Catalog No.
YHD80401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr1197-Ser1403
Predicted molecular weight
26.09 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P28827
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Protein-tyrosine phosphatase mu, R-PTP-mu, PTPRL1, PTPRM, Receptor-type tyrosine-protein phosphatase mu
Loss of Tyrosine Phosphatase Mu Promotes Scoliosis Progression Through Osteopontin-α5β1 Integrin Signaling and PIPK1γ90 Activity., PMID:39940812
Proteomic and serological markers for diagnosing cardia gastric cancer and precursor lesions in a Chinese population., PMID:39455684
Monozygotic triplets with juvenile-onset autoimmunity and 18p microdeletion involving PTPRM., PMID:39359478
DNA methyltransferase 1 (DNMT1) promotes cyst growth and epigenetic age acceleration in autosomal dominant polycystic kidney disease., PMID:38782200
Genetic alterations in the neuronal development genes are associated with changes of the tumor immune microenvironment in pancreatic cancer., PMID:38495381
Genome-Wide Association Studies of 3 Distinct Recovery Phenotypes in Mild Ischemic Stroke., PMID:38181310
Role of protein tyrosine phosphatase receptor type M in epithelial ovarian cancer progression., PMID:37403117
A quantitative trait GWAS on lens thickness identifies novel risk loci on PTPRM in the narrow angle individuals susceptible to PACG., PMID:36927043
Deep next-generation proteomics and network analysis reveal systemic and tissue-specific patterns in Fabry disease., PMID:36863609
High-fiber-diet-related metabolites improve neurodegenerative symptoms in patients with obesity with diabetes mellitus by modulating the hippocampal-hypothalamic endocrine axis., PMID:36733447
Transcriptome Analysis Reveals Vimentin-Induced Disruption of Cell-Cell Associations Augments Breast Cancer Cell Migration., PMID:36552797
Determinants of receptor tyrosine phosphatase homophilic adhesion: Structural comparison of PTPRK and PTPRM extracellular domains., PMID:36436563
Complementary evolution of coding and noncoding sequence underlies mammalian hairlessness., PMID:36342464
Molecular mechanism of Afadin substrate recruitment to the receptor phosphatase PTPRK via its pseudophosphatase domain., PMID:36264065
Gene Profiling of a 3D Psoriatic Skin Model Enriched in T Cells: Downregulation of PTPRM Promotes Keratinocyte Proliferation through Excessive ERK1/2 Signaling., PMID:36139479
Identification of proline-rich protein 11 as a major regulator in mouse spermatogonia maintenance via an increase in BMI1 protein stability., PMID:35980531
Characterization of Poorly Cohesive and Signet Ring Cell Carcinomas and Identification of PTPRM as a Diagnostic Marker., PMID:35626106
CircRNA PTPRM Promotes Non-Small Cell Lung Cancer Progression by Modulating the miR-139-5p/SETD5 Axis., PMID:35491723
Yak miR-2285o-3p attenuates hypoxia-induced apoptosis by targeting caspase-3., PMID:34807998
BMI1 promotes spermatogonia proliferation through epigenetic repression of Ptprm., PMID:34739857
Detecting the selection signatures in Chinese Duroc,Landrace, Yorkshire, Liangshan, and Qingyu pigs., PMID:34606016
PTPRM methylation induced by FN1 promotes the development of glioblastoma by activating STAT3 signalling., PMID:34225581
The serine hydroxymethyltransferase-2 (SHMT2) initiates lymphoma development through epigenetic tumor suppressor silencing., PMID:33569544
High expression of PTPRM predicts poor prognosis and promotes tumor growth and lymph node metastasis in cervical cancer., PMID:32826853
PSMD11, PTPRM and PTPRB as novel biomarkers of pancreatic cancer progression., PMID:32663515
DDIAS promotes STAT3 activation by preventing STAT3 recruitment to PTPRM in lung cancer cells., PMID:31900385
Novel genetic associations with interferon in systemic lupus erythematosus identified by replication and fine-mapping of trait-stratified genome-wide screen., PMID:30685201
β1,6 GlcNAc branches-modified protein tyrosine phosphatase Mu attenuates its tyrosine phosphatase activity and promotes glioma cell migration through PLCγ-PKC pathways., PMID:30274773
The genomic landscape of small cell carcinoma of the esophagus., PMID:29728688
PTPRG and PTPRC modulate nilotinib response in chronic myeloid leukemia cells., PMID:29507701
Mutational Landscape and Gene Expression Patterns in Adult Acute Myeloid Leukemias with Monosomy 7 as a Sole Abnormality., PMID:27784745
Comprehensive protein tyrosine phosphatase mRNA profiling identifies new regulators in the progression of glioma., PMID:27586084
Effectors and potential targets selectively upregulated in human KRAS-mutant lung adenocarcinomas., PMID:27301828
Host genetic predictors of the kynurenine pathway of tryptophan catabolism among treated HIV-infected Ugandans., PMID:27088321
Identification of lung cancer oncogenes based on the mRNA expression and single nucleotide polymorphism profile data., PMID:26458310
Loss of PTPRM associates with the pathogenic development of colorectal adenoma-carcinoma sequence., PMID:25910225
Identification of receptor-type protein tyrosine phosphatase μ as a new marker for osteocytes., PMID:25850409
microRNA-103/107 Family Regulates Multiple Epithelial Stem Cell Characteristics., PMID:25639731
Regulation of development and cancer by the R2B subfamily of RPTPs and the implications of proteolysis., PMID:25223585
Copy number alterations of chromosomal regions enclosing protein tyrosine phosphatase receptor-like genes in colorectal cancer., PMID:25169130
DNA methylation of membrane-bound tyrosine phosphatase genes in acute lymphoblastic leukaemia., PMID:24045499
Protein tyrosine phosphatase µ (PTP µ or PTPRM), a negative regulator of proliferation and invasion of breast cancer cells, is associated with disease prognosis., PMID:23185569
Protein tyrosine phosphatase receptor-like genes are frequently hypermethylated in sporadic colorectal cancer., PMID:23096495
Single cell molecular recognition of migrating and invading tumor cells using a targeted fluorescent probe to receptor PTPmu., PMID:22987116
Whole-exome sequencing uncovers frequent GNAS mutations in intraductal papillary mucinous neoplasms of the pancreas., PMID:22355676
Non-housekeeping genes expressed in human trabecular meshwork cell cultures., PMID:22312193
Replication study of 10 genes showing evidence for association with multiple sclerosis: validation of TMEM39A, IL12B and CBLB [correction of CLBL] genes., PMID:22194214
RPTPμ tyrosine phosphatase promotes adipogenic differentiation via modulation of p120 catenin phosphorylation., PMID:21998202
Analyses of porcine public SNPs in coding-gene regions by re-sequencing and phenotypic association studies., PMID:21107721
Trait-stratified genome-wide association study identifies novel and diverse genetic associations with serologic and cytokine phenotypes in systemic lupus erythematosus., PMID:20659327
For research use only. Not for human or drug use.
