Catalog No.
YHD53601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser558-Gly816
Predicted molecular weight
54.68 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P22681
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CBL, RING finger protein 55, Proto-oncogene c-Cbl, CBL2, E3 ubiquitin-protein ligase CBL, RING-type E3 ubiquitin transferase CBL, Casitas B-lineage lymphoma proto-oncogene, Signal transduction protein CBL, RNF55
Intramuscular Vitamin B12 Treatment in Transcobalamin II Deficiency: Case Series Clinical Outcomes., PMID:40496011
CBL-mediated AQP1 ubiquitination aggravates kidney-yang deficiency syndrome by promoting lipid metabolism dysregulation., PMID:40481542
ANXA1 binds and stabilizes EGFR to promote nasopharyngeal carcinoma radioresistance., PMID:40470752
Long-term outcome of CblC deficiency complicated with pulmonary hypertension., PMID:40468431
Calcium-responsive phosphorylation of SlLHP1b epigenetically suppresses auxin synthesis to control drought-induced flower drop in tomato., PMID:40460834
Cbl-b inhibitor NX-1607 activates MAPK/ERK signaling pathway and enhances T-cell activation., PMID:40447319
Missense mutations in MMACHC protein from cblC disease affect its conformational stability and vitamin B12-binding activity: The example of R161Q mutation., PMID:40441036
SERCA activation prevents Ca2+ and ATP upregulation during 3-day soleus muscle unloading in rats., PMID:40433945
Transcriptome Analysis Reveals the Molecular Mechanisms for Mycorrhiza-Enhanced Drought Tolerance in Maize by Regulating the Ca2+ Signaling Pathway., PMID:40422709
Nodal Mature Plasmacytoid Dendritic Cell Proliferation in a Patient With Chronic Myelomonocytic Leukemia: A Diagnostic Mimic of Blastic Plasmacytoid Dendritic Cell Neoplasm., PMID:40415500
Decoding the calcium signal: Structural insights into CBL-CIPK pathway in plants., PMID:40373939
Overcoming NK-mediated rejection by anti-3rd-party central memory veto CD8 T cells through downregulation of DNAM-1 on alloreactive NK cells., PMID:40343795
Locking CBL TKBD in its native conformation presents a novel therapeutic opportunity in mutant CBL-dependent leukemia., PMID:40329529
Unlocking LAG3: Ubiquitin's unexpected role., PMID:40315815
Contribution of arbuscular mycorrhiza and exoenzymes to nitrogen acquisition of sorghum under drought., PMID:40303862
A novel wheat S1-bZIP gene, TabZIP11-D, confers stress resistance in Arabidopsis., PMID:40300507
Multi-omics reveal the role of nociception-related genes TNXB, CTNND1 and CBL in depression., PMID:40286918
Polydatin reactivates mitochondrial bioenergetics and mitophagy while preventing premature senescence by modulating microRNA-155 and its direct targets in human fibroblasts with trisomy 21., PMID:40280316
circ-0001454 alleviates asthma airway inflammation and remodeling via sponging miR-770-5p and regulating cbl-b., PMID:40264707
CBLB Regulates MAPK-P38 Pathway via MAP3K9 Ubiquitination to Inhibit GBM Cell Invasion and Migration., PMID:40254893
Long-term safety, tolerability, and efficacy of eptinezumab in chronic cluster headache (CHRONICLE): an open-label safety trial., PMID:40252664
Genetic dissection of total protein content, phenolic content and seed quality traits in pigeonpea (Cajanus cajan) using 62K pigeonpea genic SNP chip., PMID:40244494
Association of inflammation and protein carbamylation in patients with COVID-19., PMID:40241896
Mechanistic Study of Chaga Medicinal Mushroom Inonotus obliquus (Agaricomycetes) Phenolic Compounds in the Treatment of Liver Cancer: A Database and Simulation Approach., PMID:40228216
ZmCIPK33 and ZmSnRK2.10 mutually reinforce the abscisic acid signaling pathway for combating drought stress in maize., PMID:40226964
Circular RNA circSTX12 regulates osteo-adipogenic balance and proliferation of BMSCs in senile osteoporosis., PMID:40192802
Extracellular vesicles from adipose-derived mesenchymal stem cells alleviate acute lung injury via the CBL/AMPK signaling pathway., PMID:40165177
Correction to "The Signalling Pathways, Calcineurin B-Like Protein 5 (CBL5)-CBL-Interacting Protein Kinase 8 (CIPK8)/CIPK24-Salt Overly Sensitive 1 (SOS1), Transduce Salt Signals in Seed Germination in Arabidopsis"., PMID:40159673
Ubiquitin Ligases in Control: Regulating NLRP3 Inflammasome Activation., PMID:40152367
Evaluation of the Binding Affinity of Nitrosylcobalamin to Intrinsic Factor as a Predictive Model for Cobalamin Binding Protein Interactions: A Comparative Study with Hydroxocobalamin., PMID:40150986
Anti-Infective Screening of Selected Nine Cannabinoids Against Clostridium perfringens and Influenza A (H5N1) Neuraminidases, and SARS-CoV-2 Main Protease and Spike Protein Interactions., PMID:40136439
Possible Trace of HTLV-1 Virus in Modulation of Cbl-b, ITCH, and PP2A Suppressor Genes., PMID:40123588
Cerebrolysin Induces Dendritic Tree Plastic Changes and BDNF Increase in the Amygdala of Male Rats with Maternal Deprivation., PMID:40123021
Rational design, optimization, and biological evaluation of novel pyrrolo-pyridone derivatives as potent and orally active Cbl-b inhibitors., PMID:40120499
FGR Src family kinase causes signaling and phenotypic shift mimicking retinoic acid-induced differentiation of leukemic cells., PMID:40116400
Ras-MAPK pathway in patients with lupus nephritis., PMID:40102014
Ligand-induced ubiquitination unleashes LAG3 immune checkpoint function by hindering membrane sequestration of signaling motifs., PMID:40101708
Hierarchical Regulatory Networks Reveal Conserved Drivers of Plant Drought Response at the Cell-Type Level., PMID:40091436
Clinical and radiographic peri-implant parameters in type-2 diabetic and non-diabetic individuals with major depressive disorder., PMID:40089622
Identification of key LncRNAs and mRNAs associated with intramuscular fat in pig via WGCNA., PMID:40069611
Germline mutation in Cbl proto-oncogene B is associated with inherited thrombocytopenia and predisposes megakaryocytes to ferroptosis., PMID:40044065
Rapid development of acute monocytic leukemia (AML-M5b) with t(9;11)(p22;q23) after chemotherapy for T-cell lymphoblastic lymphoma: A case report., PMID:40040976
Genome-wide analysis of CBL and CIPK gene families in bermudagrass reveals the CdCIPK29-A1 as a stem growth angle regulator., PMID:40032687
Accordance between weight-based and calculated blood loss for obstetric hemorrhage: a pre-study to a randomized controlled trial., PMID:40024629
Clinical management of three JMML siblings with germline CBL variation., PMID:40020528
Polymersome-mediated Cbl-b silencing activates T cells against solid tumors., PMID:40017436
Plasma membrane-associated calcium signaling modulates zinc homeostasis in Arabidopsis., PMID:39979205
Asparagine drives immune evasion in bladder cancer via RIG-I stability and type I IFN signaling., PMID:39964752
Nuclear envelope and chromatin choreography direct cellular differentiation., PMID:39943681
Phenotype puzzle: the role of novel LMBRD1 gene variant in Cbl deficiency causing Dyskeratosis Congenita-like clinical manifestations., PMID:39939801
For research use only. Not for human or drug use.
