Catalog No.
YHE16901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asn112-Lys377
Predicted molecular weight
31.80 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P36222
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CHI3L1, GP-39, YKL-40, Chitinase-3-like protein 1, CGP-39, 39 kDa synovial protein, hCGP-39, Cartilage glycoprotein 39
Identification of protein biomarker candidates associated with organ-specific immune-related toxicity and response to management by plasma proteomics., PMID:40510441
Kasugamycin inhibits melanoma lung metastasis and regulates CHI3L1-driven M2-like tumor-associated macrophage differentiation., PMID:40501604
Fh15 Reduces Colonic Inflammation and Leukocyte Infiltration in a Dextran Sulfate Sodium-Induced Ulcerative Colitis Mouse Model., PMID:40497975
Chitinase-3-Like 1 Protein (CHI3L1) Levels in Patients With Cognitive Deficits and Movement Disorders: Comparison With Other Biomarkers., PMID:40495463
Clinical utility of YKL-40 for understanding pathophysiology of obstructive airway disorders., PMID:40483222
Decoding disease burden in multiple sclerosis: The role of IL-10 as biomarker of neuroinflammation and neurodegeneration., PMID:40472791
Increased serum YKL-40 levels in children with sickle cell disease., PMID:40466684
CHI3L1-Targeted Small Molecules as Glioblastoma Therapies: Virtual Screening-Based Discovery, Biophysical Validation, Pharmacokinetic Profiling, and Evaluation in Glioblastoma Spheroids., PMID:40462910
[Advances in pathogenesis of asthma airway remodeling and intervention mechanism of traditional Chinese medicine]., PMID:40461218
Cerebrospinal Fluid Biomarkers in Opioid Dependence: Evidence of Neuroimmune Activation and Ion Composition Changes, Without Alteration in Orexin-A., PMID:40454659
Identification of potential diagnostic markers and molecular mechanisms of asthma and ulcerative colitis based on bioinformatics and machine learning., PMID:40443529
Macrophage activation determines muscle wasting in pancreatic cancer., PMID:40442475
Comparison of middle molecule removal with expanded hemodialysis versus haemodiafiltration among Chinese hemodialysis patients., PMID:40441692
The relationship between multiple plasma biomarker levels and renal disease activity in Fabry disease., PMID:40420032
Unveiling the hidden dance: SPP1 + macrophages identified in ulcerative colitis reveal crosstalk with CHI3L1 + fibroblasts., PMID:40399882
The emerging role of chitinase-3-like-1 protein in neurodegeneration., PMID:40397263
Relationships between neuropsychiatric symptoms, subtypes of astrocyte activities, and brain pathologies in Alzheimer's disease and Parkinson's disease., PMID:40390204
Changes in serum levels of Chitinase protein-40 in children with Kawasaki disease and its clinical significance., PMID:40380159
Plasma CHI3L1 associates with brain volume loss and glial activation in multiple sclerosis., PMID:40379482
Anti-CHI3L1 antibody suppresses colon cancer growth through downregulation of VEGFA and NAMPT expression., PMID:40377878
Implications of Chitinase 3-like 1 Protein in the Pathogenesis of Multiple Sclerosis in Autopsied Brains and a Murine Model., PMID:40362399
Development of a chitosanase 3-like protein 1 assay kit and study of its application in patients with hepatocellular carcinoma., PMID:40355912
Chitinase 3-like protein 1: a diagnostic biomarker for early liver fibrosis in autoimmune liver diseases., PMID:40352927
Cerebrospinal fluid YKL-40 relates to white matter hyperintensity progression in females but not males over a 6-year period., PMID:40352684
Anti-arthritis Effect of Anti-chitinase-3-like 1 Antibody Through Inhibition of MMP3., PMID:40342842
Dieckol ameliorates inflammatory response via inhibition of CHI3L1 expression in collagen-induced arthritis rats., PMID:40342118
Human chitinases and chitinase-like proteins as emerging drug targets - a medicinal chemistry perspective., PMID:40313579
Immunological Fluid Biomarkers in Frontotemporal Dementia: A Systematic Review., PMID:40305176
Identification of plasma biomarkers for non-invasive diagnosis of hepatitis B cirrhosis., PMID:40300315
High Glucose-induced transcriptomic changes in human trabecular meshwork cells., PMID:40278947
Pretreatment plasma sCD14 as a prognostic indicator in advanced non-small cell lung cancer patients undergoing immunotherapy., PMID:40269765
Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles., PMID:40269509
Abnormally high expression of CHI3L1 in peripheral blood mononuclear cells and serum and their potential diagnosis and prediction from lymphoma patients., PMID:40260255
Therapeutic potential of CHI3L1 in osteoarthritis: Inhibition of cartilage matrix degradation and inflammation through TLR4-MAPK-STAT1 pathway., PMID:40253766
Identification of unique biomarkers for proliferative diabetic retinopathy with tractional retinal detachment by proteomics profiling of vitreous humor., PMID:40251337
Thyroid function and hepatic fibrosis/cirrhosis: a two-sample Mendelian randomization study., PMID:40242471
Mechanistic studies on the role of CHI3L1 in eosinophilic inflammation in chronic sinusitis., PMID:40201175
Chitinase 3-like protein 1 deficiency ameliorates drug-induced acute liver injury by inhibition of neutrophil recruitment through lipocalin-2., PMID:40196357
Unveiling mechanisms underlying kidney function changes during sex hormone therapy., PMID:40193283
YKL-40 and risk of incident cancer in early type 2 diabetes: a Danish cohort study., PMID:40188292
Inhibition of CHI3L1 attenuates excessive autophagy in intestinal epithelial cells to reduce the severity of necrotizing enterocolitis., PMID:40188090
Respiratory symptoms, sensitisation and occupational exposure in the shrimp processing industry., PMID:40181810
Neurodegenerative and neuroinflammatory changes in SOD1-ALS patients receiving tofersen., PMID:40169784
PRDX-4: a novel biomarker similar to KL-6 for predicting the occurrence and progression of systemic sclerosis-ILD., PMID:40169424
Plasma biomarker trajectories: Impact of AD genetic risk and clinical progression., PMID:40151521
Systematic review of differentially abundant proteins in people with Lewy body dementia., PMID:40143552
Alternative splicing of CHI3L1 regulates protein secretion through conformational changes., PMID:40126865
Fibrosis-Related Gene and Protein Expression in Normal and Glaucomatous Trabecular Meshwork Cells., PMID:40126508
CHI3L1 mediates radiation resistance in colorectal cancer by inhibiting ferroptosis via the p53/SLC7A11 pathway., PMID:40119400
An analysis of the clinical value of CHI3L1 as a biomarker of multiple myeloma progression., PMID:40118129
For research use only. Not for human or drug use.
