Catalog No.
YHD78301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala524-Cys727
Predicted molecular weight
24.54 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P28331
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Complex I-75kD, CI-75kD, NDUFS1, NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Mitochondrial ribosomal protein L3 (MRPL3): An early diagnostic biomarker and potential molecular target in pancreatic cancer., PMID:40446627
Cold storage effects on mitochondrial bioenergetics and protein expression in human mesenchymal stromal cells., PMID:40380957
Single-cell proteomics analysis of human oocytes during GV-to-MI transition., PMID:40359387
Gestational THC exposure perturbates hippocampal mitochondrial respiration in the memory-impaired adolescent progeny: Is there a role for mitochondrial CB1 receptor?, PMID:40339229
Restoration of pp60Src Re-Establishes Electron Transport Chain Complex I Activity in Pulmonary Hypertensive Endothelial Cells., PMID:40332450
Identification of a disulfidptosis-related genes signature for diagnostic and immune infiltration characteristics in cervical cancer., PMID:40305445
Bioinformatics identification of shared signaling pathways and core targets linking Benzo[a]pyrene exposure to HCC progression., PMID:40174762
Analysis and identification of mitochondria-related genes associated with age-related hearing loss., PMID:40045222
AKAP1-STABILIZED TIMP-4 ATTENUATES ANG-II-INDUCED OXIDATIVE STRESS AND INFLAMMATION IN VASCULAR SMOOTH MUSCLE CELLS BY INACTIVATING THE NF-ΚB SIGNALING., PMID:39965635
NDUFA11 may be the disulfidptosis-related biomarker of ischemic stroke based on integrated bioinformatics, clinical samples, and experimental analyses., PMID:39877656
Identifying disulfidptosis-related biomarkers in epilepsy based on integrated bioinformatics and experimental analyses., PMID:39805370
F-53B disrupts energy metabolism by inhibiting the V-ATPase-AMPK axis in neuronal cells., PMID:39793390
A Novel Disulfidptosis-Related Risk Signature for Prognostic Prediction in Patients With Ewing Sarcoma., PMID:39775930
Burn-induced mitochondrial dysfunction in hepatocytes: The role of methylation-controlled J protein silencing., PMID:39760651
BCKDK loss impairs mitochondrial Complex I activity and drives alpha-synuclein aggregation in models of Parkinson's disease., PMID:39709505
Targeted Delivery and ROS-Responsive Release of Lutein Nanoassemblies Inhibit Myocardial Ischemia-Reperfusion Injury by Improving Mitochondrial Function., PMID:39583319
Dynamic responses of germination characteristics and antioxidant systems to alfalfa (Medicago sativa) seed aging based on transcriptome., PMID:39442418
Prediction of Protein Targets in Ovarian Cancer Using a Ru-Complex and Carbon Dot Drug Delivery Therapeutic Nanosystems: A Bioinformatics and µ-FTIR Spectroscopy Approach., PMID:39204341
Disulfidptosis: A Novel Prognostic Criterion and Potential Treatment Strategy for Diffuse Large B-Cell Lymphoma (DLBCL)., PMID:39000261
Significance and Possible Biological Mechanism for CLDN8 Downregulation in Kidney Renal Clear Cell Carcinoma Tissues., PMID:38993257
m6A methylation of RNF43 inhibits the progression of endometriosis through regulating oxidative phosphorylation via NDUFS1., PMID:38988031
Comprehensive analysis of disulfidptosis-related genes reveals the effect of disulfidptosis in ulcerative colitis., PMID:38977802
Cardiomyocyte βII spectrin plays a critical role in maintaining cardiac function by regulating mitochondrial respiratory function., PMID:38832923
Association between NDUFS1 from urinary extracellular vesicles and decreased differential renal function in children with ureteropelvic junction obstruction., PMID:38720274
Phloretin prolongs lifespan of Caenorhabditis elegans via inhibition of NDUFS1 and NDUFS6 at mitochondrial complex Ⅰ., PMID:38705496
Targeted degradation of NDUFS1 by agrimol B promotes mitochondrial ROS accumulation and cytotoxic autophagy arrest in hepatocellular carcinoma., PMID:38697493
Combinatorial immune checkpoint blockade increases myocardial expression of NLRP-3 and secretion of H-FABP, NT-Pro-BNP, interleukin-1β and interleukin-6: biochemical implications in cardio-immuno-oncology., PMID:38322766
A Drosophila model of mitochondrial disease phenotypic heterogeneity., PMID:38304969
AKAP1 in Renal Patients with AHF to Reduce Ferroptosis of Cardiomyocyte., PMID:38286648
Study on the mechanism of arsenic-induced renal injury based on SWATH proteomics technology., PMID:38266420
Downregulation of SLC3A2 mediates immune evasion and accelerates metastasis in oral squamous cell carcinoma., PMID:37927242
Role of DNA methylation during recovery from spinal cord injury with and without β2-adrenergic receptor agonism., PMID:37488045
The combination of NDUFS1 with CD4+ T cell infiltration predicts favorable prognosis in kidney renal clear cell carcinoma., PMID:37469574
Yeast NDI1 reconfigures neuronal metabolism and prevents the unfolded protein response in mitochondrial complex I deficiency., PMID:37399212
Use of dual genomic sequencing to screen mitochondrial diseases in pediatrics: a retrospective analysis., PMID:36918699
ONC201 Suppresses Neuroblastoma Growth by Interrupting Mitochondrial Function and Reactivating Nuclear ATRX Expression While Decreasing MYCN., PMID:36675163
PHB2 promotes colorectal cancer cell proliferation and tumorigenesis through NDUFS1-mediated oxidative phosphorylation., PMID:36658121
Analysis of compound heterozygous and homozygous mutations found in peripheral subunits of human respiratory Complex I, NDUFS1, NDUFS2, NDUFS8 and NDUFV1, by modeling in the E. coli enzyme., PMID:36462614
Hyperbaric oxygen enhanced the chemotherapy of mitochondrial targeting molecule IR-780 in bladder cancer., PMID:36436092
Generation of an induced pluripotent stem cell line (IUFi002-A) from a Leigh syndrome patient carrying mutations in the NDUFS1 gene., PMID:36403546
Down regulation of NDUFS1 is involved in the progression of parenteral-nutrition-associated liver disease by increasing Oxidative stress., PMID:36402252
Proteomics-based molecular and functional characteristic profiling of muscle tissue in Triploid crucian carp., PMID:36349986
Conditions Conducive to the Glutathionylation of Complex I Subunit NDUFS1 Augment ROS Production following the Oxidation of Ubiquinone Linked Substrates, Glycerol-3-Phosphate and Proline., PMID:36290766
Proteomic profiling reveals dysregulated mitochondrial complex subunits responsible for myocardial toxicity induced by SiNPs., PMID:36198348
Dual Mode of Mitochondrial ROS Action during Reprogramming to Pluripotency., PMID:36142834
Solute exchange through gap junctions lessens the adverse effects of inactivating mutations in metabolite-handling genes., PMID:36107487
Triclocarban evoked neutrophil extracellular trap formation in common carp (Cyprinus carpio L.) by modulating SIRT3-mediated ROS crosstalk with ERK1/2/p38 signaling., PMID:36057428
Lip cyanosis as the first symptom of Leigh syndrome associated with mitochondrial complex I deficiency due to a compound heterozygous NDUFS1 mutation: A case report., PMID:36042640
Mitochondrial Ribosome Dysfunction in Human Alveolar Type II Cells in Emphysema., PMID:35884802
For research use only. Not for human or drug use.
