Catalog No.
YHF61401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Glu179
Predicted molecular weight
22.94 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P67812
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Microsomal signal peptidase 18 kDa subunit, Endopeptidase SP18, SPCS4A, Signal peptidase complex catalytic subunit SEC11A, SEC11A, SPase 18 kDa subunit, SEC11-like protein 1, SEC11 homolog A, SPC18, SEC11L1
CircSEC11A knockdown alleviates oxidative stress and apoptosis and promotes cell proliferation and angiogenesis by regulating miR-29a-3p/SEMA3A axis in OGD-induced human brain microvascular endothelial cells (HBMECs)., PMID:36872771
Cleavage of the Jaw1 C-terminal region enhances its augmentative effect on the Ca2+ release via IP3 receptors., PMID:36789796
Clinical Significance of SEC11A Expression in Patients With Locally Advanced Gastric Cancer., PMID:36456166
Gene expression profiles in parathyroid adenoma and normal parathyroid tissue., PMID:35953114
Signal peptidase complex catalytic subunit SEC11A upregulation is a biomarker of poor prognosis in patients with head and neck squamous cell carcinoma., PMID:35653344
Structure of the human signal peptidase complex reveals the determinants for signal peptide cleavage., PMID:34388369
Neoantigen-reactive T cells exhibit effective anti-tumor activity against colorectal cancer., PMID:33689574
MiR-873-5p modulates progression of tongue squamous cell carcinoma via targeting SEC11A., PMID:33675129
SPC18 Expression Is an Independent Prognostic Indicator of Patients with Esophageal Squamous Cell Carcinoma., PMID:32564026
Long non-coding RNA DDX11-AS1 facilitates gastric cancer progression by regulating miR-873-5p/SPC18 axis., PMID:32054332
SEC11A Expression Is Associated with Basal-Like Bladder Cancer and Predicts Patient Survival., PMID:31163419
Comparative Gene Expression Profiles in Parathyroid Adenoma and Normal Parathyroid Tissue., PMID:30832348
The Natural Product Cavinafungin Selectively Interferes with Zika and Dengue Virus Replication by Inhibition of the Host Signal Peptidase., PMID:28423309
Clinicopathological significance of SPC18 in colorectal cancer: SPC18 participates in tumor progression., PMID:27859949
Competitive Inhibition of the Endoplasmic Reticulum Signal Peptidase by Non-cleavable Mutant Preprotein Cargos., PMID:26446786
Archaeal membrane-associated proteases: insights on Haloferax volcanii and other haloarchaea., PMID:25774151
Signal peptidase complex 18, encoded by SEC11A, contributes to progression via TGF-α secretion in gastric cancer., PMID:23995782
Cloning, expression, and purification of functional Sec11a and Sec11b, type I signal peptidases of the archaeon Haloferax volcanii., PMID:16484202
For research use only. Not for human or drug use.
