Catalog No.
YHE33401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ile375-Val596
Predicted molecular weight
27.56 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P41743
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Protein kinase C iota type, nPKC-iota, PRKCI, DXS1179E, aPKC-lambda/iota, Atypical protein kinase C-lambda/iota, PRKC-lambda/iota
Has_circRNA_0122683 (circ-PRKCI) relieves ferroptosis of HPAEpiCs in sepsis-induced acute lung injury by sponging miR-382-5p., PMID:40386233
Prkci promotes colorectal cancer metastasis by phosphorylating and stabilizing Tgfbr1 to activate TGF-β signaling., PMID:40382656
Proteasome Inhibitor MG-132 and PKC-ι-Specific Inhibitor ICA-1S Degrade Mutant p53 and Induce Apoptosis in Ovarian Cancer Cell Lines., PMID:40243672
Unravelling the role of PRKCI and key-cancer related genes in breast cancer development and metastasis., PMID:40100546
MK886 ameliorates Alzheimer's disease by activating the PRKCI/AKT signaling pathway., PMID:39922422
Protein kinase C iota (PKCι) and pVHL are both needed for lysosomal degradation of α5 integrin in renal carcinoma cells., PMID:39883230
Rare variants in PRKCI cause Van der Woude syndrome and other features of peridermopathy., PMID:39867391
Capture, mutual inhibition and release mechanism for aPKC-Par6 and its multisite polarity substrate Lgl., PMID:39762628
Cell polarity proteins promote macropinocytosis in response to metabolic stress., PMID:39627191
miR-630 as a therapeutic target in pancreatic cancer stem cells: modulation of the PRKCI-Hedgehog signaling axis., PMID:39529141
Protein kinase C iota promotes glycolysis via PI3K/AKT/mTOR signalling in high grade serous ovarian cancer., PMID:39276277
Prenatal opioid exposure significantly impacts placental protein kinase C (PKC) and drug transporters, leading to drug resistance and neonatal opioid withdrawal syndrome., PMID:39238930
Downregulation of PRKCI inhibits osteosarcoma cell growth by inactivating the Akt/mTOR signaling pathway., PMID:39015499
Epithelial aPKC deficiency leads to stem cell loss preceding metaplasia in colorectal cancer initiation., PMID:38815584
Molecular characteristics of early-onset compared with late-onset colorectal cancer: a case controlled study., PMID:38742845
Possible prognostic impact of PKCι genetic variants in prostate cancer., PMID:38200472
Enhanced SREBP2-driven cholesterol biosynthesis by PKCλ/ι deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis., PMID:38092754
Circ_0067934: a circular RNA with roles in human cancer., PMID:37592109
Investigating pathogenic SNP of PKCι in HCV-induced hepatocellular carcinoma., PMID:37532886
The diagnostic significance of the ZNF gene family in pancreatic cancer: a bioinformatics and experimental study., PMID:37396042
Echinochrome A Prevents Diabetic Nephropathy by Inhibiting the PKC-Iota Pathway and Enhancing Renal Mitochondrial Function in db/db Mice., PMID:37103361
Paired protein kinases PRKCI-RIPK2 promote pancreatic cancer growth and metastasis via enhancing NF-κB/JNK/ERK phosphorylation., PMID:37016317
Investigation of UTR Variants by Computational Approaches Reveal Their Functional Significance in PRKCI Gene Regulation., PMID:36833174
Protein kinase Cι mediates immunosuppression in lung adenocarcinoma., PMID:36383684
Genomic Features of Organ-Specific Metastases in Lung Adenocarcinoma., PMID:35912232
Upregulation of OASIS/CREB3L1 in podocytes contributes to the disturbance of kidney homeostasis., PMID:35869269
PKCι Is a Promising Prognosis Biomarker and Therapeutic Target for Pancreatic Cancer., PMID:35785767
PRKCI Mediates Radiosensitivity via the Hedgehog/GLI1 Pathway in Cervical Cancer., PMID:35785194
Identification of Arhgef12 and Prkci as genetic modifiers of retinal dysplasia in the Crb1rd8 mouse model., PMID:35675330
Deficiency of PKCλ/ι alleviates the liver pathologic impairment of Schistosoma japonicum infection by thwarting Th2 response., PMID:35505421
Impact of deleterious missense PRKCI variants on structural and functional dynamics of protein., PMID:35260606
Pan-Cancer Study on Protein Kinase C Family as a Potential Biomarker for the Tumors Immune Landscape and the Response to Immunotherapy., PMID:35174160
Prkci Regulates Autophagy and Pancreatic Tumorigenesis in Mice., PMID:35159064
Human placenta and trophoblasts simultaneously express three isoforms of atypical protein kinase-c., PMID:35124330
Protein phosphatase 1 regulatory inhibitor subunit 14C promotes triple-negative breast cancer progression via sustaining inactive glycogen synthase kinase 3 beta., PMID:35090098
Altered Expression of Par3, aPKC-λ, and Lgl1 in Hippocampus in Kainic Acid-Induced Status Epilepticus Rat Model., PMID:34956060
Control of β-Site Amyloid Precursor Protein-Cleaving Enzyme-1 Expression by Protein Kinase C-λ/ι and Nuclear Factor κ-B., PMID:34951366
Immunosurveillance, interferon, and autophagic networking in cancer: the PRKCI-ULK2 paradigm., PMID:34895031
GLO 1 and PKCλ Regulate ALDH1-positive Breast Cancer Stem Cell Survival., PMID:34848450
ELF3 Is a Target That Promotes Therapeutic Efficiency in EGFR Tyrosine Kinase Inhibitor-Resistant Non-Small Cell Lung Cancer Cells via Inhibiting PKCί., PMID:34830169
Protein kinase Cι and SRC signaling define reciprocally related subgroups of glioblastoma with distinct therapeutic vulnerabilities., PMID:34818553
Hepatocyte polarity establishment and apical lumen formation are organized by Par3, Cdc42, and aPKC in conjunction with Lgl., PMID:34717957
PKCλ/ι inhibition activates an ULK2-mediated interferon response to repress tumorigenesis., PMID:34560002
The vitellogenin receptor functionality of the migratory locust depends on its phosphorylation by juvenile hormone., PMID:34493670
Comprehensive molecular profiling to predict clinical outcomes in pancreatic cancer., PMID:34471425
Driver and novel genes correlated with metastasis of non-small cell lung cancer: A comprehensive analysis., PMID:34298439
Circ-PRKCI Alleviates Lipopolysaccharide-induced Human Kidney 2 Cell Injury by Regulating miR-106b-5p/GAB1 Axis., PMID:34269703
A Panel-Based Sequencing Analysis of Patients with Paget's Disease of Bone Suggests Enrichment of Rare Genetic Variation in regulators of NF-κB Signaling and Supports the Importance of the 7q33 Locus., PMID:34173013
circ-PRKCI targets miR-1294 and miR-186-5p by downregulating FOXK1 expression to suppress glycolysis in hepatocellular carcinoma., PMID:33880589
New Therapeutic Opportunities for the Treatment of Squamous Cell Carcinomas: A Focus on Novel Driver Kinases., PMID:33799513
For research use only. Not for human or drug use.
