Catalog No.
YHD68701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Phe282-Ile384
Predicted molecular weight
38.94 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P25929
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
NPYY1, NPYR, NPY1R, NPY1-R, Neuropeptide Y receptor type 1
Neuropeptide Y receptors 1 and 2 as molecular targets in prostate and breast cancer therapy., PMID:40319656
Possible involvement of neuropeptide Y sub-receptor 1 (NPY-Y1) in the anti-viral response of SARS-CoV-2 infection in Syrian hamster., PMID:40189329
Targeting the NPY/NPY1R signaling axis in mutant p53-dependent pancreatic cancer impairs metastasis., PMID:40073121
Modulation of temporoammonic-CA1 synapses by neuropeptide Y is through Y1 receptors in mice., PMID:39951960
A single injection of neuropeptide QRFP in the lateral hypothalamus decreased food intake., PMID:39921588
Downregulation of the NPY-Y1R system in Grpr neurons results in mechanical and chemical hyperknesis in chronic itch., PMID:39827968
Exploring the Anxiolytic Potential of NPY by a Dipeptidyl Peptidase-IV Inhibitor in an Animal Model of PTSD., PMID:39626016
'The effect of neuropeptide Y1 receptor agonist on hypothalamic neurogenesis in rat experimental depression model'., PMID:39576364
Central administration of galanin-like peptide (GALP) causes short-term orexigenic effects in broilers: Mediatory role of NPY1 and D1 receptors., PMID:39551101
Phosphorylated NPY1R regulates phenotypic transition of vascular smooth muscle cells, inflammatory response and macrophage infiltration to promote intracranial aneurysm progression., PMID:39353356
Enhancing Cognitive Functions and Neuronal Growth through NPY1R Agonist and Ketamine Co-Administration: Evidence for NPY1R-TrkB Heteroreceptor Complexes in Rats., PMID:38667284
Potentiation of antidepressant effects: NPY1R agonist and ketamine synergy enhances TrkB signaling and neurogenesis in the ventral hippocampus., PMID:38626283
Enhanced neuronal survival and BDNF elevation via long-term co-activation of galanin 2 (GALR2) and neuropeptide Y1 receptors (NPY1R): potential therapeutic targets for major depressive disorder., PMID:38622072
Long-term enhancements in antidepressant efficacy and neurogenesis: Effects of intranasal co-administration of neuropeptide Y 1 receptor (NPY1R) and galanin receptor 2 (GALR2) agonists in the ventral hippocampus., PMID:38572811
The plasticity of neuropeptide Y-Y1 receptor system on Tac2 neurons contributes to mechanical hyperknesis during chronic itch., PMID:38164144
Endogenous μ-opioid-Neuropeptide Y Y1 receptor synergy silences chronic postoperative pain in mice., PMID:37649580
Transient cardiac electrophysiological changes in a rat model of subarachnoid haemorrhage: a brain-heart interaction., PMID:37337928
Pharmacological inhibition of neuropeptide Y receptors Y1 and Y5 reduces hypoxic breast cancer migration, proliferation, and signaling., PMID:37264315
Design of Novel Imidazopyrazine Derivative against Breast Cancer via Targeted NPY1R Antagonist., PMID:37151057
[Effect of Ganmai Dazao Decoction on ethology of rats with PTSD and its mechanism]., PMID:36872240
Neuropeptide Y protects kidney from acute kidney injury by inactivating M1 macrophages via the Y1R-NF-κB-Mincle-dependent mechanism., PMID:36632461
Spinal neuropeptide Y Y1 receptor-expressing neurons are a pharmacotherapeutic target for the alleviation of neuropathic pain., PMID:36343228
Integrative Analysis of Exosomal miR-452 and miR-4713 Downregulating NPY1R for the Prevention of Childhood Obesity., PMID:35401881
Structural basis of neuropeptide Y signaling through Y1 receptor., PMID:35165283
NPY1R exerts inhibitory action on estradiol-stimulated growth and predicts endocrine sensitivity and better survival in ER-positive breast cancer., PMID:35121782
Expression of hypoxia inducible factor-dependent neuropeptide Y receptors Y1 and Y5 sensitizes hypoxic cells to NPY stimulation., PMID:35093384
Neuropeptide Y1 receptor antagonism protects β-cells and improves glycemic control in type 2 diabetes., PMID:34890851
Restraint stress potentiates neuropeptide Y-mediated impairment on spatial memory in rats., PMID:34871704
Corrigendum to: Intracolonic Neuropeptide Y Y1 Receptor Inhibition Attenuates Intestinal Inflammation in Murine Colitis and Cytokine Release in IBD Biopsies., PMID:34792116
Differential regulation of NPY and SP receptor expression in STRO-1+ve PDLSCs by inflammatory cytokines., PMID:34773642
The Neuropeptide Y1 Receptor Ligand-Modified Cell Membrane Promotes Targeted Photodynamic Therapy of Zeolitic Imidazolate Frameworks for Breast Cancer., PMID:34767373
Intracolonic Neuropeptide Y Y1 Receptor Inhibition Attenuates Intestinal Inflammation in Murine Colitis and Cytokine Release in IBD Biopsies., PMID:34613372
Conditional Inactivation of Limbic Neuropeptide Y-1 Receptors Increases Vulnerability to Diet-Induced Obesity in Male Mice., PMID:34445453
Effects of Nifedipine on Renal and Cardiovascular Responses to Neuropeptide Y in Anesthetized Rats., PMID:34361613
Neuropeptide Y suppresses thermogenic and cardiovascular sympathetic nerve activity via Y1 receptors in the paraventricular nucleus and dorsomedial hypothalamus., PMID:34235800
Peripheral-specific Y1 receptor antagonism increases thermogenesis and protects against diet-induced obesity., PMID:33976180
Theoretical study of the interactions between peptide tyrosine tyrosine [PYY (1-36)], a newly identified modulator in type 2 diabetes pathophysiology, with receptors NPY1R and NPY4R., PMID:33782920
Fast A-type currents shape a rapidly adapting form of delayed short latency firing of excitatory superficial dorsal horn neurons that express the neuropeptide Y Y1 receptor., PMID:33768539
Budded baculoviruses as a receptor display system to quantify ligand binding with TIRF microscopy., PMID:33464268
Neuropeptide Y mediates cardiac hypertrophy through microRNA-216b/FoxO4 signaling pathway., PMID:33390770
Role of Zip1 in the regulation of NPY expression by MLT to promote fracture healing in rats., PMID:33334091
NPY-Y1 receptor signaling controls spatial learning and perineuronal net expression., PMID:33285203
Neuropeptide Y facilitates P2X1 receptor-dependent vasoconstriction via Y1 receptor activation in small mesenteric arteries during sympathetic neurogenic responses., PMID:33181321
Clinical Significance of Immunohistochemical Expression of Neuropeptide Y1 Receptor in Patients With Breast Cancer in Egypt., PMID:33086223
Behavioral state coding by molecularly defined paraventricular hypothalamic cell type ensembles., PMID:33060330
Galanin and neuropeptide Y interactions elicit antidepressant activity linked to neuronal precursor cells of the dentate gyrus in the ventral hippocampus., PMID:33044017
NPY stimulates cholesterol synthesis acutely by activating the SREBP2-HMGCR pathway through the Y1 and Y5 receptors in murine hepatocytes., PMID:32976883
Targeting spinal neuropeptide Y1 receptor-expressing interneurons to alleviate chronic pain and itch., PMID:32777329
Further evidence for the association of GAL, GALR1 and NPY1R variants with opioid dependence., PMID:32757697
Conditional inactivation of Npy1r gene in mice induces sex-related differences of metabolic and behavioral functions., PMID:32755609
For research use only. Not for human or drug use.
