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Research Grade Evinacumab

Catalog #:   DHJ88801 Specific References (98) DATASHEET
Host species: Human
Isotype: IgG4-kappa
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DHJ88801

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Human

Isotype

IgG4-kappa

Clonality

Monoclonal

Target

ANG-5, Angiopoietin-like protein 3, ANGPT5, Angiopoietin-5, ANGPTL3, Angiopoietin-related protein 3

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q9Y5C1

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

REGN 1500, CAS: 1446419-85-7

Clone ID

Evinacumab

Data Image
  • SDS-PAGE
    SDS PAGE for Evinacumab
  • Bioactivity
    Detects Human ANGPTL3 in direct ELISAs.
  • SEC-HPLC
    The purity of this product is >95% as determined by SEC-HPLC.
References

Evinacumab for Homozygous Familial Hypercholesterolemia, PMID: 32813947

Evinacumab in Patients with Refractory Hypercholesterolemia, PMID: 33196153

Functional Analysis of LDLR (Low-Density Lipoprotein Receptor) Variants in Patient Lymphocytes to Assess the Effect of Evinacumab in Homozygous Familial Hypercholesterolemia Patients With a Spectrum of LDLR Activity, PMID: 31578082

Will evinacumab become the standard treatment for homozygous familial hypercholesterolemia?, PMID: 33295805

Antibodies to watch in 2020, PMID: 31847708

Evinacumab, PMID: 34292698

Evinacumab: First Approval, PMID: 34003472

Evinacumab-dgnb, PMID: 33881136

Lipid-Lowering Agents, PMID: 30702996

Inhibition of Angiopoietin-Like Protein 3 With a Monoclonal Antibody Reduces Triglycerides in Hypertriglyceridemia, PMID: 31242752

Alirocumab, evinacumab, and atorvastatin triple therapy regresses plaque lesions and improves lesion composition in mice, PMID: 31843957

ANGPTL3 Inhibition in Homozygous Familial Hypercholesterolemia, PMID: 28723334

Cholesterol Lowering Drugs, PMID: 27809434

A randomized study investigating the safety, tolerability, and pharmacokinetics of evinacumab, an ANGPTL3 inhibitor, in healthy Japanese and Caucasian subjects, PMID: 33130482

Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease, PMID: 28538136

Novel emerging therapies in atherosclerosis targeting lipid metabolism, PMID: 32363959

Evinacumab for treatment of familial hypercholesterolemia, PMID: 34253139

Evinacumab for Homozygous Familial Hypercholesterolemia, PMID: 33567206

Evinacumab for Homozygous Familial Hypercholesterolemia, PMID: 33567205

[Evinacumab in patients with treatment-refractory hypercholesterolemia], PMID: 34014366

Evinacumab for Homozygous Familial Hypercholesterolemia, PMID: 33567207

Evinacumab (Evkeeza) for homozygous familial hypercholesterolemia, PMID: 33976097

Evinacumab for Homozygous Familial Hypercholesterolemia. Reply, PMID: 33567208

Targeting apoC-III and ANGPTL3 in the treatment of hypertriglyceridemia, PMID: 32511037

Lipid lowering therapy in cardiovascular disease: From myth to molecular reality, PMID: 32492513

Pharmacological aspects of ANGPTL3 and ANGPTL4 inhibitors: New therapeutic approaches for the treatment of atherogenic dyslipidemia, PMID: 31931117

The efficacy and safety of evinacumab for the treatment of hypercholesterolemia: a meta-analysis, PMID: 34117182

Angiopoietin-Like 3 (ANGPTL3) and Atherosclerosis: Lipid and Non-Lipid Related Effects, PMID: 30011918

Highlights of Studies in Cardiovascular Disease Prevention Presented at the 2020 American College of Cardiology Annual Scientific Session, PMID: 32556778

Volanesorsen in the Treatment of Familial Chylomicronemia Syndrome or Hypertriglyceridaemia: Design, Development and Place in Therapy, PMID: 32753844

[Familial chylomicronemia], PMID: 32841138

Factoring in ANGPTL3 When LDL Is Refractory, PMID: 33296565

Evinacumab Approval Adds a New Option for Homozygous Familial Hypercholesterolemia With a Hefty Price Tag, PMID: 34152800

Bypassing the LDL Receptor in Familial Hypercholesterolemia, PMID: 32813955

A quantitative systems pharmacology modeling platform for evaluating triglyceride profiles in patients with high triglycerides receiving evinacumab, PMID: 34327869

ANGPTL3 Inhibition With Evinacumab Results in Faster Clearance of IDL and LDL apoB in Patients With Homozygous Familial Hypercholesterolemia-Brief Report, PMID: 33691480

Emerging lipid lowering agents targeting LDL cholesterol, PMID: 32243228

Inhibition of Angiopoietin-Like Protein 3 With Evinacumab in Subjects With High and Severe Hypertriglyceridemia, PMID: 34238441

Advances with lipid-lowering drugs for pediatric patients with familial hypercholesterolemia, PMID: 33016816

ANGPTL3 inhibition lowers LDL-C levels in FH, PMID: 32855535

Angiopoietin-Like 3 Protein Inhibition: A New Frontier in Lipid-Lowering Treatment, PMID: 31008773

Homozygous familial hypercholesterolemia: what treatments are on the horizon?, PMID: 32332430

Biotechnology Approaches for the Treatment of Dyslipidemia, PMID: 32519066

Safety and tolerability of injectable lipid-lowering drugs: an update of clinical data, PMID: 31100030

Novel therapies for familial hypercholesterolemia, PMID: 33278127

Evidence for improved survival with treatment of homozygous familial hypercholesterolemia, PMID: 32520777

Angiopoietin-like proteins as therapeutic targets for cardiovascular disease: focus on lipid disorders, PMID: 31856617

Triglyceride-Rich Lipoproteins and Novel Targets for Anti-atherosclerotic Therapy, PMID: 30403015

Marked plaque regression in homozygous familial hypercholesterolemia, PMID: 34004483

Angiopoietin-like proteins inhibitors: New horizons in the treatment of atherogenic dyslipidemia and familial hypercholesterolemia, PMID: 33470417

Long-term experience with lomitapide treatment in patients with homozygous familial hypercholesterolemia: Over 10 years of efficacy and safety data., PMID:40494715

Global disparities in access to lipid-lowering therapies for patients with homozygous familial hypercholesterolemia - A physician survey., PMID:40480942

ANGPTL3: A Breakthrough Target in Treatment for Dyslipidemia and Atherosclerosis., PMID:40467521

Real-World Effectiveness and Safety of Evinacumab in Children and Adults With Homozygous Familial Hypercholesterolemia: A Multisite US Perspective., PMID:40438928

Evinacumab and reduced lipoprotein apheresis in pediatric homozygous familial hypercholesterolemia: a retrospective study on LDL-C., PMID:40393255

Safety and effectiveness of evinacumab in an infant with homozygous familial hypercholesterolemia: A new renaissance for the very young?, PMID:40187919

Evinacumab for Homozygous Familial Hypercholesterolemia: The Italian Cohort of the ELIPSE HoFH Study., PMID:40169529

Beyond LDL: Targeting ANGPTL3 to Reduce Residual Cardiovascular Risk., PMID:40167412

A Case with Oligogenic Familial Hypercholesterolemia Treated by Combination Therapy of Statin, Ezetimibe, PCSK9 Inhibitor, and Lomitapide., PMID:40128994

Comparison of Model-Predicted and Observed Evinacumab Pharmacokinetics and Efficacy in Children Aged < 5 Years With Homozygous Familial Hypercholesterolemia., PMID:40095766

Population Pharmacokinetics and Exposure-Response Modeling for Evinacumab in Children, Adolescents, and Adults With Homozygous Familial Hypercholesterolemia., PMID:40095399

Evinacumab for the treatment of homozygous familial hypercholesterolaemia: first patient case report in Switzerland., PMID:40062884

Treatment With Evinacumab Links a New Pathogenic Variant in the LPL Gene to Persistent Chylomicronemia., PMID:40046103

Effects of Inclisiran, Alirocumab, Evolocumab, and Evinacumab on Lipids: A Network Meta-Analysis., PMID:40026525

Dramatic response to Evinacumab in a North Indian girl with homozygous familial hypercholesterolemia., PMID:40022592

High burden of disease in patients with homozygous familial hypercholesterolemia despite recent advances in therapies and updated guidelines: A real-world study., PMID:39971631

Evinacumab as an adjunct to lipid apheresis in an infant with homozygous familial hypercholesterolemia., PMID:39970166

Emergency Management of Intoxication-Type Inherited Metabolic Disorders., PMID:39953653

Evinacumab for children with homozygous familial hypercholesterolemia: a plain language summary., PMID:39931838

Efficacy of a novel PCSK9 inhibitory peptide alone and with evinacumab in a mouse model of atherosclerosis., PMID:39909173

Molecular Therapeutics in Development to Treat Hyperlipoproteinemia., PMID:39875700

Genetically mimicked effects of evinacumab on psoriasis: a drug target Mendelian randomization study., PMID:39828257

Exploring emerging pharmacotherapies for type 2 diabetes patients with hypertriglyceridemia., PMID:39794291

Homozygous Familial Hypercholesterolemia Treatment: New Developments., PMID:39751968

Homozygous familial hypercholesterolemia in Spain. Data from Registry of the Spanish Atherosclerosis Society., PMID:39514762

Correction to: Evinacumab in homozygous familial hypercholesterolaemia: long-term safety and efficacy., PMID:39302808

Expanding therapeutic options: overview of novel pharmacotherapies for dyslipidemia., PMID:39286934

Drug interactions in cardiology: focus on statins and their combination with other lipid-lowering drugs., PMID:39252198

Advances in targeting LDL cholesterol: PCSK9 inhibitors and beyond., PMID:39070027

Real-world experience of long-term efficacy and safety of evinacumab in patients with homozygous familial hypercholesterolemia treated and untreated with lipoprotein apheresis., PMID:39054196

Circumventing Cardiovascular Calamities: The Dawn of ANGPTL3 Blockade in Severe Dyslipidemia Management., PMID:39039670

Effects of Lipoproteins on Metabolic Health., PMID:38999903

Repurposing lipid-lowering drugs on asthma and lung function: evidence from a genetic association analysis., PMID:38961500

The Long-Term Efficacy and Safety of Evinacumab in Patients With Homozygous Familial Hypercholesterolemia., PMID:38938723

Evinacumab Therapy for Homozygous Familial Hypercholesterolemia: Driving Lipoprotein Clearance Via the Road Less Taken., PMID:38938707

New Insights Into the Treatment of Hyperlipidemia: Pharmacological Updates and Emerging Treatments., PMID:38919858

Decreased LDL-Cholesterol Exposure Following ANGPTL3 Inhibition Reduces Coronary Plaque Development in Homozygous Familial Hypercholesterolemia., PMID:38864785

Evinacumab in homozygous familial hypercholesterolaemia: long-term safety and efficacy., PMID:38856678

ANGPTL3 as a therapeutic target for treating homozygous familial hypercholesterolaemia: a shot in the arm for evinacumab., PMID:38856677

Evinacumab: Mechanism of action, clinical, and translational science., PMID:38845393

Dyslipidaemia management in pregnant patients: a 2024 update., PMID:38784103

Intensive Combination LDL-Lowering Therapy in a Patient With Homozygous Familial Hypercholesterolemia., PMID:38774638

Safety of cardiovascular disease drugs approved between 2014 and 2021 in the US: a pharmacovigilance analysis., PMID:38722712

Evaluating the Effectiveness and Safety of Evinacumab in Treating Hypercholesterolemia and Hypertriglyceridemia: A Systematic Review and Meta-analysis of Randomized Controlled Trials., PMID:38713309

Evinacumab and Cardiovascular Outcome in Patients With Homozygous Familial Hypercholesterolemia., PMID:38695169

How can we improve the prognosis of patients with homozygous familial hypercholesterolemia?, PMID:38658251

Current treatments for the management of homozygous familial hypercholesterolaemia: a systematic review and commentary., PMID:38640433

A machine-learning algorithm using claims data to identify patients with homozygous familial hypercholesterolemia., PMID:38632285

Datasheet

Document Download

Research Grade Evinacumab.pdf

 

$ 328
Product specifications
100 μg 328 1 mg 1314

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Research Grade Evinacumab [DHJ88801]
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