Catalog No.
YHG41801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Ala250
Predicted molecular weight
30.38 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13136
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PPFIA1, LIP1, Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1, PTPRF-interacting protein alpha-1, LIP-1, LAR-interacting protein 1, Liprin-alpha-1
The liprin-α/RIM complex regulates the dynamic assembly of presynaptic active zones via liquid-liquid phase separation., PMID:40493522
VBP1 promotes tumor proliferation as a part of the hypoxia-related signature in esophageal squamous cell carcinoma., PMID:38700744
Liprin-α1 contributes to oncogenic MAPK signaling by counteracting ERK activity., PMID:38264964
High expression of PPFIA1 in human esophageal squamous cell carcinoma correlates with tumor metastasis and poor prognosis., PMID:37158817
Clinicopathological Significances and Prognostic Value of PPFIA4 in Colorectal Cancer., PMID:36605492
High PPFIA1 expression promotes cancer survival by suppressing CD8+ T cells in breast cancer: drug discovery and machine learning approach., PMID:36478321
Differential newborn DNA methylation among individuals with complex congenital heart defects and childhood lymphoma., PMID:36226634
Two circPPFIA1s negatively regulate liver metastasis of colon cancer via miR-155-5p/CDX1 and HuR/RAB36., PMID:36224588
Quantifying Polarized Extracellular Matrix Secretion in Cultured Endothelial Cells., PMID:33215388
IL1RAP regulated by PRPRD promotes gliomas progression via inducing neuronal synapse development and neuron differentiation in vitro., PMID:32829106
circ_0080145 Enhances Imatinib Resistance of Chronic Myeloid Leukemia by Regulating miR-326/PPFIA1 Axis., PMID:32598170
PPFIA1 expression associates with poor response to endocrine treatment in luminal breast cancer., PMID:32410585
Characterization of the polarized endothelial secretome., PMID:31431053
The molecular differences between human papillomavirus-positive and -negative oropharyngeal squamous cell carcinoma: A bioinformatics study., PMID:31036418
Discovery of the Oncogenic Parp1, a Target of bcr-abl and a Potential Therapeutic, in mir-181a/PPFIA1 Signaling Pathway., PMID:30825668
Combined expression and prognostic significance of PPFIA1 and ALG3 in head and neck squamous cell carcinoma., PMID:30805892
Structural basis of the target-binding mode of the G protein-coupled receptor kinase-interacting protein in the regulation of focal adhesion dynamics., PMID:30737283
Cell adhesion-related gene somatic mutations are enriched in aggressive papillary thyroid microcarcinomas., PMID:30285776
Oncogenic drivers in 11q13 associated with prognosis and response to therapy in advanced oropharyngeal carcinomas., PMID:30098783
Regulation of KIF1A-Driven Dense Core Vesicle Transport: Ca2+/CaM Controls DCV Binding and Liprin-α/TANC2 Recruits DCVs to Postsynaptic Sites., PMID:30021165
Liprin-α1 modulates cancer cell signaling by transmembrane protein CD82 in adhesive membrane domains linked to cytoskeleton., PMID:30005669
Loss of C/EBP-β LIP drives cisplatin resistance in malignant pleural mesothelioma., PMID:29748013
Identification of a membrane-less compartment regulating invadosome function and motility., PMID:29348417
Proteomic analysis reveals novel ligands and substrates for LNX1 E3 ubiquitin ligase., PMID:29121065
Liprin-α-1 is a novel component of the murine neuromuscular junction and is involved in the organization of the postsynaptic machinery., PMID:28831123
Cdk5-dependent phosphorylation of liprinα1 mediates neuronal activity-dependent synapse development., PMID:28760951
PPFIA1 is upregulated in liver metastasis of breast cancer and is a potential poor prognostic indicator of metastatic relapse., PMID:28720060
Korean atrial fibrillation network genome-wide association study for early-onset atrial fibrillation identifies novel susceptibility loci., PMID:28460022
Decreased Anxiety-Related Behaviour but Apparently Unperturbed NUMB Function in Ligand of NUMB Protein-X (LNX) 1/2 Double Knockout Mice., PMID:27889896
PPFIA1 drives active α5β1 integrin recycling and controls fibronectin fibrillogenesis and vascular morphogenesis., PMID:27876801
Structural insight into GRIP1-PDZ6 in Alzheimer's disease: study from protein expression data to molecular dynamics simulations., PMID:27425598
ELKS controls the pool of readily releasable vesicles at excitatory synapses through its N-terminal coiled-coil domains., PMID:27253063
Liprin-α1 is a regulator of vimentin intermediate filament network in the cancer cell adhesion machinery., PMID:27075696
CASK stabilizes neurexin and links it to liprin-α in a neuronal activity-dependent manner., PMID:27015872
Role of Liprins in the Regulation of Tumor Cell Motility and Invasion., PMID:26882029
Effects of the scaffold proteins liprin-α1, β1 and β2 on invasion by breast cancer cells., PMID:26663347
Identifying genes that mediate anthracyline toxicity in immune cells., PMID:25926793
The PPFIA1-PP2A protein complex promotes trafficking of Kif7 to the ciliary tip and Hedgehog signaling., PMID:25492966
Interaction between insulin-like growth factor-1 and atherosclerosis and vascular aging., PMID:24943302
Prognostic significance of TMEM16A, PPFIA1, and FADD expression in invasive ductal carcinoma of the breast., PMID:24886289
WsSGTL1 gene from Withania somnifera, modulates glycosylation profile, antioxidant system and confers biotic and salt stress tolerance in transgenic tobacco., PMID:24610300
CFEOM1-associated kinesin KIF21A is a cortical microtubule growth inhibitor., PMID:24120883
Direct RNA sequencing mediated identification of mRNA localized in protrusions of human MDA-MB-231 metastatic breast cancer cells., PMID:24004954
Erratum to: the acaricidal efficacy of peracetic acid and deltamethrin against the fowl tick, Argas persicus, infesting laying hens., PMID:23955563
Amplification of the PPFIA1 gene region on 11q13 in oral squamous cell carcinomas (OSCC)., PMID:23453270
Liprin α3: a putative estrogen regulated acrosomal protein., PMID:23124857
Genome wide association identifies PPFIA1 as a candidate gene for acute lung injury risk following major trauma., PMID:22295056
Liprin-α controls stress fiber formation by binding to mDia and regulating its membrane localization., PMID:22266902
The Liprin homology domain is essential for the homomeric interaction of SYD-2/Liprin-α protein in presynaptic assembly., PMID:22072677
Liprin-α4 is required for nickel induced receptor protein tyrosine phosphatase-leukocyte antigen related receptor F (RPTP-LAR) activity., PMID:21829649
For research use only. Not for human or drug use.
