Catalog No.
YHD71201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly2-Pro187
Predicted molecular weight
23.44 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P26583
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
HMGB2, High mobility group protein 2, HMG-2, HMG2, High mobility group protein B2
Characterization of m6A-Related Genes in Tumor-Associated Macrophages for Prognosis, Immunotherapy, and Drug Prediction in Lung Adenocarcinomas Based on Machine Learning Algorithms., PMID:40474570
Pan-cancer analysis of phagocytosis regulators in female-specific cancers: a focus on HMGB2., PMID:40396172
Targeting HMGB2 acts as dual immunomodulator by bolstering CD8+ T cell function and inhibiting tumor growth in hepatocellular carcinoma., PMID:40315321
Phase separation of MRG15 delays cellular senescence., PMID:40312521
Changes in histone abundance and post-translational modifications in Rana [Lithobates] catesbeiana tissues during temperature-mediated thyroid hormone-induced metamorphosis., PMID:40262239
Hmgb2 improves astrocyte to neuron conversion by increasing the chromatin accessibility of genes associated with neuronal maturation in a proneuronal factor-dependent manner., PMID:40247387
Predictive and clinicopathological importance of HMGB2 in various carcinomas: a meta and bioinformatic approach., PMID:40164660
Targeting KPNB1 suppresses AML cells by inhibiting HMGB2 nuclear import., PMID:40082556
Targeting high mobility group protein B2 exerts antiproliferative effects in hypoxic pulmonary hypertension by modulating miR-21., PMID:39952300
Identification of increased dedifferentiation along the Prom1+ cancer cells in Müllerian adenosarcoma with sarcomatous overgrowth., PMID:39920368
HMGB2 knockdown ameliorates retinal ganglion cell injury by inhibiting NLRP3 inflammasome activation after retinal ischemia., PMID:39829613
Genome-Wide Analysis Reveals Key Genes and MicroRNAs Related to Pathogenic Mechanism in Wuchereria bancrofti., PMID:39770348
HMGA2 as a prognostic and immune biomarker in hepatocellular carcinoma: Comprehensive analysis of the HMG family and experiments validation., PMID:39591457
Cytoplasmic HMGB2 orchestrates CALR translocation in the course of immunogenic cell death., PMID:39585160
HMGB2 promotes smooth muscle cell proliferation through PPAR-γ/PGC-1α pathway-mediated glucose changes in aortic dissection., PMID:39531897
EUGENOL RESTRAINS ANGIOTENSIN II-INDUCED DEATH, INFLAMMATION AND FERROPTOSIS OF VASCULAR SMOOTH MUSCLE CELLS BY TARGETING STAT3/HMGB2 AXIS., PMID:39450921
HMGB2-induced calreticulin translocation required for immunogenic cell death and ferroptosis of cancer cells are controlled by the nuclear exporter XPO1., PMID:39354146
HMGB2 drives tumor progression and shapes the immunosuppressive microenvironment in hepatocellular carcinoma: insights from multi-omics analysis., PMID:39247201
The negative feedback loop of NF-κB/miR-202-5p/HMGB2 attenuates sepsis induced acute kidney injury., PMID:39226829
The role of HMGB2 in the immune response of Nile tilapia (Oreochromis niloticus) to streptococcal infection., PMID:39159774
Development of a biomarker-based platform for comprehensive skin characterization using minimally invasive skin sampling and quantitative real-time PCR., PMID:39141418
Manipulating host secreted protein gene expression: an indirect approach by HPV11/16 E6/E7 to suppress PBMC cytokine secretion., PMID:39095779
Structure and Functions of HMGB3 Protein., PMID:39062899
Targeting N4-acetylcytidine suppresses hepatocellular carcinoma progression by repressing eEF2-mediated HMGB2 mRNA translation., PMID:39030964
Quantitative Proteomics Provided Insights into the Protective Effects of Heat Acclimation on the Rat Hypothalamus after Exertional Heatstroke., PMID:38940089
Spatial transcriptomics reveals gene interactions and signaling pathway dynamics in rat embryos with anorectal malformation., PMID:38769159
HMGB2 is a biomarker associated with poor prognosis promoting radioresistance in glioma by targeting base excision repair pathway., PMID:38728871
Proteomic Analysis of Spatial Heterogeneity Identifies HMGB2 as Putative Biomarker of Tumor Progression in Adult-Type Diffuse Astrocytomas., PMID:38672598
Decreased Ubiquitination and Acetylation of Histones 3 and 4 Are Associated with Obesity-Induced Disorders of Spermatogenesis in Mice., PMID:38668519
The transcription factor HMGB2 indirectly regulates APRIL expression and Gd-IgA1 production in patients with IgA nephropathy., PMID:38622929
HMGB2 Release Promotes Pulmonary Hypertension and Predicts Severity and Mortality of Patients With Pulmonary Arterial Hypertension., PMID:38572649
HMGB2 Promotes De Novo Lipogenesis to Accelerate Hepatocyte Proliferation During Liver Regeneration., PMID:38544368
The Effect of HMGB1 and HMGB2 on Transcriptional Regulation Differs in Neuroendocrine and Adenocarcinoma Models of Prostate Cancer., PMID:38542079
The temporal protein signature analyses of developing human deciduous molar tooth germ., PMID:38522031
PRMT7-Dependent Transcriptional Activation of Hmgb2 Aggravates Severe Acute Pancreatitis by Promoting Acsl1-Induced Ferroptosis., PMID:38376246
Blocking the E2F transcription factor 1/high-mobility group box 2 pathway enhances the intervention effects of α-santalol on the malignant behaviors of liver cancer cells., PMID:38219975
Identification of aging-related genes in diagnosing osteoarthritis via integrating bioinformatics analysis and machine learning., PMID:38175691
HMGB2 Deficiency Mitigates Abdominal Aortic Aneurysm by Suppressing Ang-II-Caused Ferroptosis and Inflammation via NF-κβ Pathway., PMID:38148870
Ionizing radiation induces vascular smooth muscle cell senescence through activating NF-κB/CTCF/p16 pathway., PMID:38141838
The miR-221/222 cluster regulates hematopoietic stem cell quiescence and multipotency by suppressing both Fos/AP-1/IEG pathway activation and stress-like differentiation to granulocytes., PMID:37983263
HMGB2 upregulation promotes the progression of hepatocellular carcinoma cells through the activation of ZEB1/vimentin axis., PMID:37969822
HMGB2 is a potential diagnostic marker and therapeutic target for liver fibrosis and cirrhosis., PMID:37930124
Seven chromatin regulators as immune cell infiltration characteristics, potential diagnostic biomarkers and drugs prediction in hepatocellular carcinoma., PMID:37903974
Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation., PMID:37832549
Label-Free Quantitative Thermal Proteome Profiling Reveals Target Transcription Factors with Activities Modulated by MC3R Signaling., PMID:37804223
New Insights into the Role of HMGB2 in ST-Segment Elevation Myocardial Infarction., PMID:37727529
Correlation of serum HMGB1 and HMGB2 levels with clinical symptoms in allergic rhinitis children., PMID:37713866
HMGB2 regulates the differentiation and stemness of exhausted CD8+ T cells during chronic viral infection and cancer., PMID:37704621
Regulation of DNA damage and transcriptional output in the vasculature through a cytoglobin-HMGB2 axis., PMID:37573836
HMGB family proteins: Potential biomarkers and mechanistic factors in cardiovascular diseases., PMID:37437373
For research use only. Not for human or drug use.
