Catalog No.
YHD65701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp398-Leu640
Predicted molecular weight
55.13 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P25098
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
G-protein coupled receptor kinase 2, GRK2, ADRBK1, Beta-adrenergic receptor kinase 1, BARK1, BARK, Beta-ARK-1
The GRK2/AP-1 Signaling Axis Mediates Vascular Endothelial Dysfunction and Atherosclerosis Induced by Oscillatory Low Shear Stress., PMID:40492401
GPCR kinases phosphorylate GPCR C-terminal peptides in a hierarchical manner., PMID:40490497
GRK2 activates TRAF2-NF-κB signalling to promote hyperproliferation of fibroblast-like synoviocytes in rheumatoid arthritis., PMID:40486864
GRK2-mediated phosphorylation and de-succinylation of PKM2 reduce macrophage glycolysis in rheumatoid arthritis., PMID:40425786
Effect of phosphorylation barcodes on arrestin binding to a chemokine receptor., PMID:40399676
Potent, Selective, and Drug-like G Protein-coupled Receptor Kinase 5 and 6 Inhibitors: Design, Synthesis, and X-ray Structural Studies., PMID:40388590
β-Arrestin mediates the export of ciliary GPR161 but not Smoothened together with the BBSome and IFT machinery., PMID:40384633
Isoprenaline shows unique kinase dependencies in stimulating β1AR-β-arrestin2 interaction compared to endogenous catecholamines., PMID:40354729
MCTR1 ameliorates LPS-induced lung injury by inhibiting neutrophil reverse transendothelial migration., PMID:40339497
GRK2-facilitated TLR4 signaling promotes cardiac fibrosis in rheumatic mice., PMID:40339495
A nanoluciferase complementation-based assay for monitoring β-arrestin2 recruitment to the dopamine D3 receptor., PMID:40290808
Protein Kinases as Mediators for miRNA Modulation of Neuropathic Pain., PMID:40277902
Esaxerenone Improves Vascular Endothelial Dysfunction by Reducing Serum and Glucocorticoid-Regulated Kinase 1 Activity and Enhancing the Akt Pathway in Type 2 Diabetic Mice., PMID:40268465
The intersection of GRK2 and PGE2 in rheumatoid arthritis: a comprehensive update on pathophysiology and treatment., PMID:40261352
Mdm2-Mediated Ubiquitination Plays a Pivotal Role in Differentiating the Endocytic Roles of GRK2 and Arrestin3., PMID:40244017
Smoothened inhibition of PKA at cilia transduces Hedgehog signals., PMID:40235996
Unveiling the Role of GRK2: From Immune Regulation to Cancer Therapeutics., PMID:40224487
Therapeutic Efficacy of a Novel Pharmacologic GRK2 Inhibitor in Multiple Animal Models of Heart Failure., PMID:40131155
The guanine nucleotide exchange factor Ric-8A regulates the sensitivity of constitutively active Gαq to the inhibitor YM-254890., PMID:40118458
GRK2 and Mitochondrial Dynamics in Cardiovascular Health and Disease., PMID:40076919
Cardioprotective effect of genetic ablation of the G-protein-coupled receptor kinase GRK2 in adult pancreatic β-cells during high-fat diet., PMID:40054692
Paeoniflorin-6'-O-benzene sulfonate inhibits keratinocyte proliferation by restoring GRK2-JAK1 colocalization in mouse model of psoriasis., PMID:40037425
Inhibition of GRK2-PDE4D Axis Suppresses Fibroblast-Like Synoviocytes Hyperplasia and Alleviates Experimental Arthritis., PMID:39990667
G-protein coupled receptor kinase-2 regulates the migration of chronic lymphocytic leukaemia cells to sphingosine-1 phosphate in vitro and their trafficking in vivo., PMID:39988601
Canonical or non-canonical, all aspects of G protein-coupled receptor kinase 2 in heart failure., PMID:39960030
Rpl13a snoRNAs-regulated NADPH oxidase 1-dependent ROS generation: A novel RBC pathway mediating complement C3a deposition and triggering thrombosis in aging and venous blood clotting disorders., PMID:39938620
Novel role of GRK2 in isoprenaline-induced activation of Na+/H+ exchanger 3 independent of β2-adrenergic receptor signaling., PMID:39932653
Role of the G protein-coupled receptor kinase 2/3 N terminus in discriminating the endocytic effects of opioid agonist drugs., PMID:39919161
Inhibition of GRK2 reduced doxorubicin-induced oxidative stress and apoptosis through upregulating ADH1., PMID:39914624
Icariin improves erectile function in spontaneously hypertensive rats by downregulating GRK2 in penile cavernous tissue., PMID:39905744
Heart-derived factors and organ cross-talk in settings of health and disease: new knowledge and clinical opportunities for multimorbidity., PMID:39888058
Activation of APJ Receptors by CMF-019, But Not Apelin, Causes Endothelium-Dependent Relaxation of Spontaneously Hypertensive Rat Coronary Arteries., PMID:39836102
Proximity based proteomics reveals Git1 as a regulator of Smoothened signaling., PMID:39829937
The selective serotonin reuptake inhibitor paroxetine improves right ventricular systolic function in experimental pulmonary hypertension., PMID:39802918
CBD and the 5-HT1A receptor: A medicinal and pharmacological review., PMID:39778776
Klotho enhances stability of chronic kidney disease atherosclerotic plaques by inhibiting GRK2/PLC-β-mediated endoplasmic reticulum stress in macrophages via modulation of the ROS/SHP1 pathway., PMID:39738381
Potential cardioprotective effect of paroxetine against ventricular remodeling in an animal model of myocardial infarction: a comparative study., PMID:39696491
Signal profiles and spatial regulation of β-arrestin recruitment through Gβ5 and GRK3 at the μ-opioid receptor., PMID:39579957
Design, synthesis, and X-ray structural studies of a series of highly potent, selective, and drug-like G protein-coupled receptor kinase 5 inhibitors., PMID:39549325
GRK2 mediates cisplatin-induced acute liver injury via the modulation of NOX4., PMID:39546067
GRK2 Protein Mediates the ANRIL, a lncRNA, to Affect the Proliferation and Apoptosis of Kasumi-1 Cells., PMID:39473411
Transactivation of the EGF receptor as a novel desensitization mechanism for G protein-coupled receptors, illustrated by dopamine D2-like and β2 adrenergic receptors., PMID:39468452
Female Specific Restrictive Cardiomyopathy and Metabolic Dysregulation in transgenic mice expressing a Peptide of the Amino-Terminus of GRK2., PMID:39463972
The roles of G protein-coupled receptor kinase 2 in renal diseases., PMID:39438268
The Ubiquitination of Arrestin3 within the Nucleus Triggers the Nuclear Export of Mdm2, Which, in Turn, Mediates the Ubiquitination of GRK2 in the Cytosol., PMID:39273591
G-Protein-Coupled Receptor Kinase 2 Inhibition Induces Meiotic Arrest by Disturbing Ca2+ Release in Porcine Oocytes., PMID:39262106
GRK2-mediated AKT activation controls cell cycle progression and G2 checkpoint in a p53-dependent manner., PMID:39198399
Unveiling the intracellular dynamics of α4β2 nAChR-mediated ERK activation through the interplay of arrestin, Gβγ, and PKCβII., PMID:39163903
N-demethylsinomenine metabolite and its prototype sinomenine activate mast cells via MRGPRX2 and aggravate anaphylaxis., PMID:39144634
GRK2 kinases in the primary cilium initiate SMOOTHENED-PKA signaling in the Hedgehog cascade., PMID:39138140
For research use only. Not for human or drug use.
