Catalog No.
YHG42701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser12-Glu206
Predicted molecular weight
24.18 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13158
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Growth-inhibiting gene 3 protein, Mediator of receptor induced toxicity, MORT1, FAS-associating death domain-containing protein, FAS-associated death domain protein, FADD, Protein FADD
Anoikis classification of lung squamous cell carcinoma reveals correlation with clinical prognosis and immune characteristics., PMID:40515636
Nuclear respiratory factor-1 promotes CFLAR transcription in H9C2 cardiomyocytes, protecting them against hypoxia-induced apoptosis., PMID:40478441
Clinical characteristics and genetic features of 35 cases of adverse reactions to Bacillus Calmette-Guérin vaccine in children., PMID:40470261
Assembly and activation of the death-inducing signaling complex., PMID:40465623
Venetoclax used alone, or in combination with cladribine, changes the expression of apoptosis-regulating genes in chronic lymphocytic leukemia cells in vitro., PMID:40432340
Genetic Determinants of Colonic Diverticulosis-A Systematic Review., PMID:40428403
Active compounds of licorice ameliorate microplastics-induced intestinal damage by targeting FADD., PMID:40412644
Kindlin-2 silencing promoted apoptosis and cell cycle arrest through the fas/FasL pathway in hepatocellular carcinoma., PMID:40392106
Ionized Angelica polysaccharides derivatives slow tumor growth in vivo and induce the apoptosis of HepG2 cells via mitochondria death receptor-mediated pathways in vitro., PMID:40383338
FADD Functions as an Oncogene in Chr11q13.3-Amplified Head and Neck Squamous Cell Carcinoma., PMID:40370064
Cytotoxicity evaluation of Curcuma aromatica Salisb. rhizome extract via apoptosis and reactive oxygen species generation in human gastric cancer cells., PMID:40342537
Resting-State fMRI and Post-Ischemic Stroke Functional Recovery: Unraveling Causality and Predicting Therapeutic Targets., PMID:40332106
Identification and Verification of Necroptosis-Related Genes in Patients With Sepsis by Bioinformatic Analysis and Molecular Experiments., PMID:40318009
Xanthatin induces apoptosis through ROS-mediated c-FLIP inhibition in human retinoblastoma cells., PMID:40309730
Cell death and antioxidant responses in Mytilus galloprovincialis under heat stress: Evidence of genetic loci potentially associated with thermal resilience., PMID:40267109
Intelectin-1 promotes granulosa cells proliferation and modulates apoptosis via ERK1/2, AKT, and insulin receptor signaling pathways in Large White and Meishan pigs., PMID:40250633
Oligomerised RIPK1 is the main core component of the CD95 necrosome., PMID:40240880
Physalin A induces apoptosis through conjugating with Fas-FADD cell death receptor in human oral squamous carcinoma cells and suppresses HSC-3 cell xenograft tumors in NOD/SCID mice., PMID:40239116
Potential role of CFLAR in enhancing 5-FU sensitivity and modulating immune cell infiltration in breast cancer., PMID:40211399
Nd:YAG1064nm laser functions against Sporothrix globosa by inducing PANoptosis via the regulation of ZBP1-induced PANoptosome activation., PMID:40207151
FLIPL permits apoptotic and inflammatory signaling and inhibits necroptosis in mice without Caspase-8 oligomerization., PMID:40203042
Ox-LDL Induces Neuron Apoptosis and Worsens Neurological Outcomes in aSAH via Fas/FADD Pathway., PMID:40199806
Evaluation of the Apoptotic, Prooxidative and Therapeutic Effects of Odoroside A on Lung Cancer: An In Vitro Study Extended with In Silico Analyses of Human Lung Cancer Datasets., PMID:40141789
Eupalinolide B targets DEK and PANoptosis through E3 ubiquitin ligases RNF149 and RNF170 to negatively regulate asthma., PMID:40120540
Artemetin targets the ABCG2/RAB7A axis to inhibit mitochondrial dysfunction in asthma., PMID:40088742
Enhancing WRAP-Based Nanoparticles for Small Interfering Ribonucleic Acid Delivery in pH-Sensitive Environments., PMID:40084851
[Effect of penetrative needling of "Zhibian" (BL54) through "Shuidao" (ST28) on expression of internal and external apoptosis-related factors in ovarian of mice with poor ovarian response]., PMID:40059045
MnTBAP, a peroxynitrite scavenger, attenuates cisplatin-induced apoptosis and cytotoxicity in organ of Corti cells., PMID:40046635
IL6 mediated cFLIP downregulation increases the migratory and invasive potential of triple negative breast cancer cell., PMID:39988287
Hypoxia-mediated SUMOylation of FADD exacerbates endothelial cell injury via the RIPK1-RIPK3-MLKL signaling axis., PMID:39984463
TNF/IFN-γ Co-Signaling Induces Differential Cellular Activation in COVID-19 Patients: Implications for Patient Outcomes., PMID:39940907
Fungal Als proteins hijack host death effector domains to promote inflammasome signaling., PMID:39939579
Integrated multiplex analysis of cell death regulators in stage II colorectal cancer suggests patients with 'persister' cell profiles fail to benefit from adjuvant chemotherapy., PMID:39886119
TNFAIP3-interacting protein 1 (ABIN-1) negatively regulates caspase-8/FADD-dependent pyroptosis., PMID:39827378
Exercise-induced cytosolic calcium oscillations: mechanisms and modulation of T-cell function., PMID:39826528
c-FLIP/Ku70 complex; A potential molecular target for apoptosis induction in hepatocellular carcinoma., PMID:39818348
SPOP enhances FADD degradation and decreases the activeness of the NF-κB signaling pathway in prostate cancer: an in vitro study., PMID:39816234
Amide Internucleoside Linkages Suppress the MicroRNA-like Off-Target Activity of Short Interfering RNA., PMID:39813044
RIPK3 activation of CaMKII triggers mitochondrial apoptosis in NIBV-infected renal tubular epithelial cells., PMID:39808936
FADD cooperates with Caspase-8 to positively regulate the innate immune response and promote apoptosis following bacterial infection in Japanese eel., PMID:39755288
Pharmacological targeting of caspase-8/c-FLIPL heterodimer enhances complex II assembly and elimination of pancreatic cancer cells., PMID:39753884
Factor associated suicide ligand (FasL) participates in the intestinal immune response to muramyl dipeptide challenge in grass carp Ctenopharyngodon idella., PMID:39743083
Identification of an Isoxazole Derivative as an Antitubercular Compound for Targeting the FadD Enzymes of Mycobacterium tuberculosis., PMID:39693602
Intratumoral delivery of mRNA encoding the endogenous TLR2/6 agonist UNE-C1 induces immunogenic cell death and enhances antitumor activity., PMID:39669578
Cadmium exposure induces oxidative stress-mediated necroptosis via TLR4/NF-κB signaling pathway in pig epididymis., PMID:39662580
Profiling trace organic chemical biotransformation genes, enzymes and associated bacteria in microbial model communities., PMID:39662353
Mef2c Exacerbates Neuron Necroptosis via Modulating Alternative Splicing of Cflar in Ischemic Stroke With Hyperlipidemia., PMID:39648651
Molecular docking and in silico analysis of the pharmacokinetics, toxicological profile and differential gene expression of bioactive compounds from Cyrtopodium glutiniferum., PMID:39629241
Fingolimod Inhibits C6 Rat Glioma Proliferation and Migration, Induces Sub-G1 Cell Cycle Arrest, Mitochondrial and Extrinsic Apoptosis In Vitro and Reduces Tumour Growth In Vivo., PMID:39623929
RNA-Seq Reveals Transcriptome Changes Following Zika Virus Infection in Fetal Brains in c-Flip Knockdown Mice., PMID:39599827
For research use only. Not for human or drug use.
