Catalog No.
YHE07401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Gln290
Predicted molecular weight
35.28 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P35219
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Carbonic anhydrase VIII, CA-VIII, Carbonic anhydrase-related protein, CA8, CARP, CALS
Effects of p53 on the Regulation of Carbonic Anhydrase 8 in Human Colorectal Cancer Cells: Interaction Between p53 and Sp1., PMID:40387560
Potential drug targets for ovarian cancer identified through Mendelian randomization and colocalization analysis., PMID:39972314
Causal Relationships Between Epilepsy, Anti-Epileptic Drugs, and Serum Vitamin D and Vitamin D Binding Protein: A Bidirectional and Drug Target Mendelian Randomization Study., PMID:39703113
Streamlining heterologous expression of top carbonic anhydrases in Escherichia coli: bioinformatic and experimental approaches., PMID:38956607
Clinical and Molecular Spectrum of Autosomal Recessive CA8-Related Cerebellar Ataxia., PMID:38581205
Effects of down-regulated carbonic anhydrase 8 on cell survival and glucose metabolism in human colorectal cancer cell lines., PMID:38571370
Unveiling Novel Urease Inhibitors for Helicobacter pylori: A Multi-Methodological Approach from Virtual Screening and ADME to Molecular Dynamics Simulations., PMID:38396647
Unveiling the genetic basis of Fusarium wilt resistance in chickpea using GWAS analysis and characterization of candidate genes., PMID:38327700
Detailed Analysis of ITPR1 Missense Variants Guides Diagnostics and Therapeutic Design., PMID:37964426
The Combined Supplementation of AZOMITE and Citric Acid Promoted the Growth, Intestinal Health, Antioxidant, and Resistance against Aeromonas hydrophila for Largemouth Bass, Micropterus salmoides., PMID:37881475
Anticonvulsant Profile of Selected Medium-Chain Fatty Acids (MCFAs) Co-Administered with Metformin in Mice in Acute and Chronic Treatment., PMID:37175220
Establishment of a nonshockable rhythm cardiac arrest model caused by asphyxia., PMID:36581829
Carbonic anhydrase XII as biomarker and therapeutic target in ovarian carcinomas., PMID:35901081
Altered glucose metabolism and its association with carbonic anhydrase 8 in Machado-Joseph Disease., PMID:35488942
A Proteomic Landscape of Candida albicans in the Stepwise Evolution to Fluconazole Resistance., PMID:35343782
Lack of leaf carbonic anhydrase activity eliminates the C4 carbon-concentrating mechanism requiring direct diffusion of CO2 into bundle sheath cells., PMID:35233800
Short DNA/RNA heteroduplex oligonucleotide interacting proteins are key regulators of target gene silencing., PMID:33928345
Development and validation of a four-lipid metabolism gene signature for diagnosis of pancreatic cancer., PMID:33386701
Reversion mutation of cDNA CA8-204 minigene construct produces a truncated functional peptide that regulates calcium release in vitro and produces profound analgesia in vivo., PMID:33247772
Novel homozygous variant of carbonic anhydrase 8 gene expanding the phenotype of cerebellar ataxia, mental retardation, and disequilibrium syndrome subtype 3., PMID:32808436
Expression and Functional Study of Single Mutations of Carbonic Anhydrase 8 in Neuronal Cells., PMID:32583043
Gene expression profiles for low-dose exposure to diethyl phthalate in rodents and humans: a translational study with implications for breast carcinogenesis., PMID:32341500
Paraneoplastic cerebellar degeneration in a patient with breast cancer associated with carbonic anhydrase-related protein VIII autoantibodies., PMID:32325285
Structural Characterization of Carbonic Anhydrase VIII and Effects of Missense Single Nucleotide Variations to Protein Structure and Function., PMID:32316137
A novel immunochromatographic assay using ultramarine blue particles as visible label for quantitative detection of hepatitis B virus surface antigen., PMID:31948577
CA8 promotes RCC proliferation and migration though its expression level is lower in tumor compared to adjacent normal tissue., PMID:31715371
Cerebellar ataxia with normal intellect associated with a homozygous truncating variant in CA8., PMID:31693170
Profound analgesia is associated with a truncated peptide resulting from tissue specific alternative splicing of DRG CA8-204 regulated by an exon-level cis-eQTL., PMID:31199789
Protective roles of carbonic anhydrase 8 in Machado-Joseph Disease., PMID:31157458
Catalytically inactive carbonic anhydrase-related proteins enhance transport of lactate by MCT1., PMID:31033227
Aberrant IP3 receptor activities revealed by comprehensive analysis of pathological mutations causing spinocerebellar ataxia 29., PMID:30429331
In vitro and in vivo evaluation of cephalosporins for the treatment of Lyme disease., PMID:30254421
Carbonic anhydrase related protein expression in astrocytomas and oligodendroglial tumors., PMID:29792187
Human carbonic anhydrase-8 AAV8 gene therapy inhibits nerve growth factor signaling producing prolonged analgesia and anti-hyperalgesia in mice., PMID:29789638
Promoter analysis and transcriptional regulation of human carbonic anhydrase VIII gene in a MERRF disease cell model., PMID:29407793
Impact of human CA8 on thermal antinociception in relation to morphine equivalence in mice., PMID:28902707
Oncogenic roles of carbonic anhydrase 8 in human osteosarcoma cells., PMID:26711783
Carbonic Anhydrase 8 Expression in Purkinje Cells Is Controlled by PKCγ Activity and Regulates Purkinje Cell Dendritic Growth., PMID:26399641
Full-Genome Sequencing as a Basis for Molecular Epidemiology Studies of Bluetongue Virus in India., PMID:26121128
[An association study between gene polymorphism of the key enzyme's folacin metabolism pathway and plasmatic homocysteine levels in fertile woman]., PMID:25573130
Roles of carbonic anhydrase 8 in neuronal cells and zebrafish., PMID:24794067
Regional TNFα mapping in the brain reveals the striatum as a neuroinflammatory target after ventricular fibrillation cardiac arrest in rats., PMID:24530249
Effects of carbonic anhydrase-related protein VIII on human cells harbouring an A8344G mitochondrial DNA mutation., PMID:24476000
Carbonic anhydrase-related protein VIII antibodies and paraneoplastic cerebellar degeneration., PMID:24446689
Design and high-level expression of a hybrid antimicrobial peptide LF15-CA8 in Escherichia coli., PMID:24281395
Evaluation of glycodendron and synthetically modified dextran clearing agents for multistep targeting of radioisotopes for molecular imaging and radioimmunotherapy., PMID:24219178
Evolution and homoplasy at the Bem6 microsatellite locus in three sweetpotato whitefly (Bemisia tabaci) cryptic species., PMID:23819589
Restoring catalytic activity to the human carbonic anhydrase (CA) related proteins VIII, X and XI affords isoforms with high catalytic efficiency and susceptibility to anion inhibition., PMID:23200251
Altered expression of carbonic anhydrase-related protein XI in neuronal cells expressing mutant ataxin-3., PMID:23184527
Abnormal cerebellar development and ataxia in CARP VIII morphant zebrafish., PMID:23087022
For research use only. Not for human or drug use.
