Catalog No.
YHE92801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu616-Ser849
Predicted molecular weight
29.16 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P52630
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
p113, STAT2, Signal transducer and activator of transcription 2
MYO9B deficiency promoted head and neck tumor progression through HIF1α/MYC/STAT2 signaling pathway., PMID:40518028
Black carp STAT2 enhances IRF3-mediated antiviral signaling by regulating its ubiquitination and improving its nuclear translocation., PMID:40513786
SARS-CoV-2 infection of human cortical cells is influenced by the interaction between aneuploidy and biological sex: insights from a Down syndrome in vitro model., PMID:40445428
LncRNA MALAT1 facilitates HIV-1 replication by upregulation of CHCHD2 and downregulation of IFN-I expression., PMID:40414289
The viral early protein 4 of human papillomavirus type 16 suppresses innate antiviral immunity., PMID:40409624
Cyanidin-3-O-glucoside mitigates Staphylococcus aureus-induced mastitis by suppressing inflammatory responses and Ferroptosis mediated by SESN2/Nrf2., PMID:40394793
Characterization of Mucosal Immune-Related lncRNAs and mRNAs in a Mouse Model of Allergic Conjunctivitis., PMID:40357374
OGT-regulated O-GlcNAcylation promotes the malignancy of colorectal cancer by activating STAT2 to induce macrophage M2: OGT protein macromolecule action., PMID:40348242
Design, synthesis and biological evaluation of dapsone derivatives with broad-spectrum antiviral activity., PMID:40344737
IRF5 Mediates Artery Inflammation in Salt-Sensitive Hypertension by Regulating STAT1 and STAT2 Phosphorylation to Increase ESM1 Transcription: Insights from Bioinformatics and Mechanistic Analysis., PMID:40332339
Human papillomavirus E1 proteins inhibit RIG-I/MDA5-MAVS, TLR3-TRIF, cGAS-STING, and JAK-STAT signaling pathways to evade innate antiviral immunity., PMID:40330484
RBM39 shapes innate immunity by controlling the expression of key factors of the interferon response., PMID:40330464
Portulaca oleracea L. Extract and Its Alkaloid Oleracein E Alleviates Cardiac Remodeling and Heart Failure in Mice by Targeting STAT2 Through the MAPK Signaling Inflammatory Pathway., PMID:40289247
Chasing Virus Replication and Infection: PAMP-PRR Interaction Drives Type I Interferon Production, Which in Turn Activates ISG Expression and ISGylation., PMID:40284971
USP5 motivates immunosuppressive microenvironment in multiple myeloma by activating STAT2-PFKFB4-mediated glycolysis., PMID:40274624
Human papillomavirus E2 proteins suppress innate antiviral signaling pathways., PMID:40264759
Inhibition of miRNA-365-2-5p Targeting SIRT1 Regulates Functions of Keratinocytes to Enhance Wound Healing., PMID:40261275
Type I Interferon-Induced Modification of Yellow Fever Virus NS5 Enhances Binding to Human STAT2., PMID:40249426
Papaverine Targets STAT Signaling: A Dual-Action Therapy Option Against SARS-CoV-2., PMID:40171981
Unravelling Cancer Immunity: Coagulation.Sig and BIRC2 as Predictive Immunotherapeutic Architects., PMID:40159652
CMTM4 promotes PD-L1-mediated macrophage apoptosis by enhancing STAT2 phosphorylation in sepsis., PMID:40122504
The alpha-coronavirus E protein inhibits the JAK-STAT pathway signaling by triggering STAT2 degradation through OPTN- and NBR1-mediated selective autophagy., PMID:40091174
Discovering new hub genes of dilated cardiomyopathy., PMID:40074718
Mpox virus poxin-schlafen fusion protein suppresses innate antiviral response by sequestering STAT2., PMID:40066622
Identification of a novel non-coding deletion in Allan-Herndon-Dudley syndrome by long-read HiFi genome sequencing., PMID:40033291
Omics Investigations of Prostate Cancer Cells Exposed to Simulated Microgravity Conditions., PMID:40001606
Cytoplasmic Shift of Interferon Regulatory Factors Co-Evolved With Jawed Vertebrate Innate Immunity., PMID:39977406
Integrating bulk RNA-seq and scRNA-seq data to explore diverse cell death patterns and develop a programmed cell death-related relapse prediction model in pediatric B-ALL., PMID:39955305
Bioinformatic analysis and experimental validation implicate STAT2-mediated angiogenic responses in rosacea pathogenesis., PMID:39945902
An immunocompetent mouse model revealed that congenital Zika virus infection disrupted hippocampal function by activating autophagy., PMID:39945741
Transcriptome and DNA methylation analyses provide insight into the heterosis of growth-related traits in hybrid yellow croaker., PMID:39939943
Borrelia burgdorferi sensu lato inhibits CIITA transcription through pSTAT3 activation and enhanced SOCS1 and SOCS3 expression leading to limited IFN-γ production., PMID:39879745
Transcriptional signature of CD56bright NK cells predicts favourable prognosis in bladder cancer., PMID:39877370
CD209d/e promotes inflammation and lung injury during influenza virus infection., PMID:39846844
Glycine Decarboxylase Regulates Renal Carcinoma Progression via Interferon Stimulated Gene Factor 3-Mediated Pathway., PMID:39781465
Cannabichromene as a Novel Inhibitor of Th2 Cytokine and JAK/STAT Pathway Activation in Atopic Dermatitis Models., PMID:39769302
LTBP2 silence suppresses glioblastoma proliferation and tumor growth of xenograft tumor mice through modulating JAK2/STAT2 signaling pathway., PMID:39752891
α7-Nicotinic Acetylcholine Receptor Activation Modulates BV2 Microglial Plasticity via miR-21/TNF-α/NFκB in Oxygen-Glucose Deprivation/Reoxygenation., PMID:39718716
SARS-CoV-2 S protein disrupts the formation of ISGF3 complex through conserved S2 subunit to antagonize type I interferon response., PMID:39699185
The segmented flavivirus Alongshan virus reduces mitochondrial mass by degrading STAT2 to suppress the innate immune response., PMID:39655955
Association study of the JAK/STAT signaling pathway with susceptibility to COVID-19 in moroccan patient and in-silico analysis of rare variants., PMID:39647533
Indirect targeting of MYC and direct targeting in combination with chemotherapies are more effective than direct mono-targeting in triple negative breast cancer., PMID:39631207
Coronavirus nucleocapsid protein enhances the binding of p-PKCα to RACK1: Implications for inhibition of nucleocytoplasmic trafficking and suppression of the innate immune response., PMID:39602452
STAT2/SLC27A3/PINK1-Mediated Mitophagy Remodeling Lipid Metabolism Contributes to Pazopanib Resistance in Clear Cell Renal Cell Carcinoma., PMID:39600540
ZNF350 gene polymorphisms promote the response to Peg-IFNα therapy through JAK-STAT signaling pathway in patients with chronic hepatitis B., PMID:39575240
Cell-integrated serum-induced signalling patterns can differentiate between hand and knee osteoarthritis patients., PMID:39558621
Proteome modulation triggers potent antiviral response in Japanese Encephalitis Virus infected human macrophages., PMID:39520552
PARP7i Clinical Candidate RBN-2397 Exerts Antiviral Activity by Modulating Interferon-β Associated Innate Immune Response in Macrophages., PMID:39503161
A CRISPR-Cas9 knockout screening identifies IRF2 as a key driver of OAS3/RNase L-mediated RNA decay during viral infection., PMID:39475651
LGR6 protects against myocardial ischemia-reperfusion injury via suppressing necroptosis., PMID:39471639
For research use only. Not for human or drug use.
