Catalog No.
YHD80601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Lys292
Predicted molecular weight
34.71 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P28845
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
HSD11, HSD11L, 11-beta-HSD1, 11-DH, Corticosteroid 11-beta-dehydrogenase isozyme 1, 11-beta-hydroxysteroid dehydrogenase 1, HSD11B1, SDR26C1, Short chain dehydrogenase/reductase family 26C member 1
Erchen Decoction ameliorates the rat model of polycystic ovary syndrome by regulating the steroid biosynthesis pathway., PMID:40446578
Increased HSD11β1 Expression in Human Leiomyomatous Uteri: Implication for Enhanced Glucocorticoid Signaling., PMID:40290045
Large-scale plasma proteomics uncovers novel targets linking ambient air pollution and depression., PMID:40108257
Rno-miR-130b Attenuates Lipid Accumulation Through Promoting Apoptosis and Inhibiting Differentiation in Rat Intramuscular Adipocytes., PMID:40003868
Bisphenol B restrains rat leydig cell function via H3K27me3/H3K9me3 histone modifications., PMID:39919587
Effects of the combination of Epimedium brevicornum Maxim, Ligustrum lucidum Ait and Dexamethasone on asthmatic rats by endogenous glucocorticoid pathway., PMID:39694426
Adipocyte associated glucocorticoid signaling regulates normal fibroblast function which is lost in inflammatory arthritis., PMID:39543086
[Molecular mechanism of high-altitude hypoxia-induced lipid metabolism disorder in mouse spleen tissue]., PMID:39523103
Per-and polyfluoroalkyl substances and disrupted sleep: mediating roles of proteins., PMID:39512894
HSD11B1 overexpression in dendritic cells and stromal cells relates to endometriosis by inhibiting dendritic cell proliferation and maturation., PMID:39387602
Targeting osteoblastic 11β-HSD1 to combat high-fat diet-induced bone loss and obesity., PMID:39362888
Glucocorticoid excess alters metabolic rate and substrate utilisation via 11β-HSD1., PMID:39302000
Local Regulatory Changes of HSD11B1 and NR3C1 in the Follicular and Luteal Tissue During Experimentally Induced Ovulation in the Cow., PMID:39295165
Circulating inflammatory and immune response proteins and endometrial cancer risk: a nested case-control study and Mendelian randomization analyses., PMID:39278107
Upregulation of HSD11B1 promotes cortisol production and inhibits NK cell activation in pancreatic adenocarcinoma., PMID:39276709
Ectoin attenuates cortisone-induced skin issues by suppression GR signaling and the UVB-induced overexpression of 11β-HSD1., PMID:39222375
Fast and reliable quantification of aldosterone, cortisol and cortisone via LC-MS/MS to study 11β-hydroxysteroid dehydrogenase activities in primary cell cultures., PMID:39214289
Histological Characteristics of Follicles, Reproductive Hormones and Transcriptomic Analysis of White King Pigeon Illuminated with Red Light., PMID:39199854
Psoriatic skin transcript phenotype: androgen/estrogen and cortisone/cortisol imbalance with increasing DNA damage response., PMID:39180588
Association of polymorphisms of HSD11B1 and ACE genes with trachoma disease., PMID:39049478
Network Pharmacology and Molecular Docking Validation to Explore the Pharmacological Mechanism of Zhuling Decoction against Nephrotic Syndrome., PMID:38910482
The Role of microRNA in the Regulation of Cortisol Metabolism in the Adipose Tissue in the Course of Obesity., PMID:38791098
Early life stress unravels epistatic genetic associations of cortisol pathway genes with depression., PMID:38759498
Exploring the Molecular Mechanisms of Huaier on Modulating Metabolic Reprogramming of Hepatocellular Carcinoma: A Study based on Network Pharmacology, Molecular Docking and Bioinformatics., PMID:38747231
Identification of Potential Biomarkers for Major Depressive Disorder: Based on Integrated Bioinformatics and Clinical Validation., PMID:38722514
Deoxynivalenol Inhibits Progenitor Leydig Cell Development by Stimulating Mitochondrial Fission in Rats., PMID:38656193
Association of seasonal changes in circulating cortisol concentrations with the expression of cortisol biosynthetic enzymes and a glucocorticoid receptor in the blubber of common bottlenose dolphin., PMID:38593942
Age-related increase in the expression of 11β-hydroxysteroid dehydrogenase type 1 in the hippocampus of male rhesus macaques., PMID:38560025
Abnormal DNA methylation within HPA-axis genes years after paediatric critical illness., PMID:38395991
Microbiota modulates the steroid response to acute immune stress in male mice., PMID:38361932
The impact of parental and developmental stress on DNA methylation in the avian hypothalamic-pituitary-adrenal axis., PMID:38343177
Deciphering the role of alternative splicing as a potential regulator in fat-tail development of sheep: a comprehensive RNA-seq based study., PMID:38287039
The intrafollicular concentrations of biologically active cortisol in women rise abruptly shortly before ovulation and follicular rupture., PMID:38268234
Integrating network pharmacology and animal experimental validation to investigate the action mechanism of oleanolic acid in obesity., PMID:38246999
Perfluorotetradecanoic acid exposure to adult male rats stimulates corticosterone biosynthesis but inhibits aldosterone production., PMID:38205621
Activation of endogenous glucocorticoids by HSD11B1 inhibits the antitumor immune response in renal cancer., PMID:38170044
Predisposing factors for adrenal crisis in chronic adrenal insufficiency: a case-control study., PMID:38006230
11-beta-hydroxysteroid dehydrogenase type 1 (HSD11B1) gene expression in muscle is linked to reduced skeletal muscle index in sarcopenic patients., PMID:37943405
Metabolomics Reveals Molecular Signatures for Psoriasis Biomarkers and Drug Targets Discovery., PMID:37941849
Local glucocorticoid synthesis regulates house dust mite-induced airway hypersensitivity in mice., PMID:37936704
N6-methyladenosine demethylase FTO related to hyperandrogenism in PCOS via AKT pathway., PMID:37931646
G6PC1 and G6PC2 influence G6P flux but not HSD11B1 activity., PMID:37855366
Hepatic-Specific FGF21 Knockout Abrogates Ovariectomy-Induced Obesity by Reversing Corticosterone Production., PMID:37834368
Quantitative Analysis of mRNA and Protein Expression Levels of Aldo-Keto Reductase and Short-Chain Dehydrogenase/Reductase Isoforms in the Human Intestine., PMID:37722844
11β-Hydroxysteroid Dehydrogenase Type 1 Facilitates Osteoporosis by Turning on Osteoclastogenesis through Hippo Signaling., PMID:37496992
SNHG3/miR-330-5p/HSD11B1 Alleviates Myocardial Ischemia-reperfusion Injury by Regulating the ERK/p38 Signaling Pathway., PMID:37488754
Tumors produce glucocorticoids by metabolite recycling, not synthesis, and activate Tregs to promote growth., PMID:37471141
Bisphenol S stimulates Leydig cell proliferation but inhibits differentiation in pubertal male rats through multiple mechanisms., PMID:37357847
Changes in the liver of Tinca tinca under successive domestication using an integrated multi-omics approach., PMID:37354750
Progesterone modulates HSD11B1-mediated cortisol production in luteinized bovine granulosa cells., PMID:37344443
For research use only. Not for human or drug use.
