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Research Grade Emapalumab

Catalog #:   DHB95401 Specific References (84) DATASHEET
Host species: Human
Isotype: IgG1-lambda
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DHB95401

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Human

Isotype

IgG1-lambda

Clonality

Monoclonal

Target

Interferon gamma, IFN-gamma, Immune interferon, IFNG

Concentration

5 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P01579

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

NI-0501, emapalumab-lzsg, CAS: 1709815-23-5

Clone ID

Emapalumab

Data Image
  • SDS-PAGE
    SDS PAGE for Emapalumab
References

Emapalumab in Children with Primary Hemophagocytic Lymphohistiocytosis, PMID: 32374962

Emapalumab for the treatment of hemophagocytic lymphohistiocytosis, PMID: 32648854

Emapalumab for the treatment of relapsed/refractory hemophagocytic lymphohistiocytosis, PMID: 31537529

Emapalumab: First Global Approval, PMID: 30623346

Emapalumab, PMID: 31643285

Emapalumab, PMID: 30694625

Emapalumab in Primary Hemophagocytic Lymphohistiocytosis, PMID: 32757534

Emapalumab in Primary Hemophagocytic Lymphohistiocytosis. Reply, PMID: 32757535

COVID-19: Review on latest available drugs and therapies against SARS-CoV-2. Coagulation and inflammation cross-talking, PMID: 32569708

Novel Therapeutic Approaches to Familial HLH (Emapalumab in FHL), PMID: 33424859

Antibodies to watch in 2019, PMID: 30516432

Emapalumab for adult and pediatric patients with hemophagocytic lymphohistiocytosis, PMID: 33686916

Emapalumab treatment in an ADA-SCID patient with refractory hemophagocytic lymphohistiocytosis-related graft failure and disseminated bacillus Calmette-Guérin infection, PMID: 32817285

A novel disorder involving dyshematopoiesis, inflammation, and HLH due to aberrant CDC42 function, PMID: 31601675

Treatment of refractory hemophagocytic lymphohistiocytosis with emapalumab despite severe concurrent infections, PMID: 30617216

Successful treatment of secondary macrophage activation syndrome with emapalumab in a patient with newly diagnosed adult-onset Still's disease: case report and review of the literature, PMID: 32793731

Can emapalumab be life saving for refractory, recurrent, and progressive cytokine storm caused by COVID-19, which is resistant to anakinra, tocilizumab, and Janus kinase inhibitors, PMID: 34169908

Combined use of emapalumab and ruxolitinib in a patient with refractory hemophagocytic lymphohistiocytosis was safe and effective, PMID: 33754483

Adult haemophagocytic lymphohistiocytosis: a Review, PMID: 31943120

Afebrile S. aureus bacteremia in two patients with hemophagocytic lymphohistiocytosis receiving emapalumab/dexamethasone/etoposide, PMID: 33751768

Role of interferon-γ in immune-mediated graft failure after allogeneic hematopoietic stem cell transplantation, PMID: 30792213

The role of interferon-gamma and its signaling pathway in pediatric hematological disorders, PMID: 33484058

Antibodies to watch in 2018, PMID: 29300693

Estimating health state utilities in hemophagocytic lymphohistiocytosis, PMID: 33471193

Virus-triggered secondary hemophagocytic lymphohistiocytosis, PMID: 34096649

Thinking Beyond HLH: Clinical Features of Patients with Concurrent Presentation of Hemophagocytic Lymphohistiocytosis and Thrombotic Microangiopathy, PMID: 32447592

Genetic Deficiency of Interferon-γ Reveals Interferon-γ-Independent Manifestations of Murine Hemophagocytic Lymphohistiocytosis, PMID: 31400073

Antibodies to watch in 2017, PMID: 27960628

Case Report: Rapid Recognition and Immune Modulation of Secondary HLH Due to Disseminated HSV Infection, PMID: 34277520

Chronic Graft-Versus-Host-Disease-Related Polymyositis: a 17-Months-Old Child with a Rare and Late Complication of Haematopoietic Stem Cell Transplantation, PMID: 31934312

Clinical Management of Relapsed/Refractory Hemophagocytic Lymphohistiocytosis in Adult Patients: A Review of Current Strategies and Emerging Therapies, PMID: 33888986

Systemic and Nodular Hyperinflammation in a Patient with Refractory Familial Hemophagocytic Lymphohistiocytosis 2, PMID: 33570715

The Use of Biologic Modifiers as a Bridge to Hematopoietic Cell Transplantation in Primary Immune Regulatory Disorders, PMID: 34248986

T Cell-Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis (HLH) Occurs in Non-Asians and Is Associated with a T Cell Activation State that Is Comparable to Primary HLH, PMID: 34173902

X-Linked Lymphoproliferative Disease Mimicking Multisystem Inflammatory Syndrome in Children-A Case Report, PMID: 34414143

Non-genotoxic conditioning facilitates hematopoietic stem cell gene therapy for hemophilia A using bioengineered factor VIII, PMID: 34141826

Emapalumab treatment in rheumatologic disease-associated hemophagocytic lymphohistiocytosis: a plain language summary., PMID:40528399

Management of Refractory Malignancy-Associated Hemophagocytic Lymphohistiocytosis in Adolescent Patients: A Case Series of Novel Therapeutics and Treatment Challenges., PMID:40407638

Case Report: Successful use of emapalumab in adult B-cell acute lymphoblastic leukemia experiencing severe neurotoxicity and hemophagocytic lymphohistiocytosis-like features after CAR-T cell therapy., PMID:40255392

Emapalumab for severe cytokine release syndrome in solid tumor CAR-T: a case report., PMID:40236652

Specific drugs for rare diseases in a province of eastern China under catalog management: from 2021 to 2023., PMID:40230685

Macrophage activation syndrome successfully treated with eculizumab and emapalumab: a case report., PMID:40196116

CXCL9 and IL-18: potential biomarkers for efficacy evaluation in refractory hemophagocytic lymphohistiocytosis treated with RED (ruxolitinib, emapalumab and dexamethasone)., PMID:40186662

Macrophage Activation Syndrome: Not Just for Rheumatologists Anymore., PMID:40133144

Comment on: Acute respiratory distress syndrome after emapalumab treatment in a child with severe Still's disease and lung involvement: a case report., PMID:40036577

Emapalumab in Patients With Macrophage Activation Syndrome Associated With Still's Disease: A Population Pharmacokinetic/Pharmacodynamic Analysis., PMID:39943917

Salvage treatment of AOSD-associated macrophage activation syndrome with bariticinib following conventional immunosuppressive therapy., PMID:39939513

Refractory MDA-5 dermatomyositis rapidly progressive interstitial lung disease successfully treated with emapalumab., PMID:39893100

Pediatric Transplant and Cellular Therapy Consortium RESILIENT Conference on Pediatric Chronic Graft-versus-Host Disease Survivorship after Hematopoietic Cell Transplantation: Part II. Organ Dysfunction and Immune Reconstitution Considerations for Children with Chronic Graft-versus-Host Disease after Hematopoietic Cell Transplantation., PMID:39855565

Low-dose emapalumab combined with chemotherapy for adult patients with Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis., PMID:39719162

Malignancy-associated HLH: mechanisms, diagnosis, and treatment of a severe hyperinflammatory syndrome., PMID:39656557

Efficacy of emapalumab in the management of anti‑CD19 chimeric antigen receptor T‑cell therapy‑associated cytokine release syndrome: A report of two cases., PMID:39628826

Emapalumab for the Treatment of Immune-Mediated Graft Failure after HSCT., PMID:39627345

Cytokine testing and challenges for diagnostic and clinical monitoring use., PMID:39613111

Acute respiratory distress syndrome after emapalumab treatment in a child with severe Still's disease and lung involvement: a case report., PMID:39602784

Hemophagocytic lymphohistiocytosis: current treatment advances, emerging targeted therapy and underlying mechanisms., PMID:39511607

Emapalumab as a therapeutic intervention for Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis: A case series., PMID:39331881

Efficacy and safety of therapies for Still's disease and macrophage activation syndrome (MAS): a systematic review informing the EULAR/PReS guidelines for the management of Still's disease., PMID:39317415

Systemic T-cell activation and IFN-γ activity in indeterminate severe hepatitis are reminiscent of hemophagocytic lymphohistiocytosis: Implications for T-cell- and IFN-γ-directed therapies., PMID:39278359

Emapalumab Treatment in Patients With Rheumatologic Disease-Associated Hemophagocytic Lymphohistiocytosis in the United States: A Retrospective Medical Chart Review Study., PMID:39245963

Emapalumab therapy for hemophagocytic lymphohistiocytosis before reduced-intensity transplantation improves chimerism., PMID:39190435

Salvage Therapy and Allogeneic Hematopoietic Cell Transplantation for the Severe Cytokine Storm Syndrome of Hemophagocytic Lymphohistiocytosis., PMID:39117843

Anti-Interferon-γ Therapy for Cytokine Storm Syndromes., PMID:39117840

Cytokine Storm and Sepsis-Induced Multiple Organ Dysfunction Syndrome., PMID:39117832

Current treatment in macrophage activation syndrome worldwide: a systematic literature review to inform the METAPHOR project., PMID:39058514

Successful Treatment of Severe Steroid-Resistant Engraftment Syndrome Following Haploidentical Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia with Emapalumab: A Case Report., PMID:38855328

Inhibition of interferon gamma impairs induction of experimental epidermolysis bullosa acquisita., PMID:38799441

Emapalumab as salvage therapy for adults with malignancy-associated hemophagocytic lymphohistiocytosis., PMID:38752279

Case report: emapalumab treatment for a pediatric Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) patient with cytokine storm enabling allogeneic hematopoietic cell transplantation., PMID:38715677

Combined Use of Emapalumab With Ruxolitinib and Dexamethasone as an Effective Treatment for Epstein-Barr Virus-associated Hemophagocytic Lymphohistiocytosis Complicated With Multiorgan Damage and Severe Infection., PMID:38691058

Population Pharmacokinetics of the Anti-Interferon-Gamma Monoclonal Antibody Emapalumab: An Updated Analysis., PMID:38662147

Combined emapalumab and ruxolitinib in patients with haemophagocytic Lymphohistiocytosis., PMID:38658542

Does your unwell patient have haemophagocytic lymphohistiocytosis?, PMID:38557089

Real-world treatment patterns and outcomes in patients with primary hemophagocytic lymphohistiocytosis treated with emapalumab., PMID:38429096

Successful Treatment of Refractory EBV-Associated Hemophagocytic Lymphohistiocytosis with Combined Emapalumab and PD-1 Blockade., PMID:38400989

Case Report: Refractory macrophage activation syndrome requiring high-dose anakinra, emapalumab, and etoposide therapy in early-onset systemic juvenile idiopathic arthritis associated with adenoviremia., PMID:38322244

Case Report: Successful avoidance of etoposide for primary hemophagocytic lymphohistiocytosis-induced multiple organ dysfunction syndrome using emapalumab., PMID:38304439

Editorial: Emerging talents in primary immunodeficiencies: 2022., PMID:38077356

Exposure-safety relationship for patients with primary hemophagocytic lymphohistiocytosis treated with emapalumab., PMID:38014905

Survival in primary hemophagocytic lymphohistiocytosis, 2016 to 2021: etoposide is better than its reputation., PMID:37992218

Schuelke MR, Bassiri H, Behrens EM, et al. Emapalumab for the treatment of refractory cytokine release syndrome in pediatric patients. Blood Adv. 2023;7(18):5603-5607., PMID:37966846

Emapalumab for the treatment of refractory cytokine release syndrome in pediatric patients., PMID:37721859

Emapalumab as bridge to hematopoietic cell transplant for STAT1 gain-of-function mutations., PMID:37367708

Neutralizing IFNγ improves safety without compromising efficacy of CAR-T cell therapy in B-cell malignancies., PMID:37296093

Datasheet

Document Download

Research Grade Emapalumab.pdf

 

$ 328
Product specifications
100 μg 328 1 mg 1314

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Research Grade Emapalumab [DHB95401]
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