Catalog No.
YHE86301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg62-Phe202
Predicted molecular weight
18.58 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P51693
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
APLP-1, APLP, Amyloid-like protein 1, APLP1
Assessing Plasma APLP1 for the Progression of Parkinson's Disease: Insights from HSPD and PPMI Cohorts., PMID:39968922
Molecular insights into myelomeningocele via proteomic analysis of amniotic fluid., PMID:39778765
Blood-derived APLP1+ extracellular vesicles are potential biomarkers for the early diagnosis of brain diseases., PMID:39742488
Familial Alzheimer's disease mutations in amyloid precursor protein impair calcineurin signaling to NMDA receptors., PMID:39732167
Serum proteome profiling of plateau acclimatization in men using Olink proteomics approach., PMID:39725655
SARS-CoV-2 and HSV-1 Induce Amyloid Aggregation in Human CSF Resulting in Drastic Soluble Protein Depletion., PMID:39510798
Identification of brain-enriched proteins in CSF as biomarkers of relapsing remitting multiple sclerosis., PMID:38880880
Aplp1 interacts with Lag3 to facilitate transmission of pathologic α-synuclein., PMID:38821932
Fine-Tuning Amyloid Precursor Protein Expression through Nonsense-Mediated mRNA Decay., PMID:38789273
VGLUT2 and APP family: unraveling the neurobiochemical mechanisms of neurostimulation therapy to STZ-induced diabetes and neuropathy., PMID:38370359
Secretome Analyses Identify FKBP4 as a GBA1-Associated Protein in CSF and iPS Cells from Parkinson's Disease Patients with GBA1 Mutations., PMID:38203854
Implication of Amyloid Precursor-like Protein 2 Expression in Cutaneous Squamous Cell Carcinoma Pathogenesis., PMID:38148084
APP family member dimeric complexes are formed predominantly in synaptic compartments., PMID:37533067
Comparative binding analysis of WGX50 and Alpha-M with APP family proteins APLP1 and APLP2 using structural-dynamics and free energy calculation approaches., PMID:37199163
m6A RNA methylation modification is involved in the disease course of heart failure., PMID:36943073
APLP2 is predominantly cleaved by β-secretase and γ-secretase in the human brain., PMID:36691315
Reduced expression of APLP2 in spinal GABAergic inhibitory neurons contributed to nerve injury-induced microglial activation and pain sensitization., PMID:36442651
Lack of APLP1 leads to subtle alterations in neuronal morphology but does not affect learning and memory., PMID:36385765
Trans-ancestry, Bayesian meta-analysis discovers 20 novel risk loci for inflammatory bowel disease in an African American, East Asian and European cohort., PMID:36308435
Exploring differential exon usage via short- and long-read RNA sequencing strategies., PMID:36168804
Encephalomalacia/gliosis, deep venous thrombosis, and cancer in Arg393His antithrombin Hanoi and the potential impact of the β-amyloid precursor protein (APP) on thrombosis and cancer., PMID:35860682
Finding New Ways How to Control BACE1., PMID:35305135
Regulation of gene expression by the APP family in the adult cerebral cortex., PMID:34997052
Common genetic signatures of Alzheimer's disease in Down Syndrome., PMID:33633844
Sex-dependent effects of amyloid precursor-like protein 2 in the SOD1-G37R transgenic mouse model of MND., PMID:34476545
Mechanistic basis for receptor-mediated pathological α-synuclein fibril cell-to-cell transmission in Parkinson's disease., PMID:34172566
Molecular Characteristics of Amyloid Precursor Protein (APP) and Its Effects in Cancer., PMID:34066808
Rapid evolution of mammalian APLP1 as a synaptic adhesion molecule., PMID:34050225
Loss of all three APP family members during development impairs synaptic function and plasticity, disrupts learning, and causes an autism-like phenotype., PMID:34008862
Tau and other proteins found in Alzheimer's disease spinal fluid are linked to retromer-mediated endosomal traffic in mice and humans., PMID:33239387
Systematic elucidation of neuron-astrocyte interaction in models of amyotrophic lateral sclerosis using multi-modal integrated bioinformatics workflow., PMID:33149111
APP Family Regulates Neuronal Excitability and Synaptic Plasticity but Not Neuronal Survival., PMID:32891188
Mutation in Sodium-Glucose Cotransporter 2 Results in Down-Regulation of Amyloid Beta (A4) Precursor-Like Protein 1 in Young Age, Which May Lead to Poor Memory Retention in Old Age., PMID:32759773
Matriptase processing of APLP1 ectodomain alters its homodimerization., PMID:32572095
The amyloid precursor protein affects glyceraldehyde 3-phosphate dehydrogenase levels, organelle localisation and thermal stability., PMID:32152789
Liquid biopsy of cerebrospinal fluid identifies neuronal pentraxin receptor (NPTXR) as a biomarker of progression of Alzheimer's disease., PMID:31415236
Copper and zinc ions govern the trans-directed dimerization of APP family members in multiple ways., PMID:31063592
Fluorescence resonance energy transfer links membrane ferroportin, hephaestin but not ferroportin, amyloid precursor protein complex with iron efflux., PMID:30647129
The crystal structure of amyloid precursor-like protein 2 E2 domain completes the amyloid precursor protein family., PMID:30608876
A Fluorescence Fluctuation Spectroscopy Assay of Protein-Protein Interactions at Cell-Cell Contacts., PMID:30582596
Analysis of Motor Function in Amyloid Precursor-Like Protein 2 Knockout Mice: The Effects of Ageing and Sex., PMID:30362021
Amyloid Precursor Protein Is Associated with Aggressive Behavior in Nonluminal Breast Cancers., PMID:30108157
Click Chemistry-mediated Biotinylation Reveals a Function for the Protease BACE1 in Modulating the Neuronal Surface Glycoproteome., PMID:29716987
Brain-related proteins as potential CSF biomarkers of Alzheimer's disease: A targeted mass spectrometry approach., PMID:29684683
APLP1 is endoproteolytically cleaved by γ-secretase without previous ectodomain shedding., PMID:29382944
Direct evidence of amyloid precursor-like protein 1 trans interactions in cell-cell adhesion platforms investigated via fluorescence fluctuation spectroscopy., PMID:29021345
Altered spontaneous brain activity pattern in cognitively normal young adults carrying mutations of APP, presenilin-1/2 and APOE ε4., PMID:28987665
Amyloid-precursor Like Proteins APLP1 and APLP2 Are Dispensable for Normal Development of the Neonatal Respiratory Network., PMID:28690498
Inactivation of γ-secretases leads to accumulation of substrates and non-Alzheimer neurodegeneration., PMID:28588032
Amyloid precursor like protein-1 promotes JNK-mediated cell migration in Drosophila., PMID:28537903
For research use only. Not for human or drug use.
