Catalog No.
YHE08301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Pro376
Predicted molecular weight
44.93 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P35237
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CAP, PI6, PTI, PI-6, Cytoplasmic antiproteinase, Serpin B6, Peptidase inhibitor 6, SERPINB6, Placental thrombin inhibitor
Differential expression of cardiometabolic and inflammation markers and signaling pathways between overweight/obese Qatari adults with high and low plasma salivary α-amylase activity., PMID:39411310
Amplification of Inflammation by Lubricin Deficiency Implicated in Incident, Erosive Gout Independent of Hyperuricemia., PMID:36457235
The Investigation of Protein Profile and Meat Quality in Bovine Longissimus thoracic Frozen under Different Temperatures by Data-Independent Acquisition (DIA) Strategy., PMID:35741989
Serpin Signatures in Prion and Alzheimer's Diseases., PMID:35416570
The role of amygdala neuropsin/serpinb6 pathway in the regulation of gastric hypersensitivity and anxiety by electroacupuncture., PMID:35179294
Genomewide Association Analyses of Lactation Persistency and Milk Production Traits in Holstein Cattle Based on Imputed Whole-Genome Sequence Data., PMID:34828436
Mice heterozygous for the Serpinb6a null mutation show deficits in central auditory function after acoustic trauma., PMID:34554936
Identification of Hearing Loss-Associated Variants of PTPRQ, MYO15A, and SERPINB6 in Pakistani Families., PMID:33997018
Dutomycin Induces Autophagy and Apoptosis by Targeting the Serine Protease Inhibitor SERPINB6., PMID:33517652
Increased susceptibility to acoustic trauma in a mouse model of non-syndromic sensorineural deafness, DFNB91., PMID:33073422
A proteomic-based approach for the search of biomarkers in Iberian wild deer (Cervus elaphus) as indicators of meat quality., PMID:31228583
Cathepsin G Inhibition by Serpinb1 and Serpinb6 Prevents Programmed Necrosis in Neutrophils and Monocytes and Reduces GSDMD-Driven Inflammation., PMID:31216481
Genetic Aetiology of Nonsyndromic Hearing Loss in Moravia-Silesia., PMID:30344259
Sex-specific genetic predictors of Alzheimer's disease biomarkers., PMID:29967939
Synthesis, localization and possible function of serine (or cysteine) peptidase inhibitor, clade B, member 6a (Serpinb6a) in mouse submandibular gland., PMID:28455723
Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia., PMID:26956414
Bayesian phylogeny analysis of vertebrate serpins illustrates evolutionary conservation of the intron and indels based six groups classification system from lampreys for ∼500 MY., PMID:26157611
Subtelomeric 6p25 deletion/duplication: Report of a patient with new clinical findings and genotype-phenotype correlations., PMID:25817395
Whole-exome sequencing reveals diverse modes of inheritance in sporadic mild to moderate sensorineural hearing loss in a pediatric population., PMID:25719458
Antibody-validated proteins in inflamed islets of fulminant type 1 diabetes profiled by laser-capture microdissection followed by mass spectrometry., PMID:25329145
Transcriptional profiling reveals molecular signatures associated with HIV permissiveness in Th1Th17 cells and identifies peroxisome proliferator-activated receptor gamma as an intrinsic negative regulator of viral replication., PMID:24359430
Absence of SERPINB6A causes sensorineural hearing loss with multiple histopathologies in the mouse inner ear., PMID:23669344
Proteomic analysis on the alteration of protein expression in the early-stage placental villous tissue of electromagnetic fields associated with cell phone exposure., PMID:23420827
Identification of proteins expressed differently among surgically resected stage I lung adenocarcinomas., PMID:23200884
Differential gene expression of serine protease inhibitors in bovine ovarian follicle: possible involvement in follicular growth and atresia., PMID:21619581
Screening of 38 genes identifies mutations in 62% of families with nonsyndromic deafness in Turkey., PMID:21117948
A truncating mutation in SERPINB6 is associated with autosomal-recessive nonsyndromic sensorineural hearing loss., PMID:20451170
[Colorectal cancer 2D-proteomics: identification of altered protein expression]., PMID:19425502
In GnRH antagonist/rec-FSH stimulated cycles, advanced endometrial maturation on the day of oocyte retrieval correlates with altered gene expression., PMID:19176542
Genome-scale RNAi screen for host factors required for HIV replication., PMID:18976975
SerpinB6 is an inhibitor of kallikrein-8 in keratinocytes., PMID:17761692
Analysis of vertebrate genomes suggests a new model for clade B serpin evolution., PMID:16305753
Expression of serpinb6 serpins in germ and somatic cells of mouse gonads., PMID:16175637
The ovalbumin serpins revisited: perspective from the chicken genome of clade B serpin evolution in vertebrates., PMID:16055559
Targeted disruption of SPI3/Serpinb6 does not result in developmental or growth defects, leukocyte dysfunction, or susceptibility to stroke., PMID:15082799
Intracellular serpin SERPINB6 (PI6) is abundantly expressed by human mast cells and forms complexes with beta-tryptase monomers., PMID:14670919
A retained selection cassette increases reporter gene expression without affecting tissue distribution in SPI3 knockout/GFP knock-in mice., PMID:12872246
Distribution of serine proteinase inhibitor, clade B, member 6 (Serpinb6) in the adult mouse brain., PMID:12638128
Comparison of human chromosome 6p25 with mouse chromosome 13 reveals a greatly expanded ov-serpin gene repertoire in the mouse., PMID:11863365
For research use only. Not for human or drug use.
