Catalog No.
YHG40801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys6-Lys351
Predicted molecular weight
41.78 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13114
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CAP-1, RING-type E3 ubiquitin transferase TRAF3, LAP1, LMP1-associated protein 1, TRAF3, CD40-binding protein, TNF receptor-associated factor 3, CD40BP, CAP1, CRAF1, CD40 receptor-associated factor 1
Otubain 2 stabilizes TNF‑receptor associated factor 3 to accelerate bone fracture healing., PMID:40476556
TRAF3 as a potential diagnostic biomarker for recurrent pregnancy loss: insights from single-cell transcriptomics and machine learning., PMID:40450232
N-glycosylated LTβR increases the Th17/Treg cell ratio in liver cancer by blocking RORC ubiquitination and FOXP3 transcription., PMID:40436857
Integrated multi-omics insight into the molecular networks of oxidative stress in triggering multiple sclerosis., PMID:40280189
Genome-wide identification of TRAF family genes in Urechis unicinctus (Annelida, Echiura) and their responses in resistance to high temperature stress., PMID:40267861
[Comprehensive Analysis of the Expression, Prognosis and Function of TRAF Family Proteins
in NSCLC]., PMID:40210478
Lipid peroxidation and immune activation: TRAF3's double-edged strategy against glioblastoma., PMID:40166928
Ubiquitin Ligases in Control: Regulating NLRP3 Inflammasome Activation., PMID:40152367
Multi-Omics Analysis of Hippocampus in Rats Administered Trimethyltin Chloride., PMID:40095120
AGR2-mediated cell-cell communication controls the antiviral immune response by promoting the thiol oxidation of TRAF3., PMID:40085973
TRAF3IP3 Induces ER Stress-Mediated Apoptosis with Protective Autophagy to Inhibit Lung Adenocarcinoma Proliferation., PMID:40068093
Establishment and characterisation of a novel canine mast cell tumour cell line (C18)., PMID:40050946
A genome-wide CRISPR-Cas9 knockout screen using dynamin knockout cells identifies Nf2 and Traf3 as genes involved in dynamin-independent endocytosis., PMID:39978713
Siglec-E augments adipose tissue inflammation by modulating TRAF3 signaling and monocytic myeloid-derived suppressor cells during obesity., PMID:39967660
GIT2 negatively regulates the NF-κB pathway directly or indirectly by regulating TRAF3 expression to promote osteogenic differentiation of BMSCs., PMID:39954559
Bioinformatics analysis and validation of novel biomarkers and competitive endogenous RNA networks involved in pyroptosis in diabetic nephropathy., PMID:39953123
TRAF3 is critical for initial T follicular helper cell specification via coordination of the IL-6R/IL-2R-BCL6 signaling nexus., PMID:39951546
Prenatal exposure to an environmentally relevant phthalate mixture alters oxidative stress, apoptosis, cell cycle regulators, and steroidogenic factors in the ovaries of F1 mice., PMID:39947446
Tim-3 promotes viral infection by suppressing the USP25-TRAF3-IRF7 signaling pathway., PMID:39946759
Cannabidiol-loaded hydrogel microneedle patches inhibit TRIM14/TRAF3/ NF-κB axis for the treatment of psoriasis., PMID:39933682
TRAF3 loss protects glioblastoma cells from lipid peroxidation and immune elimination via dysregulated lipid metabolism., PMID:39932808
Mechanisms of resveratrol in alleviating diabetic nephropathy: focus on tumor necrosis factor receptor-related factor expression and toll-like reeptor 4/nuclear factor-kappaB signaling pathway., PMID:39923228
Characterization of the genomic landscape of canine diffuse large B-cell lymphoma reveals recurrent H3K27M mutations linked to progression-free survival., PMID:39922874
Identification of potential biomarkers associated with cuproptosis and immune microenvironment analysis in acute myocardial infarction: A diagnostic accuracy study., PMID:39889200
MicroRNA-203-3p participates in antiviral immune response by negatively regulating TRAF3 in the rainbow trout (Oncorhynchus mykiss)., PMID:39864565
eEF-2K Deficiency Boosts the Virus-Specific Effector CD8+ T Cell Responses During Viral Infection., PMID:39861816
Study of TRAF3IP3 for prognosis and immune infiltration in hepatocellular carcinoma., PMID:39677949
USP33 PROMOTES CERULEIN-INDUCED APOPTOTIC, OXIDATIVE, AND INFLAMMATORY INJURIES IN ACUTE PANCREATITIS BY DEUBIQUITINATING TRAF3., PMID:39637362
Heterozygous Predicted Loss-of-function Variants of TRAF3 in Patients with Common Variable Immunodeficiency., PMID:39579173
IP-10 acts early in CV-A16 infection to induce BBB destruction and promote virus entry into the CNS by increasing TNF-α expression., PMID:39559356
circAGO3 facilitates NF-κB pathway-mediated inflammatory atrophy in chicken skeletal muscle via the miR-34b-5p/TRAF3 axis., PMID:39549809
EF24, a Curcumin Analog, Reverses Interleukin-18-Induced miR-30a or miR-342-Dependent TRAF3IP2 Expression, RECK Suppression, and the Proinflammatory Phenotype of Human Aortic Smooth Muscle Cells., PMID:39451191
Cardiomyocyte-specific knockout of ADAM17 alleviates doxorubicin-induced cardiomyopathy via inhibiting TNFα-TRAF3-TAK1-MAPK axis., PMID:39406701
NOD2-mediated dual negative regulation of inflammatory responses triggered by TLRs in the gastrointestinal tract., PMID:39403381
Stress triggers irritable bowel syndrome with diarrhea through a spermidine-mediated decline in type I interferon., PMID:39366386
Members of the TRAF gene family in Octopus sinensis and their response to PGN, poly I:C, and Vibrio parahaemolyticus., PMID:39276812
The immune function of TLR4-1 gene in Octopus sinensis revealed by RNAi and RNA-seq., PMID:39265964
TRAF3 regulates STAT6 activation and T-helper cell differentiation by modulating the phosphatase PTP1B., PMID:39233229
Hydroxychloroquine and a low antiresorptive activity bisphosphonate conjugate prevent and reverse ovariectomy-induced bone loss in mice through dual antiresorptive and anabolic effects., PMID:39231935
RANKL/RANK contributes to the pathological process of type 2 diabetes mellitus through TRAF3 activation of NIK., PMID:39217877
A Viral-Encoded Homologue of IPS-1 Modulates Innate Immune Signaling During KSHV Lytic Replication., PMID:39211267
Hepatocyte-Specific Casein Kinase 1 Epsilon Ablation Ameliorates Metabolic Dysfunction-Associated Steatohepatitis by Up-Regulating Tumor Necrosis Factor Receptor-Associated Factor 3 in Mice., PMID:39179201
LMP1 enhances aerobic glycolysis in natural killer/T cell lymphoma., PMID:39164228
PUM1-TRAF3 fusion protein activates non-canonical NF-κB signaling via rescued NIK in biliary tract cancer., PMID:39090283
USP26 suppresses type I interferon signaling by targeting TRAF3 for deubiquitination., PMID:39058724
Downregulation of miR-1388 Regulates the Expression of Antiviral Genes via Tumor Necrosis Factor Receptor (TNFR)-Associated Factor 3 Targeting Following poly(I:C) Stimulation in Silver Carp (Hypophthalmichthys molitrix)., PMID:38927097
Grouper OTUB1 and OTUB2 promote red-spotted grouper nervous necrosis virus (RGNNV) replication by inhibiting the host innate immune response., PMID:38909637
RNF216 Inhibits the Replication of H5N1 Avian Influenza Virus and Regulates the RIG-I Signaling Pathway in Ducks., PMID:38829131
Biologically significant interaction of human herpesvirus 8 viral interferon regulatory factor 4 with ubiquitin-specific protease 7., PMID:38752725
Hydroxychloroquine and a low activity bisphosphonate conjugate prevent and reverse ovariectomy-induced bone loss in mice through dual antiresorptive and anabolic effects., PMID:38746138
For research use only. Not for human or drug use.
