Catalog No.
YHE92201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Phe46-Pro306
Predicted molecular weight
31.76 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P52564
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
MEK6, Dual specificity mitogen-activated protein kinase kinase 6, SAPKK-3, PRKMK6, MAPK/ERK kinase 6, Stress-activated protein kinase kinase 3, MAP2K6, SKK3, MKK6, MAPKK 6, SAPKK3, MEK 6, MAP kinase kinase 6, SAPK kinase 3
The discrepancies in amino acid sequence of the phosphate-binding loop lead to distinctive binding modes of a covalent inhibitor for MAP2K1 and MAP2K6: Structural insights for producing selective inhibitors., PMID:40378928
Artificial intelligence-assisted RNA-binding protein signature for prognostic stratification and therapeutic guidance in breast cancer., PMID:40308601
Nuclear translocation of CDK5RAP3 regulated by NXF3 promotes the progression of gastric cancer., PMID:40032765
WTAP-Mediated N6-Methyladenosine Modification Promotes Gastric Cancer Progression by Regulating MAP2K6 Expression., PMID:39991580
Knocking out p38α+p38β+p38γ is required to abort the myogenic program in C2C12 myoblasts and to impose uncontrolled proliferation., PMID:39922491
Map2k6 is a potent genetic modifier of arterial rupture in vascular Ehlers-Danlos syndrome mice., PMID:39836470
Identification of a novel immune checkpoint-related gene signature predicts prognosis and immunotherapy in breast cancer and experiment verification., PMID:39730892
A combined transcriptomics and proteomics approach reveals S100A4 as a potential biomarker for Graves' orbitopathy., PMID:39359477
The endogenous association among MMP2/miR-1248/Circ_0087558/miR-643/ MAP2K6 axis can contribute to brain metastasis in basal-like subtype of breast cancer., PMID:39027611
Physiological and transcriptomic analysis provides new insights into osmoregulation mechanism of Ruditapes philippinarum under low and high salinity stress., PMID:38750748
Identification of Breast Cancer Subtypes Based on Endoplasmic Reticulum Stress-Related Genes and Analysis of Prognosis and Immune Microenvironment in Breast Cancer Patients., PMID:38725284
Integrative ATAC-seq and RNA-seq analysis of myogenic differentiation of ovine skeletal muscle satellite cell., PMID:38692440
The involvement of RIPK4 in TNF-α-stimulated IL-6 and IL-8 production by melanoma cells., PMID:38656555
Lapatinib combined with doxorubicin causes dose-dependent cardiotoxicity partially through activating the p38MAPK signaling pathway in zebrafish embryos., PMID:38653111
A novel PD-1/PD-L1 pathway-related seven-gene signature for the development and validation of the prognosis prediction model for breast cancer., PMID:38617520
Modeling Molecular Mechanisms of Pirfenidone Interaction with Kinases., PMID:38585747
MiR-290 Family Maintains Pluripotency and Self-Renewal by Regulating MAPK Signaling Pathway in Intermediate Pluripotent Stem Cells., PMID:38473927
[Research of miR-29a on TGF-β1/Smad3 pathway in pulmonary fibrosis induced by neodymium oxide]., PMID:38311943
Sanshimao formula inhibits the hypoxia-induced pro-angiogenesis of hepatocellular carcinoma cells partly through regulating MKK6/p38 signaling pathway., PMID:38290061
Identification of circulating autoantibodies to non-modified proteins associated with ACPA status in early rheumatoid arthritis., PMID:38195995
LncRNA PTTG3P promotes tumorigenesis and metastasis of NSCLC by binding with ILF3 to maintain mRNA stability and form a positive feedback loop with E2F1., PMID:37705754
Detection of the effect of microvibrational stimulation on human discarded immature oocytes by single-cell transcriptome sequencing technology., PMID:37273164
Pin-Pointing the Key Hubs in the IFN-γ Pathway Responding to SARS-CoV-2 Infection., PMID:36298734
APEX1 promotes the oncogenicity of hepatocellular carcinoma via regulation of MAP2K6., PMID:36205565
Beyond targeting amplified MDM2 and CDK4 in well differentiated and dedifferentiated liposarcomas: From promise and clinical applications towards identification of progression drivers., PMID:36119484
Identification of ceRNA regulatory network in acute pancreatitis and acute recurrent pancreatitis., PMID:36052691
MKK6 deficiency promotes cardiac dysfunction through MKK3-p38γ/δ-mTOR hyperactivation., PMID:35971771
Long noncoding RNA MAGI2-AS3 regulates the H2O2 level and cell senescence via HSPA8., PMID:35797800
Circ_0005925 Promotes Granulosa Cell Growth by Targeting MiR-324-3p to Upregulate MAP2K6 in Polycystic Ovary Syndrome., PMID:35689709
Gamma synuclein promotes cancer metastasis through the MKK3/6-p38MAPK cascade., PMID:35637967
Protective Signature of IFNγ-Stimulated Microglia Relies on miR-124-3p Regulation From the Secretome Released by Mutant APP Swedish Neuronal Cells., PMID:35620289
Fenbendazole and its synthetic analog interfere with HeLa cells' proliferation and energy metabolism via inducing oxidative stress and modulating MEK3/6-p38-MAPK pathway., PMID:35569513
Identification of a combined apoptosis and hypoxia gene signature for predicting prognosis and immune infiltration in breast cancer., PMID:35441810
Inhibition of IL17A Using an Affibody Molecule Attenuates Inflammation in ApoE-Deficient Mice., PMID:35282365
Selenium nanoparticles alleviate lead acetate-induced toxicological and morphological changes in rat testes through modulation of calmodulin-related genes expression., PMID:35194871
MiR-1298-5p level downregulation induced by Helicobacter pylori infection inhibits autophagy and promotes gastric cancer development by targeting MAP2K6., PMID:35192930
Exome sequencing reveals the first intragenic deletion in ABCA5 underlying autosomal recessive hypertrichosis., PMID:35150007
MEK6 Overexpression Exacerbates Fat Accumulation and Inflammatory Cytokines in High-Fat Diet-Induced Obesity., PMID:34948353
MAP2K6 remodels chromatin and facilitates reprogramming by activating Gatad2b-phosphorylation dependent heterochromatin loosening., PMID:34815549
A novel tumour suppressor protein encoded by circMAPK14 inhibits progression and metastasis of colorectal cancer by competitively binding to MKK6., PMID:34709743
CircRNA-MSR Regulates LPS-Induced C28/I2 Chondrocyte Injury through miR-643/MAP2K6 Signaling Pathway., PMID:34581623
Effect of Rho-Associated Kinase Inhibitor and Mesenchymal Stem Cell-Derived Conditioned Medium on Corneal Endothelial Cell Senescence and Proliferation., PMID:34207965
Beiging Modulates Inflammatory Adipogenesis in Salt-Treated and MEK6-Transfected Adipocytes., PMID:34064531
In silico comparative analysis of LRRK2 interactomes from brain, kidney and lung., PMID:33915162
The interaction of p38 with its upstream kinase MKK6., PMID:33554397
Genetic regulation of liver lipids in a mouse model of insulin resistance and hepatic steatosis., PMID:33417276
CircASPH promotes KGN cells proliferation through miR-375/MAP2K6 axis in Polycystic Ovary Syndrome., PMID:33372369
Elevated miR-10a-5p facilitates cell cycle and restrains adipogenic differentiation via targeting Map2k6 and Fasn, respectively., PMID:33128541
Quercetin inhibits caerulein-induced acute pancreatitis through regulating miR-216b by targeting MAP2K6 and NEAT1., PMID:33051781
Spliced genes in muscle from Nelore Cattle and their association with carcass and meat quality., PMID:32895448
For research use only. Not for human or drug use.
