Catalog No.
YHF09501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu15-Val87
Predicted molecular weight
34.39 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P55085
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
GPR11, Thrombin receptor-like 1, G-protein coupled receptor 11, F2RL1, PAR-2, Coagulation factor II receptor-like 1, Proteinase-activated receptor 2, PAR2
Mast cell tryptase-PAR2 axis promotes ovarian fibrosis through RNF152-mediated stabilization of Bcl-xL., PMID:40474218
Structural basis for the activation of proteinase-activated receptors PAR1 and PAR2., PMID:40287415
Neutrophil-derived serine proteases induce FOXA2-mediated autophagy dysfunction and exacerbate colitis-associated carcinogenesis via protease activated receptor 2., PMID:40205686
PAR2 deficiency impairs antitumor immunity and attenuates anti-PD1 efficacy in colorectal cancer., PMID:40174816
PAR2 Serves an Indispensable Role in Controlling PAR4 Oncogenicity: The β-Catenin-p53 Axis., PMID:40141421
Protease-activated receptor-2 (PAR2) mutation attenuates airway fibrosis in mice during the exacerbation of house dust mite‑induced allergic lung disease by multi‑walled carbon nanotubes., PMID:40057754
Non-classical neutrophil extracellular traps induced by PAR2-signaling proteases., PMID:39971938
Bioinformatics and experimental insights into F2RL1 as a key biomarker in cervical cancer diagnosis and prognosis., PMID:39939734
Integrin α1 upregulation by TF:FVIIa complex promotes cervical cancer migration through PAR2-dependent MEK1/2 activation., PMID:39657349
House dust mites stimulate thymic stromal lymphopoietin production in human bronchial epithelial cells and promote airway remodeling through activation of PAR2 and ERK signaling pathway., PMID:39562597
Protease activated receptor 2 deficiency retards progression of abdominal aortic aneurysms by modulating phenotypic transformation of vascular smooth muscle cells via ERK signaling., PMID:39490888
Protease activated receptor 2 as a novel druggable target for the treatment of metabolic dysfunction-associated fatty liver disease and cancer., PMID:39464875
PAR2 on oral cancer cells and nociceptors contributes to oral cancer pain that can be relieved by nanoparticle-encapsulated AZ3451., PMID:39418848
The role of PAR2 in regulating MIF release in house dust mite-induced atopic dermatitis., PMID:39416784
Targeting PAR2-mediated inflammation in osteoarthritis: a comprehensive in vitro evaluation of oleocanthal's potential as a functional food intervention for chondrocyte protection and anti-inflammatory effects., PMID:39354427
Protease-Activated Receptor 2 in inflammatory skin disease: current evidence and future perspectives., PMID:39301020
Proteolytic bacteria expansion during colitis amplifies inflammation through cleavage of the external domain of PAR2., PMID:39171684
FXa-mediated PAR-2 promotes the efficacy of immunotherapy for hepatocellular carcinoma through immune escape and anoikis resistance by inducing PD-L1 transcription., PMID:39060025
Exogenous autoinducer-2 alleviates intestinal damage in necrotizing enterocolitis via PAR2/MMP3 signaling pathway., PMID:38950458
Airway epithelial overexpressed cathepsin K induces airway remodelling through epithelial-mesenchymal trophic unit activation in asthma., PMID:38853468
PAR2-mediated cellular senescence promotes inflammation and fibrosis in aging and chronic kidney disease., PMID:38687090
Controlling autoimmune diabetes onset by targeting Protease-Activated Receptor 2., PMID:38653114
Protective role of protease-activated receptor-2 in anaphylaxis model mice., PMID:38635782
Naringin Alleviates Intestinal Fibrosis by Inhibiting ER Stress-Induced PAR2 Activation., PMID:38557865
Protease-Induced Excitation of Dorsal Root Ganglion Neurons in Response to Acute Perturbation of the Gut Microbiota Is Associated With Visceral and Somatic Hypersensitivity., PMID:38494056
Protease-activated receptor 2 drives migration in a colon cancer cell line but not in noncancerous human epithelial cells., PMID:38440826
Neuronal BST2: A Pruritic Mediator alongside Protease-Activated Receptor 2 in the IL-27-Driven Itch Pathway., PMID:38360199
Association of single nucleotide polymorphisms in the F2RL1 gene with clinical and inflammatory characteristics of patients with asthma., PMID:38308375
Melitoxin Inhibits Proliferation, Metastasis, and Invasion of Glioma U251 Cells by Down-regulating F2RL1., PMID:38252207
Inhibition of proteinase-activated receptor 2 (PAR2) decreased the malignant progression of lung cancer cells and increased the sensitivity to chemotherapy., PMID:38172304
A novel trypsin of Trichinella spiralis mediates larval invasion of gut epithelium via binding to PAR2 and activating ERK1/2 pathway., PMID:38166153
Single-Nucleotide Polymorphisms of the PAR2 and IL-17A Genes Are Significantly Associated with Chronic Pain., PMID:38139455
An essential signaling cascade for avian auditory hair cell regeneration., PMID:38128539
Targeting class A GPCRs for hard tissue regeneration., PMID:38100905
Bcl-xL mediates interferon-beta secretion by protease-activated receptor 2 deficiency through the mitochondrial permeability transition pore in colorectal cancer metastasis., PMID:37972702
Identification and validation of novel prognostic signatures based on m5C methylation patterns and tumor EMT profiles in head and neck squamous cell carcinoma., PMID:37907576
PAR2-dependent phosphorylation of TRPV4 at the trigeminal nerve terminals contributes to tongue cancer pain., PMID:37838226
An alpha-helix variant p.Arg156Pro in LMNA as a cause of hereditary dilated cardiomyopathy: genetics and bioinfomatics exploration., PMID:37784143
Dysfunction of autophagy in high-fat diet-induced non-alcoholic fatty liver disease., PMID:37700498
Role of the protease-activated receptor-2 (PAR2) in the exacerbation of house dust mite-induced murine allergic lung disease by multi-walled carbon nanotubes., PMID:37580758
Shear Stress Drives the Cleavage Activation of Protease-Activated Receptor 2 by PRSS3/Mesotrypsin to Promote Invasion and Metastasis of Circulating Lung Cancer Cells., PMID:37395651
Integrative multiomics analysis identifies a metastasis-related gene signature and the potential oncogenic role of EZR in breast cancer., PMID:37304008
Purification and characterization of a serine protease from organic dust and elucidation of its inductive effects on lung inflammatory mediators., PMID:37253661
Unravelling the Impact of Cyclic Mechanical Stretch in Keratoconus-A Transcriptomic Profiling Study., PMID:37108600
Identifying the potential transcriptional regulatory network in Hirschsprung disease by integrated analysis of microarray datasets., PMID:37082700
Integrative transcriptomics analysis and experimental validation reveal immunomodulatory patterns in keratoconus., PMID:37001853
Inhibition of HIST1H2AB suppresses the proliferation of lung adenocarcinoma., PMID:36511295
RNF43 induces the turnover of protease-activated receptor 2 in colon cancer., PMID:36468684
Human Induced Pluripotent Stem Cell-Derived Keratinocyte-Like Cells for Research on Protease-Activated Receptor 2 in Nonhistaminergic Cascades of Atopic Dermatitis ., PMID:36351795
GPR97 triggers inflammatory processes in human neutrophils via a macromolecular complex upstream of PAR2 activation., PMID:36302784
For research use only. Not for human or drug use.
