Catalog No.
YHE12601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr1550-Cys1791
Predicted molecular weight
53.23 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P35556
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Fibrillin-2, FBN2
Possible break-down of redox homeostasis in Beals-Hecht syndrome., PMID:40436996
Embryonic reprogramming of the tumor vasculature reveals targets for cancer therapy., PMID:40096611
Familial exudative vitreoretinopathy caused by CTNNB1 gene de novo mutation in a Chinese family: a case report., PMID:40011896
FBN2 promotes the proliferation, mineralization, and differentiation of osteoblasts to accelerate fracture healing., PMID:39924543
FBN2 pathogenic mutation in congenital contractural arachnodactyly with severe skeletal manifestations., PMID:39911746
Therapeutic effects of Mudan granules on diabetic retinopathy: Mitigating fibrogenesis caused by FBN2 deficiency and inflammation associated with TNF-α elevation., PMID:39490708
Screening and expression validation of key proteins for secondary hair follicle growth in cashmere goats based on iTRAQ quantitative proteomics technology., PMID:39474271
Whole-exome sequencing uncovers the genetic complexity of bicuspid aortic valve in families with early-onset complications., PMID:39226896
Extracellular Matrix Protein Signatures of the Outer and Inner Zones of the Rat Adrenal Cortex., PMID:39018382
Whole -genome survival analysis of 144 286 people from the UK Biobank identifies novel loci associated with blood pressure., PMID:39011893
Investigation of coagulation and proteomics profiles in symptomatic feline hypertrophic cardiomyopathy and healthy control cats., PMID:38970022
High-Throughput Genomics Identify Novel FBN1/2 Variants in Severe Neonatal Marfan Syndrome and Congenital Heart Defects., PMID:38791509
Genotype-phenotype profile of global ASPH-associated ectopia lentis and clinical findings from a Chinese cohort., PMID:38788814
FBN2 pathogenic variants in congenital contractural arachnodactyly with severe cardiovascular manifestations., PMID:38602424
Effect of Fibrillin-2 on Differentiation into Periodontal Ligament Stem Cell-Like Cells Derived from Human-Induced Pluripotent Stem Cells., PMID:38534877
HOTAIR/miR-1277-5p/FBN2 signaling axis is involved in recurrent spontaneous abortion by regulating the growth, migration, and invasion of HTR-8/SVneo cells†., PMID:38401166
Novel variant of FBN2 in a patient with congenital contractual arachnodactyly., PMID:38326314
Identification of Six Pathogenic Genes for Tibetan Familial Ventricular Septal Defect by Whole Exome Sequencing., PMID:38215673
De novo variants underlying monogenic syndromes with intellectual disability in a neurodevelopmental cohort from India., PMID:38114583
Quercetin antagonized advanced glycated end products induced apoptosis and functional inhibition of fibroblasts from the prolapsed uterosacral ligament., PMID:38044121
Hi-BDiSCO: folding 3D mesoscale genome structures from Hi-C data using brownian dynamics., PMID:38015443
Genetic models of fibrillinopathies., PMID:37972149
Author Correction: Intravitreal injection of fibrillin 2 (Fbn2) recombinant protein for therapy of retinopathy in a retina-specific Fbn2 knock-down mouse model., PMID:37968571
A Novel Splice Site Mutation in the FBN2 Gene in a Chinese Family with Congenital Contractural Arachnodactyly., PMID:37962692
Genetic testing and diagnostic strategies of fetal skeletal dysplasia: a preliminary study in Wuhan, China., PMID:37875969
Hmga1-overexpressing lentivirus protects against osteoporosis by activating the Wnt/β-catenin pathway in the osteogenic differentiation of BMSCs., PMID:37555233
Mutation in mitral valve prolapse susceptible gene DCHS1 causes familial mitral annular disjunction., PMID:37399314
A comprehensive analysis of FBN2 in bladder cancer: A risk factor and the tumour microenvironment influencer., PMID:37337404
Coexistence of MRCS syndrome, extremely long axis and exfoliation syndrome: a case report and literature review., PMID:37254066
Impact of mini-driver genes in the prognosis and tumor features of colorectal cancer samples: a novel perspective to support current biomarkers., PMID:37214090
Proteomic profiling of retina and retinal pigment epithelium combined embryonic tissue to facilitate ocular disease gene discovery., PMID:37191732
Assessment of fibrillin-2 and elastin gene polymorphisms in patients with a traumatic Achilles tendon rupture: Is Achilles tendon rupture a genetic disease?, PMID:37140249
Intravitreal injection of fibrillin 2 (Fbn2) recombinant protein for therapy of retinopathy in a retina-specific Fbn2 knock-down mouse model., PMID:37100863
Proteomic profiling of retina and retinal pigment epithelium combined embryonic tissue to facilitate ocular disease gene discovery., PMID:36993571
Integration of Mendelian randomisation and systems biology models to identify novel blood-based biomarkers for stroke., PMID:36958462
Case report: Identification of novel fibrillin-2 variants impacting disulfide bond and causing congenital contractural arachnodactyly., PMID:36936417
Utility of whole-exome sequencing for patients with multiple congenital anomalies with or without intellectual disability/developmental delay in East Asia population., PMID:36849876
Genome-wide identification of the fibrillin gene family in chickpea (Cicer arietinum L.) and its response to drought stress., PMID:36805507
Whole-genome sequencing analysis in families with recurrent pregnancy loss: A pilot study., PMID:36800380
Molecular characterization of physis tissue and hormonal profiles of female rats neonatally exposed to low-dose bisphenol A., PMID:36779543
FOXD1 is required for 3D patterning of the kidney interstitial matrix., PMID:36335435
Identification of an Epigenetic Signature for Coronary Heart Disease in Postmenopausal Women's PBMC DNA., PMID:36032780
Experimental evidence of the genetic hypothesis on the etiology of bicuspid aortic valve aortopathy in the hamster model., PMID:36003906
Cancer-Associated Stromal Fibroblast-Derived Transcriptomes Predict Poor Clinical Outcomes and Immunosuppression in Colon Cancer., PMID:35991839
Case Report: A Novel Homozygous Missense Variant of FBN3 Supporting It Is a New Candidate Gene Causative of a Bardet-Biedl Syndrome-Like Phenotype., PMID:35910214
Analysis of Competitive Endogenous Mechanism and Survival Prognosis of Serum Exosomes in Ovarian Cancer Patients Based on Sequencing Technology and Bioinformatics., PMID:35910206
Carrying both COL1A2 and FBN2 gene heterozygous mutations results in a severe skeletal clinical phenotype: an affected family., PMID:35804365
[A novel splicing acceptor variant of the FBN2 gene contributes to a case of congenital contractural arachnodactyly]., PMID:35598270
Exploring the association between specific genes and the onset of idiopathic scoliosis: a systematic review., PMID:35590413
For research use only. Not for human or drug use.
