Catalog No.
YHF05701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp375-Asn535
Predicted molecular weight
20.86 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P54803
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Galactocerebroside beta-galactosidase, GALCERase, GALC, Galactosylceramidase, Galactosylceramide beta-galactosidase, Galactocerebrosidase
Neuroglial Pathophysiology of Leukodystrophies., PMID:40500501
Quantification profiles of enzyme activity, secretion and psychosine levels of Krabbe disease galactosylceramidase missense variants., PMID:40449593
Comparative Brain and Serum Exosome Expression of Biomarkers in an Experimental Model of Alzheimer-Type Neurodegeneration: Potential Relevance to Liquid Biopsy Diagnostics., PMID:40362426
Exploring lipid metabolism-associated gene biomarkers and their regulatory mechanisms in nasopharyngeal carcinoma., PMID:40294966
STING mediates lysosomal quality control and recovery through its proton channel function and TFEB activation in lysosomal storage disorders., PMID:40185098
RBM10 deficiency promotes brain metastasis by modulating sphingolipid metabolism in a BBB model of EGFR mutant lung adenocarcinoma., PMID:40069781
Purifying selection of the lysosomal enzymes arylsulfatase A and beta-galactocerebrosidase and their evolutionary impact on myelin integrity., PMID:40054667
Natural History and Diagnostic Findings in an Adult Man Diagnosed With Attenuated Krabbe Disease., PMID:40017455
Multiomics approach identifies dysregulated lipidomic and proteomic networks in Parkinson's disease patients mutated in TMEM175., PMID:39856101
Ablation of lipocalin-2 reduces neuroinflammation in a mouse model of Krabbe disease., PMID:39738378
Human iPSC-derived myelinating organoids and globoid cells to study Krabbe disease., PMID:39636943
Haploinsufficiency of lysosomal enzyme genes in Alzheimer's disease., PMID:39605615
Expression study of Krabbe Disease GALC missense variants - Insights from quantification profiles of residual enzyme activity, secretion and psychosine levels., PMID:39464077
[Expanded carrier screening for 216 diseases in a cohort of 3 097 healthy Chinese individuals of childbearing age]., PMID:39463360
Multisite Injections of Canine Glial-Restricted Progenitors Promote Brain Myelination and Extend the Survival of Dysmyelinated Mice., PMID:39408910
Unilateral Vocal Cord Paralysis in a Patient with Anti-Galactocerebroside Antibodies: A Case Report., PMID:39231647
Human iPSC-derived myelinating organoids and globoid cells to study Krabbe Disease., PMID:39091729
Late-onset Krabbe disease presenting as spastic paraplegia - implications of GCase and CTSB/D., PMID:38837642
Perinatal loss of galactosylceramidase in both oligodendrocytes and microglia is crucial for the pathogenesis of Krabbe disease in mice., PMID:38734898
Impact of an irreversible β-galactosylceramidase inhibitor on the lipid profile of zebrafish embryos., PMID:38596316
Clinical application value of pre-pregnancy carrier screening in Chinese Han childbearing population., PMID:38562051
Proteomic Analysis Highlights the Impact of the Sphingolipid Metabolizing Enzyme β-Galactosylceramidase on Mitochondrial Plasticity in Human Melanoma., PMID:38474307
From pathological mechanisms in Krabbe disease to cutting-edge therapy: A comprehensive review., PMID:38444347
Chronic Rapamycin administration via drinking water mitigates the pathological phenotype in a Krabbe disease mouse model through autophagy activation., PMID:38422660
Transcription factor encoding gene OsC1 regulates leaf sheath color through anthocyanidin metabolism in Oryza rufipogon and Oryza sativa., PMID:38418937
The Effect of p.G2019S Mutation in the LRRK2 Gene on the Activity of Lysosomal Hydrolases and the Clinical Features of Parkinson's Disease Associated with p.N370S Mutation in the GBA1 Gene., PMID:38287861
Determination of Carrier Frequency of Actionable Pathogenic Variants in Autosomal Recessive Genetic Diseases in the Turkish Cypriot Population., PMID:37895316
Genetic assessment of pathogenic germline alterations in lysosomal genes among Asian patients with pancreatic ductal adenocarcinoma., PMID:37848935
The development of a broad-spectrum retaining β-exo-galactosidase activity-based probe., PMID:37724332
Brain Targeted AAV1-GALC Gene Therapy Reduces Psychosine and Extends Lifespan in a Mouse Model of Krabbe Disease., PMID:37628569
High genetic heterogeneity of leukodystrophies in Iranian children: the first report of Iranian Leukodystrophy Registry., PMID:37597066
The Pro-Oncogenic Sphingolipid-Metabolizing Enzyme β-Galactosylceramidase Modulates the Proteomic Landscape in BRAF(V600E)-Mutated Human Melanoma Cells., PMID:37445731
Clinical, genetic, and molecular characteristics in a central-southern Chinese cohort of genetic leukodystrophies., PMID:37434390
CD8+ T cell depletion prevents neuropathology in a mouse model of globoid cell leukodystrophy., PMID:37310382
Overexpression of OLIG2 and MYT1L Transcription Factors Enhance the Differentiation Potential of Human Mesenchymal Stem Cells into Oligodendrocytes., PMID:37232730
Revealing the roles of glycosphingolipid metabolism pathway in the development of keloid: a conjoint analysis of single-cell and machine learning., PMID:37168863
24-hydroxycholesterol replacement rate measured in blood is a non-invasive biomarker of brain demyelination and remyelination in cuprizone-treated mice., PMID:37003487
Impaired Autophagy in Krabbe Disease: The Role of BCL2 and Beclin-1 Phosphorylation., PMID:36983059
Mechanotransduction Impairment in Primary Fibroblast Model of Krabbe Disease., PMID:36979906
In silico modelling of the function of disease-related CAZymes., PMID:36912236
Biochemical Characteristics of iPSC-Derived Dopaminergic Neurons from N370S GBA Variant Carriers with and without Parkinson's Disease., PMID:36901867
27-hydroxycholesterol promotes oligodendrocyte maturation: Implications for hypercholesterolemia-associated brain white matter changes., PMID:36779429
Reliable and Fast Genotyping Protocol for Galactosylceramidase (Galc) in the Twitcher (Twi) Mouse., PMID:36551902
Identifying Genes that Affect Differentiation of Human Neural Stem Cells and Myelination of Mature Oligodendrocytes., PMID:36547781
Profound tumor response to combined CTLA-4 and PD-1 inhibition in systemic fourth line therapy observed in a patient with hepatocellular carcinoma harboring SETD2 and LRP1B mutations., PMID:36379463
GALC variants affect galactosylceramidase enzymatic activity and risk of Parkinson's disease., PMID:36370000
Neurodegenerative Disorder Risk in Krabbe Disease Carriers., PMID:36362324
Galactosylceramidase deficiency and pathological abnormalities in cerebral white matter of Krabbe disease., PMID:36113749
β-Galactosylceramidase Deficiency Causes Upregulation of Long Pentraxin-3 in the Central Nervous System of Krabbe Patients and Twitcher Mice., PMID:36012705
Involvement of Huanglian Jiedu Decoction on Microglia with Abnormal Sphingolipid Metabolism in Alzheimer's Disease., PMID:35391788
For research use only. Not for human or drug use.
