Catalog No.
YHD72801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala20-Pro135
Predicted molecular weight
40.25 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P27037
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ACVR2, ACTRIIA, ACTR-IIA, Activin receptor type IIA, ACVR2A, Activin receptor type-2A
ACVR2A facilitates trophoblast cell invasion through TCF7/c-JUN pathway in pre-eclampsia progression., PMID:40444773
Acute regulation of murine adipose tissue lipolysis and insulin resistance by the TGFβ superfamily protein GDF3., PMID:40360531
ACVR2A attenuation impacts lactate production and hyperglycolytic conditions attracting regulatory T cells in hepatocellular carcinoma., PMID:40139191
Detection of Microsatellite Instability in Endometrial Carcinoma Using a Novel Homopolymer Assay., PMID:40033864
Assessing genetic conservation of human sociability-linked genes in C. elegans., PMID:39982572
A Novel ACVR2A::RAF1 Fusion in Spindle Cell Sarcoma., PMID:39950347
The First Evidence for the Role of ACVR2A Gene Fetal Genotype in Preeclampsia Susceptibility., PMID:39898504
Inhibition of Endothelial-Mesenchymal Transition Mediated by Activin Receptor Type IIA Attenuates Valvular Injury Induced by Group A Streptococcus in Lewis Rats., PMID:39862082
Recapitulating the adenoma-carcinoma sequence by selection of four spontaneous oncogenic mutations in mismatch-repair-deficient human colon organoids., PMID:39487295
Activin A plays an essential role in migration and proliferation of hepatic stellate cells via Smad3 and calcium signaling., PMID:39223291
Circular RNA ACVR2A promotes the progression of hepatocellular carcinoma through mir-511-5p targeting PI3K-Akt signaling pathway., PMID:39107843
Identification of 8 candidate microsatellite instability loci in colorectal cancer and validation of the ACVR2A mechanism in the tumor progression., PMID:38898042
BMP7 promotes cardiomyocyte regeneration in zebrafish and adult mice., PMID:38678558
Echinacoside Exerts Antihepatic Fibrosis Effects in High-Fat Mice Model by Modulating the ACVR2A-Smad Pathway., PMID:38366962
The Activation of the Fibrodysplasia Ossificans Progressiva-Inducing ALK2-R206H Mutant Depends on the Distinct Homo-Oligomerization Patterns of ACVR2B and ACVR2A., PMID:38334613
Genomic characterization and immunotherapy for microsatellite instability-high in cholangiocarcinoma., PMID:38281914
Genomic characterization of vulvar squamous cell carcinoma reveals differential gene expression based on clinical outcome., PMID:38086165
Genetic variants in myostatin and its receptors promote elite athlete status., PMID:38082252
Use of AgomiR and AntagomiR technologies to alter satellite cell proliferation in vitro, miRNA expression, and muscle fiber hypertrophy in intrauterine growth-restricted lambs., PMID:38028550
Genome-wide characterization of the TGF-β gene family and their expression in different tissues during tail regeneration in the Schlegel's Japanese gecko Gekko japonicus., PMID:37984573
Bone morphogenetic protein 6 induces downregulation of pentraxin 3 expression in human granulosa lutein cells in women with polycystic ovary syndrome., PMID:37930517
Comprehensive Analysis of the Transcriptome-Wide m6A Methylome in Shaziling Pig Testicular Development., PMID:37833923
RNA Sequencing and Related Differential Gene Expression Analysis in a Mouse Model of Emphysema Induced by Tobacco Smoke Combined with Elastin Peptides., PMID:37810372
Genome-wide analysis of BMP/GDF family and DAP-seq of YY1 suggest their roles in Cynoglossus semilaevis sexual size dimorphism., PMID:37793513
Bioinformatics Analysis of the Genetic and Epigenetic Alterations of Bone Morphogenetic Protein Receptors in Metastatic Breast Cancer., PMID:37486509
Activin A/ACVR2A axis inhibits epithelial-to-mesenchymal transition in colon cancer by activating SMAD2., PMID:37378449
FKBP12 inhibits hepcidin expression by modulating BMP receptors interaction and ligand responsiveness in hepatocytes., PMID:37199280
Differences in DNA damage repair gene mutations between left- and right-sided colorectal cancer., PMID:37096801
Comparative Transcriptomic Analysis of Archival Human Vestibular Schwannoma Tissue from Patients with and without Tinnitus., PMID:37048724
Positive selection of somatically mutated clones identifies adaptive pathways in metabolic liver disease., PMID:37040760
Functional Testing of Bone Morphogenetic Protein (BMP) Pathway Variants Identified on Whole-Exome Sequencing in a Patient with Delayed-Onset Fibrodysplasia Ossificans Progressiva (FOP) Using ACVR1R206H -Specific Human Cellular and Zebrafish Models., PMID:36153796
Investigation of cell signalings and therapeutic targets in PTPRK-RSPO3 fusion-positive colorectal cancer., PMID:36129915
De novo mutations in the BMP signaling pathway in lambdoid craniosynostosis., PMID:35997807
Downregulation of miR-192 Alleviates Oxidative Stress-Induced Porcine Granulosa Cell Injury by Directly Targeting Acvr2a., PMID:35954205
Type II BMP and activin receptors BMPR2 and ACVR2A share a conserved mode of growth factor recognition., PMID:35643319
Evaluation of cfDNA as an early detection assay for dense tissue breast cancer., PMID:35589867
RNA sequence analysis identified bone morphogenetic protein-2 (BMP2) as a biomarker underlying form deprivation myopia., PMID:35494490
A minority of somatically mutated genes in pre-existing fatty liver disease have prognostic importance in the development of NAFLD., PMID:35474605
Homozygous Mutation of gsdf Causes Infertility in Female Nile Tilapia (Oreochromis niloticus)., PMID:35242110
Competition between type I activin and BMP receptors for binding to ACVR2A regulates signaling to distinct Smad pathways., PMID:35177083
The earliest events in BRAF-mutant colorectal cancer: exome sequencing of sessile serrated lesions with a tiny focus dysplasia or cancer reveals recurring mutations in two distinct progression pathways., PMID:35143042
The m6A methyltransferase METTL3 regulates muscle maintenance and growth in mice., PMID:35013323
Adaptive Immune Response Signaling Is Suppressed in Ly6Chigh Monocyte but Upregulated in Monocyte Subsets of ApoE-/- Mice - Functional Implication in Atherosclerosis., PMID:34987524
Circular RNA_0001073 (circ_0001073) Suppresses The Progression of Non-Small Cell Lung Cancer via miR-582-3p/RGMB Axis., PMID:34939762
Variant profiling of colorectal adenomas from three patients of two families with MSH3-related adenomatous polyposis., PMID:34843512
Comprehensive Analysis of the Expression of TGF-β Signaling Regulators and Prognosis in Human Esophageal Cancer., PMID:34725559
The Exploration of Poor Ovarian Response-Related Risk Factors: A Potential Role of Growth Differentiation Factor 8 in Predicting Ovarian Response in IVF-ET Patient., PMID:34630324
Extracellular vesicles from adipose tissue-derived stem cells alleviate osteoporosis through osteoprotegerin and miR-21-5p., PMID:34596354
Mesenchymal Stem Cell-Derived Exosomes Protect Muscle Loss by miR-145-5p Activity Targeting Activin A Receptors., PMID:34440938
Endometrial receptivity and implantation require uterine BMP signaling through an ACVR2A-SMAD1/SMAD5 axis., PMID:34099644
For research use only. Not for human or drug use.
