., PMID:40141354
Depleting Yes-Associated Protein in Gli1-Expressing Cells Attenuates Peritoneal Dialysis-Induced Peritoneal Fibrosis., PMID:40133213
USP22/BRD4 mediated hedgehog pathway activation contributes to airway remodeling in asthma., PMID:40132456
Novel C-2 Aromatic Heterocycle-Substituted Triterpenoids Inhibit Hedgehog Signaling in GLI1 Overexpression Cancer Cells., PMID:40124057
Hypoxia-inducible factor-1 alpha (HIF-1α) inhibitor AMSP-30 m attenuates CCl4-induced liver fibrosis in mice by inhibiting the sonic hedgehog pathway., PMID:40113123
Pentose phosphate recycling driven by Gli1 contributes to chemotherapy resistance in cancer cells., PMID:40090571
Sonic Hedgehog potentiates BMP9-induced osteogenic differentiation of mesenchymal stem cells., PMID:40070367
Racial Diversity and Co-Mutational Analysis of Biologically Relevant Alterations in EGFR Mutant Lung Cancers., PMID:40064574
NaHS@Cy5@MS@SP nanoparticles improve rheumatoid arthritis by inactivating the Hedgehog signaling pathway through sustained and targeted release of H2S into the synovium., PMID:40055697
Inflammation-triggered Gli1+ stem cells engage with extracellular vesicles to prime aberrant neutrophils to exacerbate periodontal immunopathology., PMID:40016585
An epitranscriptomic program maintains skeletal stem cell quiescence via a METTL3-FEM1B-GLI1 axis., PMID:40016417
The MEK5/ERK5 pathway promotes the activation of the Hedgehog/GLI signaling in melanoma cells., PMID:39998753
GABP Promotes Mesangial Cell Proliferation and Renal Fibrosis Through GLI1 in Diabetic Nephropathy., PMID:39985381
SMARCB1-driven EGFR-GLI1 epigenetic alterations in lung cancer progression and therapy are differentially modulated by MEOX2 and GLI-1., PMID:39971779
Cooperative Hedgehog/GLI and JAK/STAT signaling drives immunosuppressive tryptophan/kynurenine metabolism via synergistic induction of IDO1 in skin cancer., PMID:39962447
FSP1/S100A4-Expressing Stem/Progenitor Cells Are Essential for Temporomandibular Joint Growth and Homeostasis., PMID:39953712
[Gastric tumors with GLI1 gene alterations (plexiform fibromyxoma and gastroblastoma). Case report and literature review]., PMID:39943727
The Hedgehog-GLI1 Pathway Regulates Osteogenic Differentiation of Human Cervical Posterior Longitudinal Ligament Cells by BMP Signalling Pathway., PMID:39910703
USP39 phase separates into the nucleolus and drives lung adenocarcinoma progression by promoting GLI1 expression., PMID:39885503
PDE4 inhibitor rolipram represses hedgehog signaling via ubiquitin-mediated proteolysis of GLI transcription factors to regress breast cancer., PMID:39880092
Type 3 deiodinase activation mediated by the Shh/Gli1 axis promotes sepsis-induced metabolic dysregulation in skeletal muscles., PMID:39877839
Enhancer-driven Shh signaling promotes glia-to-mesenchyme transition during bone repair., PMID:39865079
GLI1-Rearranged Enteric Tumors: Updates on Clinicopathologic and Molecular Genetics Features., PMID:39851545
miR-301a-mediated crosstalk between the Hedgehog and HIPPO/YAP signaling pathways promotes pancreatic cancer., PMID:39846248
Oncogenic potential of truncated-Gli3 via the Gsk3β/Gli3/AR-V7 axis in castration-resistant prostate cancer., PMID:39821099
In Utero Perfluorodecanoic Acid Exposure Causes Fetal Leydig Cell Dysfunction via Endoplasmic Reticulum Stress-Mediated Lipid Composition Alteration., PMID:39814558
NAB2::STAT6 Rearranged Carcinoma of the Parotid Gland with Sebaceous Differentiation: A Case Report., PMID:39804544
Counterregulatory roles of GLI2 and GLI3 in osteogenic differentiation via Gli1 expression., PMID:39801296
The Role of Gli1+ Mesenchymal Stem Cells in Craniofacial Development and Disease Treatment., PMID:39794930
For research use only. Not for human or drug use.
