Catalog No.
YHG41601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met10-Gln559
Predicted molecular weight
65.12 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13131
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
AMPK subunit alpha-1, Acetyl-CoA carboxylase kinase, Tau-protein kinase PRKAA1, ACACA kinase, Hydroxymethylglutaryl-CoA reductase kinase, 5'-AMP-activated protein kinase catalytic subunit alpha-1, AMPK1, PRKAA1, HMGCR kinase
Daily acute intermittent hypoxia elicits age & sex-dependent changes in molecules regulating phrenic motor plasticity., PMID:40204197
Alpha protein kinase 1 knockout mitigates microglial pyroptosis and cognition deficits in ADP-heptose-stimulated mice., PMID:39902886
[Artificial light at night effects glucose metabolism in the developing jawbone by inhibiting melatonin secretion]., PMID:39848802
AMP-dependent protein kinase alpha 1 predicts cancer prognosis and immunotherapy response: from pan-cancer analysis to experimental validation., PMID:39553228
Hesperitin prevents non-alcoholic steatohepatitis by modulating mitochondrial dynamics and mitophagy via the AMPKα-Drp1/PINK1-Parkin signaling pathway., PMID:39454819
RNA-seq analysis of mitochondria-related genes regulated by AMPK in the human trophoblast cell line BeWo., PMID:39445545
Dorsomedial Ventromedial Hypothalamic Nucleus Growth Hormone-Releasing Hormone Neuron Steroidogenic Factor-1 Gene Targets in Female Rat., PMID:39401164
Mir221- and Mir222-enriched adsc-exosomes mitigate PM exposure-exacerbated cardiac ischemia-reperfusion injury through the modulation of the BNIP3-MAP1LC3B-BBC3/PUMA pathway., PMID:39245438
Electroacupuncture activates AMPKα1 to improve learning and memory in the APP/PS1 mouse model of early Alzheimer's disease by regulating hippocampal mitochondrial dynamics., PMID:39181774
Maternal AMPK pathway activation with uterine artery blood flow and fetal growth maintenance during hypoxia., PMID:39028630
Bayesian mapping of protein kinases to vasopressin-regulated phosphorylation sites in renal collecting duct., PMID:39024358
Variances in the Expression Profile of Circadian Clock-Related Genes in Astrocytic Brain Tumors., PMID:39001398
Metabolic stress induces a double-positive feedback loop between AMPK and SQSTM1/p62 conferring dual activation of AMPK and NFE2L2/NRF2 to synergize antioxidant defense., PMID:38953310
Sex-Dimorphic Effects of Hypoglycemia on Metabolic Sensor mRNA Expression in Ventromedial Hypothalamic Nucleus-Dorsomedial Division (VMNdm) Growth Hormone-Releasing Hormone Neurons., PMID:38757688
AMPK/MTOR/TP53 Signaling Pathway Regulation by Calcitonin Gene-Related Peptide Reduces Oxygen-Induced Lung Damage in Neonatal Rats through Autophagy Promotion., PMID:38502251
Ameliorating the impairment of glucose utilization in a high-fat diet-induced obesity model through the consumption of Tucum-do-Cerrado (Bactris Setosa Mart.)., PMID:38206915
ZNFX1 promotes AMPK-mediated autophagy against Mycobacterium tuberculosis by stabilizing Prkaa2 mRNA., PMID:38016036
Gene expression of protein kinase AMP-activated catalytic subunit alpha 1 (PRKAA1), solute carrier family 2 member 1 (SLC2A1) and mechanistic target of rapamycin (MTOR) in metformin-treated type 2 diabetes patients with COVID-19: impact on inflammation markers., PMID:37773574
Loss of Mature Lamin A/C Triggers a Shift in Intracellular Metabolic Homeostasis via AMPKα Activation., PMID:36552752
Circ_0003340 downregulation mitigates esophageal squamous cell carcinoma progression by targeting miR-940/PRKAA1 axis., PMID:35297212
The Energy Sensor AMPKα1 Is Critical in Rapamycin-Inhibition of mTORC1-S6K-Induced T-cell Memory., PMID:35008461
Negative pressure wound therapy improves bone regeneration by promoting osteogenic differentiation via the AMPK-ULK1-autophagy axis., PMID:34964701
Prosurvival IL-7-Stimulated Weak Strength of mTORC1-S6K Controls T Cell Memory via Transcriptional FOXO1-TCF1-Id3 and Metabolic AMPKα1-ULK1-ATG7 Pathways., PMID:34872976
Full-coverage regulations of autophagy by ROS: from induction to maturation., PMID:34662529
CircC6orf132 Facilitates Proliferation, Migration, Invasion, and Glycolysis of Gastric Cancer Cells Under Hypoxia by Acting on the miR-873-5p/PRKAA1 Axis., PMID:34659329
Resveratrol induces proliferation in preosteoblast cell MC3T3-E1 via GATA-1 activating autophagy., PMID:34637502
FLT4/VEGFR3 activates AMPK to coordinate glycometabolic reprogramming with autophagy and inflammasome activation for bacterial elimination., PMID:34632918
Autophagy-dependent glutaminolysis drives superior IL21 production in HIV-1-specific CD4 T cells., PMID:34612140
High Expression of Citron Kinase Contributes to the Development of Esophageal Squamous Cell Carcinoma., PMID:34305997
LANCL1 binds abscisic acid and stimulates glucose transport and mitochondrial respiration in muscle cells via the AMPK/PGC-1α/Sirt1 pathway., PMID:34098144
Cereblon contributes to the development of pulmonary fibrosis via inactivation of adenosine monophosphate-activated protein kinase α1., PMID:34002012
MTFR2, A Potential Biomarker for Prognosis and Immune Infiltrates, Promotes Progression of Gastric Cancer Based on Bioinformatics Analysis and Experiments., PMID:33995638
Manassantin B attenuates obesity by inhibiting adipogenesis and lipogenesis in an AMPK dependent manner., PMID:33904622
TNF-induced necroptosis initiates early autophagy events via RIPK3-dependent AMPK activation, but inhibits late autophagy., PMID:33779513
Artemisinin improves neurocognitive deficits associated with sepsis by activating the AMPK axis in microglia., PMID:33758353
Hydrogen sulfide-induced GAPDH sulfhydration disrupts the CCAR2-SIRT1 interaction to initiate autophagy., PMID:33459133
MiRNA-seq analysis of spleen and head kidney tissue from aquacultured largemouth bass (Micropterus salmoides) in response to Aeromonas hydrophila infection., PMID:33442859
Brain-Derived Neurotrophic Factor Improves Impaired Fatty Acid Oxidation Via the Activation of Adenosine Monophosphate-Activated Protein Kinase-ɑ - Proliferator-Activated Receptor-r Coactivator-1ɑ Signaling in Skeletal Muscle of Mice With Heart Failure., PMID:33356364
The protein tyrosine phosphatase PTP-PEST mediates hypoxia-induced endothelial autophagy and angiogenesis via AMPK activation., PMID:33323505
AMPKα1 regulates Idh2 transcription through H2B O-GlcNAcylation during brown adipogenesis., PMID:33219380
AMPKα1 Regulates Lung and Breast Cancer Progression by Regulating TLR4-Mediated TRAF6-BECN1 Signaling Axis., PMID:33172060
LINC01315 silencing inhibits the aggressive phenotypes of colorectal carcinoma by sponging miR-205-3p., PMID:33162032
Keratinocyte autophagy enables the activation of keratinocytes and fibroblastsand facilitates wound healing., PMID:32866426
Ameliorative effects and molecular mechanisms of vine tea on western diet-induced NAFLD., PMID:32666969
The AMPK pathway triggers autophagy during CSF1-induced microglial activation and may be implicated in inducing neuropathic pain., PMID:32570135
[The Regulation of AMPKα1/Nrf2/ HO-1 Pathway Mediated by Galantamine Hydrobromide Lycoremine in Myocardial Ischemia Reperfusion Rats]., PMID:32543139
Chronic glucokinase activator treatment activates liver Carbohydrate response element binding protein and improves hepatocyte ATP homeostasis during substrate challenge., PMID:32519798
β-elemene suppresses Warburg effect in NCI-H1650 non-small-cell lung cancer cells by regulating the miR-301a-3p/AMPKα axis., PMID:32463461
Melatonin improves mitochondrial biogenesis through the AMPK/PGC1α pathway to attenuate ischemia/reperfusion-induced myocardial damage., PMID:32305957
Geniposide alleviates non-alcohol fatty liver disease via regulating Nrf2/AMPK/mTOR signalling pathways., PMID:32293113
For research use only. Not for human or drug use.
