Catalog No.
YHD61601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ile28-Arg249
Predicted molecular weight
51.24 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P24158
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PR3, PR-3, AGP7, Leukocyte proteinase 3, C-ANCA antigen, NP-4, Wegener autoantigen, P29, MBN, PRTN3, Myeloblastin, Neutrophil proteinase 4
Identification and validation of diagnostic markers and drugs for pediatric bronchopulmonary dysplasia based on integrating bioinformatics and molecular docking analysis., PMID:40333951
CRISPR-Cas9 mediated proteinase 3 autoantigen deletion as a treatment strategy for anti-neutrophil cytoplasmic autoantibody-associated vasculitis., PMID:40268165
Low expression of PRTN3 regulates the progression of gastric cancer by inhibition of cell cycle and promotion of apoptosis., PMID:40104702
Proteomic analysis of carotid artery plaques with and without vulnerable features on magnetic resonance angiography with vessel wall imaging: a pilot study., PMID:40034248
Plasma anti-PRTN3 IgG and IgM autoantibodies: novel biomarkers for early detection of lung adenocarcinoma., PMID:40028338
PRTN3 promotes IL33/Treg-mediated tumor immunosuppression by enhancing the M2 polarization of tumor-associated macrophages in lung adenocarcinoma., PMID:39993649
Meta-Analysis and DIA-MS-Based Proteomic Investigation of COPD Patients and Asymptomatic Smokers in the Indian Population., PMID:39436829
Identification of Blood Biomarkers in Ischemic Stroke by Integrated Analysis of Metabolomics and Proteomics., PMID:39167481
Proteinase 3 depletion attenuates leukemia by promoting myeloid differentiation., PMID:38589495
Critical roles of S100A12, MMP9, and PRTN3 in sepsis diagnosis: Insights from multiple microarray data analyses., PMID:38447501
Blood gene expression biomarkers of response to anti-TNF drugs in pediatric inflammatory bowel diseases before initiation of treatment., PMID:38401525
Immunoregulatory and neutrophil-like monocyte subsets with distinct single-cell transcriptomic signatures emerge following brain injury., PMID:38310257
High serum proteinase-3 levels predict poor progression-free survival and lower efficacy of bevacizumab in metastatic colorectal cancer., PMID:38308214
Stabilizing the Proteomes of Acute Myeloid Leukemia Cells: Implications for Cancer Proteomics., PMID:38219859
Effect of Metformin on Plasma and Cerebrospinal Fluid Biomarkers in Non-Diabetic Older Adults with Mild Cognitive Impairment Related to Alzheimer's Disease., PMID:38160357
Panton-Valentine leukocidin-induced neutrophil extracellular traps lack antimicrobial activity and are readily induced in patients with recurrent PVL + -Staphylococcus aureus infections., PMID:37943843
Cerebrospinal fluid proteomics in meningitis patients with reactivated varicella zoster virus., PMID:37904697
Comparative analysis of peripheral blood immunoinflammatory landscapes in patients with acute cholangitis and its secondary septic shock using single-cell RNA sequencing., PMID:37864923
A novel multi-ancestry proteome-wide Mendelian randomization study implicates extracellular proteins, tubular cells, and fibroblasts in estimated glomerular filtration rate regulation., PMID:37774922
mRNA expression profile reveals differentially expressed genes in splenocytes of experimental autoimmune encephalomyelitis model., PMID:37427716
Integrated proteogenomic characterization reveals an imbalanced hepatocellular carcinoma microenvironment after incomplete radiofrequency ablation., PMID:37231509
Risk of relapse of ANCA-associated vasculitis among patients homozygous for the proteinase 3 gene Val119Ile polymorphism., PMID:36990659
Fusobacterium nucleatum promotes the early occurrence of esophageal cancer through upregulation of IL-32/PRTN3 expression., PMID:36919771
Identification of PRTN3 as a novel biomarker for the diagnosis of early gastric cance., PMID:36804624
A Novel Prognostic Pyroptosis-Related Gene Signature Correlates to Oxidative Stress and Immune-Related Features in Gliomas., PMID:36778205
Quantitative tissue proteome profile reveals neutrophil degranulation and remodeling of extracellular matrix proteins in early stage gallbladder cancer., PMID:36686780
Specific Blood RNA Profiles in Individuals with Acute Spinal Cord Injury as Compared with Trauma Controls., PMID:36686379
PRTN3 variant correlates with increased autoantigen levels and relapse risk in PR3-ANCA versus MPO-ANCA disease., PMID:36626226
Novel plasma protein biomarkers from critically ill sepsis patients., PMID:36572854
Relevant proteins for the monitoring of engraftment phases after allogeneic hematopoietic stem cell transplantation., PMID:36403426
The amniotic fluid proteome predicts imminent preterm delivery in asymptomatic women with a short cervix., PMID:35821507
Meta-analysis confirmed genetic susceptibility conferred by multiple risk variants from CTLA4 and SERPINA1 in granulomatosis with polyangiitis., PMID:35656856
Meningitic Escherichia coli-Induced Interleukin-17A Facilitates Blood-Brain Barrier Disruption via Inhibiting Proteinase 3/Protease-Activated Receptor 2 Axis., PMID:35221923
Bioinformatics analysis and identification of hub genes and immune-related molecular mechanisms in chronic myeloid leukemia., PMID:35111390
Proteomic profiling reveals a distinctive molecular signature for critically ill COVID-19 patients compared with asthma and chronic obstructive pulmonary disease., PMID:35017110
Myeloperoxidase and Other Markers of Neutrophil Activation Associate With Malaria and Malaria/HIV Coinfection in the Human Placenta., PMID:34737733
Enhanced Expression of Autoantigens During SARS-CoV-2 Viral Infection., PMID:34276672
Mapping Salivary Proteases in Sjögren's Syndrome Patients Reveals Overexpression of Dipeptidyl Peptidase-4/CD26., PMID:34220840
Reduced neutrophil granular proteins and post-treatment modulation in tuberculous lymphadenitis., PMID:34153068
Detecting Periprosthetic Joint Infection by Using Mass Spectrometry., PMID:34097653
Repression of CTSG, ELANE and PRTN3-mediated histone H3 proteolytic cleavage promotes monocyte-to-macrophage differentiation., PMID:34017121
Advances in the genomics of ANCA-associated vasculitis-a view from East Asia., PMID:33686257
Inflammatory Proteins HMGA2 and PRTN3 as Drivers of Vulvar Squamous Cell Carcinoma Progression., PMID:33374674
Proteins associated with neutrophil degranulation are upregulated in nasopharyngeal swabs from SARS-CoV-2 patients., PMID:33079950
Dietary Erythrodiol Modifies Hepatic Transcriptome in Mice in a Sex and Dose-Dependent Way., PMID:33020388
Time Series Gene Expression Profiles Analysis Identified Several Potential Biomarkers for Sepsis., PMID:32845709
Multidimensional study of the heterogeneity of leukemia cells in t(8;21) acute myelogenous leukemia identifies the subtype with poor outcome., PMID:32747558
Activity-based protein profiling guided identification of urine proteinase 3 activity in subclinical rejection after renal transplantation., PMID:32549867
ANCA autoantigen gene expression highlights neutrophil heterogeneity where expression in normal-density neutrophils correlates with ANCA-induced activation., PMID:32446935
Lack of Proteinase 3 Stabilizes Advanced Atherosclerotic Lesions., PMID:32403136
For research use only. Not for human or drug use.
