Catalog No.
RHJ81601
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:4000-1:8000
Target
ADAMTS5, ADAM-TS 5, ADAM-TS5, ADAMTS-5, ADAMTS11, ADAM-TS 11, ADAMTS-11, ADMP2, ADMP-2, A disintegrin and metalloproteinase with thrombospondin motifs 5, A disintegrin and metalloproteinase with thrombospondin motifs 11, Aggrecanase-2
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q9UNA0
Applications
ELISA, Neutralization
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
12F4
Stabilisation of extracellular matrix is crucial to rapamycin-mediated life span increase in Marfan mgR/mgR mice., PMID:40021021
Translational pharmacokinetic and pharmacodynamic modelling of the anti-ADAMTS-5 NANOBODY® (M6495) using the neo-epitope ARGS as a biomarker., PMID:39704923
Exploring Intra-Articular Administration of Monoclonal Antibodies as a Novel Approach to Osteoarthritis Treatment: A Systematic Review., PMID:39457530
Syndecan-4 inhibition attenuates cartilage degeneration in temporomandibular joint osteoarthritis., PMID:39101668
Autoreactivity to self-antigens LL37 and ADAMTSL5 influences the clinical response to risankizumab in psoriatic patients., PMID:38797050
Combined genetic-pharmacologic inactivation of tightly linked ADAMTS proteases in temporally specific windows uncovers distinct roles for versican proteolysis and glypican-6 in cardiac development., PMID:38750698
Inhibition of HMGB1 suppresses inflammation and catabolism in temporomandibular joint osteoarthritis <em>via</em> NF-κB signaling pathway., PMID:35726537
Mechanical Stimulation Protects Against Chondrocyte Pyroptosis Through Irisin-Induced Suppression of PI3K/Akt/NF-κB Signal Pathway in Osteoarthritis., PMID:35356271
Overload of the Temporomandibular Joints Accumulates γδ T Cells in a Mouse Model of Rheumatoid Arthritis: A Morphological and Histological Evaluation., PMID:35069529
ADAMTS5 in Osteoarthritis: Biological Functions, Regulatory Network, and Potential Targeting Therapies., PMID:34434966
Maltol prevents the progression of osteoarthritis by targeting PI3K/Akt/NF-κB pathway: In vitro and in vivo studies., PMID:33211383
The Anti-ADAMTS-5 Nanobody® M6495 Protects Cartilage Degradation Ex Vivo., PMID:32825512
Erratum: Treatment of Dystrophic mdx Mice with an ADAMTS-5 Specific Monoclonal Antibody Increases the Ex Vivo Strength of Isolated Fast Twitch Hindlimb Muscles. Biomolecules 2020, 10, 416., PMID:32679807
Treatment of Dystrophic mdx Mice with an ADAMTS-5 Specific Monoclonal Antibody Increases the Ex Vivo Strength of Isolated Fast Twitch Hindlimb Muscles., PMID:32156081
The protective effect of Ellagic acid (EA) in osteoarthritis: An in vitro and in vivo study., PMID:32058211
The protective effects of dulaglutide against advanced glycation end products (AGEs)-induced degradation of type Ⅱ collagen and aggrecan in human SW1353 chondrocytes., PMID:32004530
Inflammation and joint destruction may be linked to the generation of cartilage metabolites of ADAMTS-5 through activation of toll-like receptors., PMID:31734268
The "elusive DMOAD": Aggrecanase inhibition from laboratory to clinic., PMID:31621572
ANGPTL2 Promotes Inflammation via Integrin α5β1 in Chondrocytes., PMID:31581797
Analysis of Aggrecanase Activity Using Neoepitope Antibodies., PMID:31463908
Adamts5-/- Mice Exhibit Altered Aggrecan Proteolytic Profiles That Correlate With Ascending Aortic Anomalies., PMID:31366218
Inhibition of MMPs and ADAM/ADAMTS., PMID:30826330
Catabolism of Fibromodulin in Developmental Rudiment and Pathologic Articular Cartilage Demonstrates Novel Roles for MMP-13 and ADAMTS-4 in C-terminal Processing of SLRPs., PMID:30700002
FGF23 Regulates Wnt/β-Catenin Signaling-Mediated Osteoarthritis in Mice Overexpressing High-Molecular-Weight FGF2., PMID:29718273
Massive aggrecan and versican accumulation in thoracic aortic aneurysm and dissection., PMID:29515038
The extracellular matrix-degrading protein ADAMTS5 is expressed in the nuclei of urothelial cells in healthy rats., PMID:29334289
Hemoglobin stimulates the expression of ADAMTS-5 and ADAMTS-9 by synovial cells: a possible cause of articular cartilage damage after intra-articular hemorrhage., PMID:29137610
Matriptase Induction of Metalloproteinase-Dependent Aggrecanolysis In Vitro and In Vivo: Promotion of Osteoarthritic Cartilage Damage by Multiple Mechanisms., PMID:28464560
Development of a monoclonal anti-ADAMTS-5 antibody that specifically blocks the interaction with LRP1., PMID:28306378
Inhibition of Shedding of Low-Density Lipoprotein Receptor-Related Protein 1 Reverses Cartilage Matrix Degradation in Osteoarthritis., PMID:28235248
Systemic inhibition of IL-6/Stat3 signalling protects against experimental osteoarthritis., PMID:27789465
Interleukin-1α induces focal degradation of biglycan and tissue degeneration in an in-vitro ovine meniscal model., PMID:27615609
E2 regulates MMP-13 via targeting miR-140 in IL-1β-induced extracellular matrix degradation in human chondrocytes., PMID:27165343
The Investigation of a Disintegrin and Metalloproteinase with ThromboSpondin Motifs (ADAMTS) 1, 5 and 16 in Thoracic Aortic Aneurysms and Dissections., PMID:27156333
Overexpression of ADAMTS5 can regulate the migration and invasion of non-small cell lung cancer., PMID:26738863
Anti-ADAMTS5 monoclonal antibodies: implications for aggrecanase inhibition in osteoarthritis., PMID:26657033
Development of human neutralizing antibody to ADAMTS4 (aggrecanase-1) and ADAMTS5 (aggrecanase-2)., PMID:26612259
Therapeutic effects of an anti-ADAMTS-5 antibody on joint damage and mechanical allodynia in a murine model of osteoarthritis., PMID:26410555
Antibody-based exosite inhibitors of ADAMTS-5 (aggrecanase-2)., PMID:26303525
Carnosol Inhibits Pro-Inflammatory and Catabolic Mediators of Cartilage Breakdown in Human Osteoarthritic Chondrocytes and Mediates Cross-Talk between Subchondral Bone Osteoblasts and Chondrocytes., PMID:26292290
ADAMTS-5 takes centre stage in new developments for aggrecanase inhibitors., PMID:26028137
The effect of protease inhibitors on the induction of osteoarthritis-related biomarkers in bovine full-depth cartilage explants., PMID:25909781
Translational development of an ADAMTS-5 antibody for osteoarthritis disease modification., PMID:25800415
Interleukin-1 Acts via the JNK-2 Signaling Pathway to Induce Aggrecan Degradation by Human Chondrocytes., PMID:25776267
ADAMTS-4 and ADAMTS-5 expression in human temporomandibular joint discs with internal derangement, correlates with degeneration., PMID:25477257
Determinants of versican-V1 proteoglycan processing by the metalloproteinase ADAMTS5., PMID:25122765
Targeting of ADAMTS5's ancillary domain with the recombinant mAb CRB0017 ameliorates disease progression in a spontaneous murine model of osteoarthritis., PMID:23954517
Extracellular matrix of adipogenically differentiated mesenchymal stem cells reveals a network of collagen filaments, mostly interwoven by hexagonal structural units., PMID:23851162
Pentosan polysulfate: a novel therapy for the mucopolysaccharidoses., PMID:23365668
Dkk-1 promotes angiogenic responses and cartilage matrix proteinase secretion in synovial fibroblasts from osteoarthritic joints., PMID:22736200