Catalog No.
YHE22301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gln19-Val83
Predicted molecular weight
9.81 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P38398
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
BRCA1, Breast cancer type 1 susceptibility protein, RING-type E3 ubiquitin transferase BRCA1, RING finger protein 53, RNF53
Personalized Treatment in Ovarian Cancer: A Review of Disease Monitoring, Biomarker Expression, and Targeted Treatments for Advanced, Recurrent Ovarian Cancers., PMID:40507303
DNA damage response inhibition is an early event in cadmium-induced breast carcinogenesis., PMID:40505819
In silico screening, ADMET analysis and computational simulation studies on Garcinia indica Choisy phytoconstituents as prospective antibreast cancer agents: a critical appraisal of the neglected plant., PMID:40487787
New twist on BRCA1-mediated DNA recombination repair and tumor suppression., PMID:40480845
Adaptation of PCR-based library preparation for MGI platform for cancer mutation testing in clinical setting., PMID:40465654
High prevalence of constitutional BRCA1 epimutation in patients with early-onset triple-negative breast cancer., PMID:40462235
Kaiso mediates transcription and RNA splicing in colorectal carcinoma: role of BRCA1 in the Kaiso enhanceosome., PMID:40460875
Stomatobaculum longum-Derived Extracellular Vesicles Enhance Oral Squamous Cell Carcinoma Malignancy Through BRCA1/EXO1/TP53BP1 Modulation., PMID:40452786
Structural basis of Fanconi anemia pathway activation by FANCM., PMID:40447800
Quality of life after risk reducing mastectomy in a Portuguese cohort of BRCA pathogenic/likely pathogenic variant carriers., PMID:40445415
Integrating metabolomics and transcriptomics to analyze differences in muscle mass and flavor formation in Gayal and yellow cattle., PMID:40438416
Different Mechanisms in Doxorubicin-Induced Neurotoxicity: Impact of BRCA Mutations., PMID:40429877
Proteomic Analysis of Invasive Breast Cancer Cells Treated with CBD Reveals Proteins Associated with the Reversal of Their Epithelial-Mesenchymal Transition Induced by IL-1β., PMID:40429863
Real-World Analysis of HRD Assay Variability in High-Grade Serous Ovarian Cancer: Impacts of BRCA1/2 Mutation Subtypes on HRD Assessment., PMID:40427638
Treatment Patterns, Clinical Outcomes and Quality of Life in BRCA1/2-Associated Breast Cancer Patients: A Retrospective Analysis., PMID:40422528
Cancer Vulnerabilities Through Targeting the ATR/Chk1 and ATM/Chk2 Axes in the Context of DNA Damage., PMID:40422251
Ultrasensitive Analysis of BRCA-1 Based on Gold Nanoparticles and Molybdenum Disulfide Electrochemical Immunosensor with Enhanced Signal Amplification., PMID:40422069
5'UTR gene regions in germline DNA sequencing panels: lessons from the analysis of breast and ovarian cancer patients of Tatar and Bashkir ethnic origin., PMID:40419811
[Association analysis on BRCA gene functional domain mutations and prognosis in patients with ovarian epithelial carcinoma and fallopian tube carcinoma]., PMID:40419351
Detection rates of multigene panel and exome testing in patients with previous negative BRCA1/2 results., PMID:40418377
Evaluation of aggrephagy markers in myofibrillar myopathies., PMID:40413523
Analysis of more than 400,000 women provides case-control evidence for BRCA1 and BRCA2 variant classification., PMID:40413188
MePCE promotes homologous recombination through coordinating R-loop resolution at DNA double-stranded breaks., PMID:40411785
Timely germline BRCA testing after invasive breast cancer promotes contralateral risk-reducing mastectomy and improves survival: an observational retrospective study., PMID:40408052
Unraveling SET: Exploring ovarian high-grade serous carcinoma and its BRCA1/2 immunoexpression., PMID:40405589
Impact of germline BRCA1/2 mutations on response to neoadjuvant systemic therapy and prognosis in breast cancer: a propensity score matched cohort study., PMID:40405286
Identifying the germline variation spectrum and predisposition genes in Chinese ovarian cancer using whole exome sequencing., PMID:40405108
CTC1-STN1-TEN1 controls DNA break repair pathway choice via DNA end resection blockade., PMID:40403056
Identification of novel gene expression patterns and pathways involved in PARP-1 inhibitor resistance., PMID:40402278
Distribution of age at natural menopause, age at menarche, menstrual cycle length, height and BMI in BRCA1 and BRCA2 pathogenic variant carriers and non-carriers: results from EMBRACE., PMID:40399999
Olaparib Monotherapy or in Combination with Abiraterone for the Treatment of Patients with Metastatic Castration-Resistant Prostate Cancer (mCRPC) and a BRCA Mutation., PMID:40397306
PKMYT1 kinase ameliorates cisplatin sensitivity in osteosarcoma., PMID:40393983
Predicting the likelihood of carrying BRCA1 or BRCA2 pathogenic variants in high-risk Pakistani breast cancer patients., PMID:40392478
Preliminary study of apatinib combined with fluzoparib in the treatment of HRP ovarian cancer via the HR pathway., PMID:40386258
Contralateral breast cancer in patients carrying mutations in the BRCA1∕2 gene., PMID:40384197
CD105+ fibroblasts support an immunosuppressive niche in women at high risk of breast cancer initiation., PMID:40375322
A Multi-Level Analysis of Barriers and Promoting Factors to Cascade Screening Uptake Among Male Relatives of BRCA1/2 Carriers: A Qualitative Study., PMID:40374330
Hotspot BRCA1/2 Mutations in Tumors With Microsatellite Instability Suggest Passenger Mutation Status and Evaluation of Therapeutic Options., PMID:40373258
Combining STING Agonists with PARP Inhibitors Mounts an NK-Dependent Defense against Therapy-Resistant Breast Cancer., PMID:40370063
Long-Term Oncologic Outcome of Breast-Conserving Treatment in Patients With Breast Cancer With BRCA Variants., PMID:40366658
CA125 Serum Levels in BRCA1/BRCA2 Pathogenic Sequence Variant Carriers as an Ovarian Cancer Screening Tool: A Longitudinal Study., PMID:40365969
Molecular Mechanisms of Tumor Progression and Novel Therapeutic and Diagnostic Strategies in Mesothelioma., PMID:40362535
Factors affecting the implementation of cascade testing of patients with BRCA1 or BRCA2 pathogenic germline variants in Japan., PMID:40361302
Neoadjuvant PARP inhibitor scheduling in BRCA1 and BRCA2 related breast cancer: PARTNER, a randomized phase II/III trial., PMID:40360463
Cytoreductive surgery in advanced epithelial ovarian cancer: a real-world analysis guided by clinical variables, homologous recombination, and BRCA status., PMID:40359671
Clinical aspect of male breast cancer: a burgeoning and unaddressed issue., PMID:40358767
BRCA1 influences whole body metabolism in humanized mice., PMID:40353614
Long-term health outcomes of bilateral salpingo-oophorectomy in BRCA1 and BRCA2 pathogenic variant carriers with personal history of breast cancer: a retrospective cohort study using linked electronic health records., PMID:40347974
Association between risk-reducing surgeries and survival in young BRCA carriers with breast cancer: an international cohort study., PMID:40347973
Stronger preference of human tumor suppressor protein BRCA1 for an open-planar Holliday junction: Insights from a combined spectroscopic and computational study., PMID:40345299
For research use only. Not for human or drug use.
