Catalog No.
YHE12801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp311-Pro559
Predicted molecular weight
29.90 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P35558
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PCK1, PEPCK1, PEPCK-C, Serine-protein kinase PCK1, Phosphoenolpyruvate carboxykinase, cytosolic [GTP]
A Study on the Differences in Rumen Microbiota-Liver Gluconeogenesis-Mitochondrial Interaction Between Tibetan Sheep and Hu Sheep in the Qinghai-Tibet Plateau., PMID:40509071
Analyzing the potential targets and mechanism of per- and polyfluoroalkyl substances (PFAS) on breast cancer by integrating network toxicology, single-cell sequencing, spatial transcriptomics, and molecular simulation., PMID:40465018
Decreased expression of insulin-degrading enzyme increases gluconeogenesis and glucose production in cultured hepatocytes administered with glucagon., PMID:40450129
TRPC6-targeted dexamethasone nanobubbles with ultrasound-guided theranostics for adriamycin-induced nephropathy., PMID:40448086
Protective effect of phosphoenolpyruvate carboxykinase 1 on inflammation and fibrotic progression of IgA nephropathy., PMID:40442892
Identification and Functional Analysis of a Key Gene in the CHH Gene Family for Glucose Metabolism in the Pacific White Shrimp Litopenaeus vannamei., PMID:40429756
Integrating machine learning and molecular docking to decipher the molecular network of aflatoxin b1-induced hepatocellular carcinoma., PMID:40392001
Covalent binding of thioredoxin to TXNIP is required for diet-induced insulin resistance in the liver., PMID:40345590
Inhibitory role of arecaidine on PPARγ signaling in oral mucosa: Mechanistic insights from transcriptome and experimental analysis., PMID:40339757
Transcriptomic and epigenomic signatures of liver metabolism and insulin sensitivity in aging mice., PMID:40324540
Identification of Key Genes Related to Intramuscular Fat Content of Psoas Major Muscle in Saba Pigs by Integrating Bioinformatics and Machine Learning Based on Transcriptome Data., PMID:40282015
Hepatic gluconeogenesis and PDK3 upregulation drive cancer cachexia in flies and mice., PMID:40275022
Transcriptomic analysis reveals "adipogenesis" in the uterosacral ligaments of postmenopausal women with recurrent pelvic organ prolapse., PMID:40177764
Discovery of the 2,3-Dihydrobenzopyrane-4-one as a Potent FTO Inhibitor against Obesity-Related Metabolic Diseases., PMID:40152179
Huangqi and Danshen improve the chronic nephrotoxicity of cyclosporin A by regulating lipid metabolism., PMID:40056636
PCK1 inhibits cGAS-STING activation by consumption of GTP to promote tumor immune evasion., PMID:40048154
RNA-seq analysis reveals transcriptome changes in livers from Efcab4b knockout mice., PMID:40034259
Glucose and Insulin Differently Regulate Gluconeogenic and Ureagenic Gene Expression., PMID:40024748
Comprehensive analysis of lncRNA and mRNA expression in triploid rainbow trout (Oncorhynchus mykiss) liver in response to chronic hypoxia., PMID:39985983
The neglected PCK1/glucagon (inter)action in nutrient homeostasis beyond gluconeogenesis: Disease pathogenesis and treatment., PMID:39954782
PCK1 and SLC22A2 gene variants associated with response to metformin treatment in type 2 diabetes., PMID:39928707
Metformin inhibits the histone methyltransferase CARM1 and attenuates H3 histone methylation during gluconeogenesis., PMID:39922487
Metabolic effects of heterocyclic amines on insulin‑induced AKT phosphorylation and gluconeogenic gene expression are modified by N -acetyltransferase 2 genetic polymorphism., PMID:39878101
Suppression of PCK1 attenuates neuronal injury and improves post-resuscitation outcomes., PMID:39826848
FAM136A depletion induces mitochondrial stress and reduces mitochondrial membrane potential and ATP production., PMID:39821719
Impact of Long-Term Cannabidiol (CBD) Treatment on Mouse Kidney Transcriptome., PMID:39766907
Integrated hepatic transcriptomics and metabolomics identify Pck1 as a key factor in the broad dysregulation induced by vehicle pollutants., PMID:39734207
Salvianolic acid C promotes renal gluconeogenesis in fibrotic kidneys through PGC1α., PMID:39700761
Garcinol enriched fraction of Garcinia morella (Gaertn.) Desr. fruit rind improves gut health and reduces the risk of nonalcoholic fatty liver disease by regulating PCK1/ACC/SREBP1/FASn pathway in a mouse model., PMID:39577934
Effects of dechlorane plus on hepatic pathology, metabolic health and gut microbiota in male mice., PMID:39551218
Resveratrol attenuates Cr(VI)-induced disorders of glycolipid metabolism by regulating HNF1b/GPX1 in mice., PMID:39542080
Exploring the Molecular Mechanisms underlying SADI-S Improves Glucose Metabolism in Type 2 Diabetic Rats through Liver Transcriptomics and Proteomics Analysis., PMID:39499038
SIRT2 Alleviates Inflammatory Response, Apoptosis, and ECM Degradation in Osteoarthritic Chondrocytes by Stabilizing PCK1., PMID:39463224
Transcriptome Analysis Reveals the Early Development in Subcutaneous Adipose Tissue of Laiwu Piglets., PMID:39457885
ZBED3 exacerbates hyperglycemia by promoting hepatic gluconeogenesis through CREB signaling., PMID:39454821
Porcine reproductive and respiratory syndrome virus activates lipid synthesis through a ROS-dependent AKT/PCK1/INSIG/SREBPs axis., PMID:39433189
Ozone-Induced Lung Injury are Mediated Via PPAR-Mediated Ferroptosis in Mice., PMID:39370454
Small molecules targeting selective PCK1 and PGC-1α lysine acetylation cause anti-diabetic action through increased lactate oxidation., PMID:39341205
GSM1 Requires Hap4 for Expression and Plays a Role in Gluconeogenesis and Utilization of Nonfermentable Carbon Sources., PMID:39336719
Altered hepatic metabolic landscape and insulin sensitivity in response to pulmonary tuberculosis., PMID:39331683
Disturbed function of TBL1X has a differential effect on T3-regulated gene expression in two human liver cell models., PMID:39316725
Fads2 knockout mice reveal that ALA prevention of hepatic steatosis is dependent on delta-6 desaturase activity., PMID:39303984
Key Disease-Related Genes and Immune Cell Infiltration Landscape in Inflammatory Bowel Disease: A Bioinformatics Investigation., PMID:39273699
Heat Stress Induces Alterations in Gene Expression of Actin Cytoskeleton and Filament of Cellular Components Causing Gut Disruption in Growing-Finishing Pigs., PMID:39272260
Silencing of PCK1 mitigates the proliferation and migration of vascular smooth muscle cells and vascular intimal hyperplasia by suppressing STAT3/DRP1-mediated mitochondrial fission., PMID:39262325
Co-exposure of polyvinyl chloride microplastics with cadmium promotes nonalcoholic fatty liver disease in female ducks through oxidative stress and glycolipid accumulation., PMID:39182342
Phosphoenolpyruvate carboxykinase-2 (PCK2) is a therapeutic target in triple-negative breast cancer., PMID:39177932
Identifying the importance of PCK1 in maintaining ileal epithelial barrier integrity in Crohn's disease., PMID:39159791
Plantaginis Semen Ameliorates Hyperuricemia Induced by Potassium Oxonate., PMID:39126116
IL-10 Enhances the Inhibitory Effect of Adipose-Derived Stromal Cells on Insulin Resistance/Liver Gluconeogenesis by Treg Cell Induction., PMID:39125659
For research use only. Not for human or drug use.
