Catalog No.
YHD54801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly55-Gln422
Predicted molecular weight
44.38 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P22830
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Ferrochelatase, mitochondrial, FECH, Heme synthase, Protoheme ferro-lyase
KDM4C works in concert with GATA1 to regulate heme metabolism in head and neck squamous cell carcinoma., PMID:40259045
Modeling the Interactions Between Chemicals and Proteins to Predict the Health Consequences of Air Pollution., PMID:40238577
Regulation of the expression of ferrochelatase in a murine model of diabetes mellitus type I., PMID:40230493
Increased Mitochondrial Superoxide Level Is Partially Associated With Vemurafenib-Induced Renal Tubular Toxicity., PMID:40018909
CgPPOX and CgFECH Mediate Protoporphyrin IX Accumulation Predominantly in the Outer Mantle Fold of Pacific Oyster Crassostrea gigas., PMID:39937285
The Histamine Pathway is a Target to Treat Hepatic Experimental Erythropoietic Protoporphyria., PMID:39824305
Chondroprotective Effect of Campylaephora hypnaeoides Extract in Primary Chondrocytes and Rat OA Model., PMID:39769155
TCONS_00025035-miR-101-UROS is potentially involved in the regulation of heme synthesis pathway and influences mantle melanin deposition by targeting porphyrin in Manila clam (Ruditapes philippinarum)., PMID:39461636
CRISPR/Cas9-Mediated fech Knockout Zebrafish: Unraveling the Pathogenesis of Erythropoietic Protoporphyria and Facilitating Drug Screening., PMID:39409147
Key Genes FECH and ALAS2 under Acute High-Altitude Exposure: A Gene Expression and Network Analysis Based on Expression Profile Data., PMID:39202434
Case report: Xeroderma pigmentosum Group A with erythropoietic protoporphyria in a young Chinese patient., PMID:39129919
Exploring the Antiangiogenic and Anti-Inflammatory Potential of Homoisoflavonoids: Target Identification Using Biotin Probes., PMID:39062499
Impact of Phosphorylation at Various Sites on the Active Pocket of Human Ferrochelatase: Insights from Molecular Dynamics Simulations., PMID:38928065
Potential therapeutic efficacy of photodynamic therapy on female hormonal-dependent cancers in a hormonal simulated microenvironment., PMID:38316340
Exploring Thiazolopyridine AV25R: Unraveling of Biological Activities, Selective Anti-Cancer Properties and In Silico Target and Binding Prediction in Hematological Neoplasms., PMID:38138609
Identification of common genes and pathways underlying imatinib and nilotinib treatment in CML: a Bioinformatics Study., PMID:38117080
Congenital asplenia impairs heme-iron recycling during erythropoiesis in zebrafish., PMID:38040044
Harnessing large language models (LLMs) for candidate gene prioritization and selection., PMID:37845713
Knockdown of SETD2 promotes erastin-induced ferroptosis in ccRCC., PMID:37604811
A role of splenic heme biosynthesis pathway in the persistent prophylactic actions of arketamine in lipopolysaccharide-treated mice., PMID:37491335
Glutamate dehydrogenase combined with ferrochelatase as a biomarker of liver injury induced by antituberculosis drugs., PMID:37259680
Heme biosensor-guided in vivo pathway optimization and directed evolution for efficient biosynthesis of heme., PMID:36859288
Proteomic Analysis of Ferrochelatase Interactome in Erythroid and Non-Erythroid Cells., PMID:36836934
Protoporphyrin IX (PpIX) Fluorescence during Meningioma Surgery: Correlations with Histological Findings and Expression of Heme Pathway Molecules., PMID:36612300
A pilot study of oral iron therapy in erythropoietic protoporphyria and X-linked protoporphyria., PMID:36406817
Exposure to a mixture of per-and polyfluoroalkyl substances modulates pulmonary expression of ACE2 and circulating hormones and cytokines., PMID:36270329
FECH Expression Correlates with the Prognosis and Tumor Immune Microenvironment in Clear Cell Renal Cell Carcinoma., PMID:36059798
18F-Fluoroethylcholine PET/CT Radiomic Analysis for Newly Diagnosed Prostate Cancer Patients: A Monocentric Study., PMID:36012384
Endothelin-1 depletion of cartilage oligomeric matrix protein modulates pulmonary artery superoxide and iron metabolism-associated mitochondrial heme biosynthesis., PMID:35943724
Flavonoid 4,4'-dimethoxychalcone induced ferroptosis in cancer cells by synergistically activating Keap1/Nrf2/HMOX1 pathway and inhibiting FECH., PMID:35697292
Heme Biosynthesis Factors and 5-ALA Induced Fluorescence: Analysis of mRNA and Protein Expression in Fluorescing and Non-fluorescing Gliomas., PMID:35665365
Chemical Proteomics Reveals Off-Targets of the Anandamide Reuptake Inhibitor WOBE437., PMID:35482948
The role of the genetic variant FECH rs11660001 in the occurrence of anti-tuberculosis drug-induced liver injury., PMID:35470464
Inhibition of ABCG2 transporter by lapatinib enhances 5-aminolevulinic acid-mediated protoporphyrin IX fluorescence and photodynamic therapy response in human glioma cell lines., PMID:35390338
CGN Correlates With the Prognosis and Tumor Immune Microenvironment in Clear Cell Renal Cell Carcinoma., PMID:35223987
Analysis of corticosteroid and antiepileptic drug treatment effects on heme biosynthesis mRNA expression in lower-grade gliomas: Potential implications for 5-ALA metabolization., PMID:35149260
Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles., PMID:35115687
Methods to Measure the Inhibition of ABCG2 Transporter and Ferrochelatase Activity to Enhance Aminolevulinic Acid-Protoporphyrin IX Fluorescence-Guided Tumor Detection and Resection., PMID:35094360
Small-molecule inhibitors of ferrochelatase are antiangiogenic agents., PMID:35090600
Analysis of Factors Affecting 5-ALA Fluorescence Intensity in Visualizing Glial Tumor Cells-Literature Review., PMID:35055109
Iron, Heme Synthesis and Erythropoietic Porphyrias: A Complex Interplay., PMID:34940556
Complex response to physiological and drug-induced hepatic heme demand in monoallelic ALAS1 mice., PMID:34900592
Identification of four hub genes in venous thromboembolism via weighted gene coexpression network analysis., PMID:34861826
Liver involvement in patients with erythropoietic protoporphyria: retrospective analysis of clinicopathological features of 5 cases., PMID:34844099
Insights Into mRNA and Long Non-coding RNA Profiling RNA Sequencing in Uterus of Chickens With Pink and Blue Eggshell Colors., PMID:34692811
Nkx3-1 and Fech genes might be switch genes involved in pituitary non-functioning adenoma invasiveness., PMID:34686726
Tracking immature reticulocyte proteins for improved detection of recombinant human erythropoietin (rhEPO) abuse., PMID:34626008
Cockayne syndrome group A and ferrochelatase finely tune ribosomal gene transcription and its response to UV irradiation., PMID:34581821
Alleviation of norflurazon-induced photobleaching by overexpression of Fe-chelatase in transgenic rice., PMID:34566459
Insight into the function of active site residues in the catalytic mechanism of human ferrochelatase., PMID:34402499
For research use only. Not for human or drug use.
