Catalog No.
YHD69301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Cys471-Thr629
Predicted molecular weight
19.73 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P26012
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ITGB8, Integrin beta-8
RORγt eTACs mediate oral tolerance and Treg induction., PMID:40298935
LGR6 modulates intervertebral disc degeneration through regulation of macrophage efferocytosis., PMID:40281518
FDA-approved Levophed as an alternative multitargeted therapeutic against cervical cancer transferase, cell cycle, and regulatory proteins., PMID:40209578
Immune checkpoint TIM-3 regulates microglia and Alzheimer's disease., PMID:40205047
Identification of Ferroptosis- and Hypoxia-related Genes in iPSC-derived Oligodendrocyte Precursor Cells from Multiple Sclerosis Patients., PMID:40127044
Radial glia integrin avb8 regulates cell autonomous microglial TGFβ1 signaling that is necessary for microglial identity., PMID:40121230
Integrative analysis of semaphorins family genes in colorectal cancer: implications for prognosis and immunotherapy., PMID:40103807
Exploring shared pathogenesis of multiple myeloma and osteoporosis via bioinformatic analysis., PMID:39943780
Fructo-Oligosaccharides Enhance the Expression of Genes Related to Focal Adhesion- and Inflammation-Pathways in Small Intestinal Absorptive Caco-2 Cells., PMID:39756968
Investigating the inflammatory mechanism of notoginsenoside R1 in Diabetic nephropathy via ITGB8 based on network pharmacology and experimental validation., PMID:39725889
Potential Biomarkers in Myocardial Fibrosis: A Bioinformatic Analysis., PMID:39699450
A novel ITGB8 transcript variant sustains ovarian cancer cell survival through genomic instability and altered ploidy on a mutant p53 background., PMID:39506768
MYO6 contributes to tumor progression and enzalutamide resistance in castration-resistant prostate cancer by activating the focal adhesion signaling pathway., PMID:39449086
A positive ReceptivaDx result for BCL6 does not correlate with abnormal ERA results or decreased expression of receptivity-associated markers: two sides of the endometrial receptivity coin in fertility evaluation and treatment., PMID:39419175
E74-like factor 4 promotes the proliferation, invasion, and migration of colorectal cancer cells via long non-coding RNA integrin subunit beta 8 antisense RNA 1-mediated histone H3 lysine 27 trimethylation modification., PMID:39325021
MAP3K8 is a potential therapeutic target in airway epithelial inflammation., PMID:39030600
Single-Cell RNA Sequencing Reveals Transcriptional Signatures and Cell-Cell Communication in Diabetic Retinopathy., PMID:38988068
Expression profiling and function analysis identified new genes regulating cumulus expansion and cumulus cell apoptosis in mouse oocytes., PMID:38949488
Construction and Bioinformatics Analysis of ceRNA Regulatory Networks in Idiopathic Pulmonary Fibrosis., PMID:38871957
Circ_0008571 modulates the phenotype of vascular smooth muscle cells by targeting miR-145-5p in intracranial aneurysms., PMID:38834101
Identification of Key Molecular Pathways and Associated Genes as Targets to Overcome Radiotherapy Resistance Using a Combination of Radiotherapy and Immunotherapy in Glioma Patients., PMID:38474320
Pericardial delta like non-canonical NOTCH ligand 1 (Dlk1) augments fibrosis in the heart through epithelial to mesenchymal transition., PMID:38328889
Screening of Candidate Inflammatory Markers of Epithelial Cells in Hepatocellular Carcinoma Based on Integration Analysis of TCGA/ICGC Databases and Single-cell Sequencing., PMID:38299418
Cerebral furin deficiency causes hydrocephalus in mice., PMID:38292192
Interaction of Integrin αvβ8 With Type I Collagen Promotes Squamous Cell Carcinoma Cell Motility via RAC1 Activation., PMID:37909974
APOE4 impairs the microglial response in Alzheimer's disease by inducing TGFβ-mediated checkpoints., PMID:37749326
Lactobacillus johnsonii N6.2 phospholipids induce immature-like dendritic cells with a migratory-regulatory-like transcriptional signature., PMID:37675983
Prognostic value and potential molecular mechanism of ITGB superfamily members in hepatocellular carcinoma., PMID:37603520
Cell softness reveals tumorigenic potential via ITGB8/AKT/glycolysis signaling in a mice model of orthotopic bladder cancer., PMID:37390491
Establishment and validation of a novel integrin-based prognostic gene signature that sub-classifies gliomas and effectively predicts immunosuppressive microenvironment., PMID:37096960
Convergent Genomic Signatures of Cashmere Traits: Evidence for Natural and Artificial Selection., PMID:36674681
LINC00472 inhibits cell migration by enhancing intercellular adhesion and regulates H3K27ac level via interacting with P300 in renal clear cell carcinoma., PMID:36371410
The prognostic and immune infiltration role of ITGB superfamily members in non-small cell lung cancer., PMID:36247270
Novel antigen-presenting cell imparts Treg-dependent tolerance to gut microbiota., PMID:36070798
Identification of HBEGF+ fibroblasts in the remission of rheumatoid arthritis by integrating single-cell RNA sequencing datasets and bulk RNA sequencing datasets., PMID:36068607
Integrated analysis of mRNA-single nucleotide polymorphism-microRNA interaction network to identify biomarkers associated with prostate cancer., PMID:35957689
Platelet-rich plasma promotes peripheral nerve regeneration after sciatic nerve injury., PMID:35900433
Single-cell profiling of microenvironment components by spatial localization in pancreatic ductal adenocarcinoma., PMID:35836806
Paradoxical role of β8 integrin on angiogenesis and vasculogenic mimicry in glioblastoma., PMID:35676251
Exosomal circDNER enhances paclitaxel resistance and tumorigenicity of lung cancer via targeting miR-139-5p/ITGB8., PMID:35396925
Integrin subunit beta 8 contributes to lenvatinib resistance in HCC., PMID:35238496
The β8 integrin cytoplasmic domain activates extracellular matrix adhesion to promote brain neurovascular development., PMID:35217866
Peri-implantation expression and regulation of ITGB8 in goat uterus., PMID:34973644
Cell-subpopulation alteration and FGF7 activation regulate the function of tendon stem/progenitor cells in 3D microenvironment revealed by single-cell analysis., PMID:34810035
Identification of Therapeutic Targets and Prognostic Biomarkers Among Integrin Subunits in the Skin Cutaneous Melanoma Microenvironment., PMID:34660316
lncRNA ITGB8-AS1 functions as a ceRNA to promote colorectal cancer growth and migration through integrin-mediated focal adhesion signaling., PMID:34371180
Long noncoding RNA HULC contributes to paclitaxel resistance in ovarian cancer via miR-137/ITGB8 axis., PMID:34250246
Eight novel susceptibility loci and putative causal variants in atopic dermatitis., PMID:34116867
Downregulation of circ_0037655 impedes glioma formation and metastasis via the regulation of miR-1229-3p/ITGB8 axis., PMID:34017919
Circ_0017956 promotes the proliferation and metastasis of non-small cell lung cancer through regulating miR-515-5p/ITGB8 axis., PMID:33945401
For research use only. Not for human or drug use.
