Catalog No.
YHF63601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Leu259
Predicted molecular weight
31.26 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P78314
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
3BP-2, SH3BP2, 3BP2, SH3 domain-binding protein 2
Emerging Role of SH3BP2 as Regulator of Immune and Nonimmune Cells in Nephrotic Syndrome., PMID:39991193
The bone phenotype associated with cherubism is independent of Caspase-1-dependent inflammasome activation in the mouse., PMID:39951467
Silencing of SH3BP2 Inhibits Microglia Activation Via the JAK/STAT Signaling in Spinal Cord Injury Models., PMID:39546158
Adaptor protein 3BP2 regulates gene expression in addition to the ubiquitination and proteolytic activity of MALT1 in dectin-1-stimulated cells., PMID:39542253
PLCG2 variants in cherubism., PMID:39197752
A pilot study of childhood-onset Takayasu arteritis using whole exome sequencing suggests oligogenic inheritance involving classical complement, collagen, and autoinflammatory pathways., PMID:38869681
Loss-of-function OGFRL1 variants identified in autosomal recessive cherubism families., PMID:38699440
Scaffold protein SH3BP2 signalosome is pivotal for immune activation in nephrotic syndrome., PMID:38127456
MITF Downregulation Induces Death in Human Mast Cell Leukemia Cells and Impairs IgE-Dependent Degranulation., PMID:36834926
SH3BP2 Silencing Increases miRNAs Targeting ETV1 and Microphthalmia-Associated Transcription Factor, Decreasing the Proliferation of Gastrointestinal Stromal Tumors., PMID:36551682
A new TRPV4 mutation in a case of multiple central giant cell granulomas of the jaws., PMID:36529675
Identifying transcript-level differential expression in primary human immune cells., PMID:36527757
The microphthalmia-associated transcription factor is involved in gastrointestinal stromal tumor growth., PMID:36241703
Cherubism: a rare case report with literature review., PMID:35991385
Overexpression of DEL-1 Downregulates SH3BP2 Expression and Inhibits Porphyromonas gingivalis-induced Gingival Inflammation In Vivo and In Vitro., PMID:35481344
OC_Finder: Osteoclast segmentation, counting, and classification using watershed and deep learning., PMID:35474753
[Cherubism in three siblings]., PMID:35279646
Adaptor protein 3BP2 regulates dectin-1-mediated cellular signalling to induce cytokine expression and NF-κB activation., PMID:35129602
Tlr2/4-Mediated Hyperinflammation Promotes Cherubism-Like Jawbone Expansion in Sh3bp2 (P416R) Knockin Mice., PMID:35079675
Effect of Disease Causing Missense Mutations on Intrinsically Disordered Regions in Proteins., PMID:34825861
Imatinib has minimal effects on inflammatory and osteopenic phenotypes in a murine cherubism model., PMID:34743383
A case of recurrent pericarditis with SH3BP2 gene variant: a new pathophysiological mechanism?, PMID:34599806
SYK-3BP2 Pathway Activity in Parenchymal and Myeloid Cells Is a Key Pathogenic Factor in Metabolic Steatohepatitis., PMID:34411785
SH3BP2-related fibro-osseous disorders of the maxilla and mandible: A systematic review., PMID:33941395
SH3BP2 Deficiency Ameliorates Murine Systemic Lupus Erythematosus., PMID:33920631
Multiple versus solitary giant cell lesions of the jaw: Similar or distinct entities?, PMID:33771761
Angioid streaks and optic disc drusen in cherubism: a case report., PMID:33470282
Cherubism as a systemic skeletal disease: evidence from an aggressive case., PMID:32825821
Efficacy and safety of denosumab treatment in a prepubertal patient with cherubism., PMID:32649295
Cherubism: a systematic literature review of clinical and molecular aspects., PMID:32620450
Establishment of a novel risk score model by comprehensively analyzing the immunogen database of bladder cancer to indicate clinical significance and predict prognosis., PMID:32570217
Microbe-Dependent Exacerbated Alveolar Bone Destruction in Heterozygous Cherubism Mice., PMID:32537546
RANKL-independent osteoclastogenesis in the SH3BP2 cherubism mice., PMID:32258251
Investigating global gene expression changes in a murine model of cherubism., PMID:32165349
Bone dynamics and inflammation: lessons from rare diseases., PMID:31999934
Alveolar Bone Protection by Targeting the SH3BP2-SYK Axis in Osteoclasts., PMID:31613396
Myo1f, an Unconventional Long-Tailed Myosin, Is a New Partner for the Adaptor 3BP2 Involved in Mast Cell Migration., PMID:31143189
Sh3bp2 Gain-Of-Function Mutation Ameliorates Lupus Phenotypes in B6.MRL-Faslpr Mice., PMID:31052273
A Paradigm Shift in the Management of Cherubism? A Preliminary Report Using Imatinib., PMID:30880133
Tankyrase (PARP5) Inhibition Induces Bone Loss through Accumulation of Its Substrate SH3BP2., PMID:30813388
Novel ANO5 mutation c.1067G>T (p.C356F) identified by whole genome sequencing in a big family with atypical gnathodiaphyseal dysplasia., PMID:30554457
Molecular and cellular characterizations of human cherubism: disease aggressiveness depends on osteoclast differentiation., PMID:30236129
Timed Regulation of 3BP2 Induction Is Critical for Sustaining CD8+ T Cell Expansion and Differentiation., PMID:30067970
Silencing of adaptor protein SH3BP2 reduces KIT/PDGFRA receptors expression and impairs gastrointestinal stromal tumors growth., PMID:29885053
Second-Generation SYK Inhibitor Entospletinib Ameliorates Fully Established Inflammation and Bone Destruction in the Cherubism Mouse Model., PMID:29669173
Rescue of a cherubism bone marrow stromal culture phenotype by reducing TGFβ signaling., PMID:29530719
Pharmacological inhibition of tankyrase induces bone loss in mice by increasing osteoclastogenesis., PMID:29055830
Cherubism Mice Also Deficient in c-Fos Exhibit Inflammatory Bone Destruction Executed by Macrophages That Express MMP14 Despite the Absence of TRAP+ Osteoclasts., PMID:28914985
Syk-dependent tyrosine phosphorylation of 3BP2 is required for optimal FcRγ-mediated phagocytosis and chemokine expression in U937 cells., PMID:28904407
For research use only. Not for human or drug use.
