Anti-ERN1 Polyclonal Antibody

Catalog No.

PHB21301

Species reactivity

Human, Mouse, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human ERN1 (Phe571-Leu977).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

Endoplasmic reticulum-to-nucleus signaling 1,IRE1a,ERN1,Ire1-alpha,hIRE1p,Serine/threonine-protein kinase/endoribonuclease IRE1,Inositol-requiring protein 1,IRE1

Purification

Purified by antigen affinity column.

Accession

O75460

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

The IRE1α/XBP1 pathway sustains cytokine responses of group 3 innate lymphoid cells in inflammatory bowel disease., PMID:38722686

The inositol-requiring enzyme 1 (IRE1) endoplasmic reticulum stress pathway promotes MDA-MB-231 cell survival and renewal in response to the aryl-ureido fatty acid CTU., PMID:38608921

Tumorous IRE1α facilitates CD8+T cells-dependent anti-tumor immunity and improves immunotherapy efficacy in melanoma., PMID:38291473

Platelets induce endoplasmic reticulum stress in macrophages in vitro., PMID:38278417

Loss of function of XBP1 splicing activity of IRE1α favors B cell tolerance breakdown., PMID:38071801

A CRISPR/Cas9-mediated screen identifies determinants of early plasma cell differentiation., PMID:36685499

Endoplasmic Reticulum Homeostasis Regulates TLR4 Expression and Signaling in Mast Cells., PMID:36233127

Antigen-derived peptides engage the ER stress sensor IRE1α to curb dendritic cell cross-presentation., PMID:35446348

Prostaglandin E2-Induced AKT Activation Regulates the Life Span of Short-Lived Plasma Cells by Attenuating IRE1α Hyperactivation., PMID:35379745

Macrophage-Derived Immunoglobulin M Inhibits Inflammatory Responses via Modulating Endoplasmic Reticulum Stress., PMID:34831038

Targeting the IRE1α/XBP1s pathway suppresses CARM1-expressing ovarian cancer., PMID:34493732

The unfolded protein response and apoptotic regulation in the human placenta due to maternal cigarette smoking and pre-eclampsia., PMID:34492309

Inhibition of IRE1/JNK pathway in HK-2 cells subjected to hypoxia-reoxygenation attenuates mesangial cells-derived extracellular matrix production., PMID:33043579

Understanding the Role of the Unfolded Protein Response Sensor IRE1 in the Biology of Antigen Presenting Cells., PMID:31817075

Endoplasmic Reticulum Stress Markers and Their Possible Implications in Leprosy's Pathogenesis., PMID:30647798

Inhibition of Human Dendritic Cell ER Stress Response Reduces T Cell Alloreactivity Yet Spares Donor Anti-tumor Immunity., PMID:30574153

New Hope for Pancreatic Ductal Adenocarcinoma Treatment Targeting Endoplasmic Reticulum Stress Response: A Systematic Review., PMID:30134550

Inhibition of GRP78 abrogates radioresistance in oropharyngeal carcinoma cells after EGFR inhibition by cetuximab., PMID:29232380

Imiquimod-induced autophagy is regulated by ER stress-mediated PKR activation in cancer cells., PMID:28601430

Lipin-1 regulation of phospholipid synthesis maintains endoplasmic reticulum homeostasis and is critical for triple-negative breast cancer cell survival., PMID:28347999

Molecular signal networks and regulating mechanisms of the unfolded protein response., PMID:28070992

Effects of muscular dystrophy, exercise and blocking activin receptor IIB ligands on the unfolded protein response and oxidative stress., PMID:27554968

Glycyrrhetinic acid induces cytoprotective autophagy via the inositol-requiring enzyme 1α-c-Jun N-terminal kinase cascade in non-small cell lung cancer cells., PMID:26549806

Bevacizumab induces A549 cell apoptosis through the mechanism of endoplasmic reticulum stress in vitro., PMID:26191230

The Endoplasmic Reticulum Stress Sensor Inositol-Requiring Enzyme 1α Augments Bacterial Killing through Sustained Oxidant Production., PMID:26173697

PPARβ/δ Agonist Provides Neuroprotection by Suppression of IRE1α-Caspase-12-Mediated Endoplasmic Reticulum Stress Pathway in the Rotenone Rat Model of Parkinson's Disease., PMID:26160761

Anti-dsDNA antibodies induce inflammation via endoplasmic reticulum stress in human mesangial cells., PMID:26040555

RIPK1 promotes death receptor-independent caspase-8-mediated apoptosis under unresolved ER stress conditions., PMID:25476903

Deficiency of IRE1 and PERK signal pathways in systemic lupus erythematosus., PMID:25226532

High epiregulin expression in human U87 glioma cells relies on IRE1α and promotes autocrine growth through EGF receptor., PMID:24330607

BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α., PMID:22510886

Chikungunya virus-induced autophagy delays caspase-dependent cell death., PMID:22508836

IRE1α disruption causes histological abnormality of exocrine tissues, increase of blood glucose level, and decrease of serum immunoglobulin level., PMID:20885949

Nitric oxide induction of IRE1-alpha-dependent CREB phosphorylation in human glioma cells., PMID:20447464

Phospholipolyzed LDL induces an inflammatory response in endothelial cells through endoplasmic reticulum stress signaling., PMID:20430794

BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha., PMID:19328063

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