Catalog No.
YHE81901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp2-Cys129
Predicted molecular weight
16.42 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P51460
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Ley-I-L, RLNL, Insulin-like 3, Relaxin-like factor, RLF, Leydig insulin-like peptide, INSL3
Defining the end of puberty in boys: INSL3 and the acute determinants of adult Leydig-cell functional capacity., PMID:40496564
Molecular mechanism underlying non-discriminatory recognition of relaxin-3 by RXFP3 and RXFP4., PMID:40410443
Effects of INSL3 and WNT2B gene polymorphisms on seasonal reproductive traits of Xinjiang Qira black sheep, Kazakh sheep and Duolang sheep., PMID:40317716
Foetal Exposure to Phthalates and Endocrine Effects on the Leydig Cell., PMID:40205816
Relief of loperamide-induced constipation by peptidic and small molecule RXFP4 agonists in mice., PMID:40194608
INSL3 promotes macrophage polarization to an immunosuppressive phenotype via the cAMP downstream signaling pathway and Akt/mTOR pathway., PMID:40168802
Potential ability of circulating INSL3 level for the prediction of ovarian reserve and IVF success as a novel theca cell-specific biomarker in women with unexplained infertility and diminished ovarian reserve., PMID:40082934
A New Leydig Cell-Exclusive Cre Line Allows Lineage Tracing of Fetal and Adult Leydig Cell Populations in the Mouse., PMID:39823408
Spermatic RXFP2 expression levels and seminal INSL3 concentrations among beef bull ejaculates with different levels of sperm morphological normality., PMID:39721672
Engineering of Novel Analogues That Are More Receptor-Selective and Potent than the Native Hormone, Insulin-like Peptide 5 (INSL5)., PMID:39568362
Exploring Testicular Descent: Recent Findings and Future Prospects in Canine Cryptorchidism., PMID:39504939
Anti-Inflammatory effect of INSL-3 on experimental arthritis model and LPS-induced macrophage cell line., PMID:39442190
Biallelic RXFP2 variants lead to congenital bilateral cryptorchidism and male infertility, supporting a role of RXFP2 in spermatogenesis., PMID:39222519
Serum INSL3 measured by LC-MS/MS in pubertal girls and in girls with precocious puberty during GnRH agonist treatment., PMID:39010900
Expression of Insl3 Protein in Adult Danio rerio., PMID:38791457
Developing insulin-like peptide 5-based antagonists for the G protein-coupled receptor, RXFP4., PMID:38679208
Development of a synthetic relaxin-3/INSL5 chimeric peptide ligand for NanoBiT complementation binding assays., PMID:38677442
Insulin-like peptide 3 (INSL3) as an indicator of leydig cell insufficiency (LCI) in Middle-aged and older men with hypogonadism: reference range and threshold., PMID:38676285
Maternal Fed Zinc-Deficient Diet: Effects on Relaxin Family Peptides and Oxidant System in the Testis and Liver Tissue of Male Offspring., PMID:38407794
New JAK3-INSL3 Fusion Transcript-An Oncogenic Event in Cutaneous T-Cell Lymphoma., PMID:37830594
The impact of acute SARS-CoV-2 on testicular function including insulin-like factor 3 (INSL3) in men with mild COVID-19: A longitudinal study., PMID:37421657
Serum Insulin-like Factor 3, Testosterone, and LH in Experimental and Therapeutic Testicular Suppression., PMID:37235781
Bi-allelic variants in INSL3 and RXFP2 cause bilateral cryptorchidism and male infertility., PMID:37208861
Insulin-like peptide 5 is associated with insulin resistance in women with polycystic ovary syndrome., PMID:37207506
The RXFP2-PLC/PKC signaling pathway mediates INSL3-induced regulation of the proliferation, migration and apoptosis of mouse gubernacular cells., PMID:36849880
A 35-bp Conserved Region Is Crucial for Insl3 Promoter Activity in Mouse MA-10 Leydig Cells., PMID:36499388
Insulin-like peptide 5 (INSL5) positively correlates with anti-Müllerian hormone (AMH) in women with the polycystic ovary syndrome: a case-control study., PMID:36303231
Chicken ovalbumin upstream promoter transcription factor type II interacts and functionally cooperates with GATA4 to regulate anti-Müllerian hormone receptor type 2 transcription in mouse MA-10 Leydig cells., PMID:35973717
The nuclear receptors SF1 and COUP-TFII cooperate on the Insl3 promoter in Leydig cells., PMID:35666805
Expression and Role of INSL3 in the Fetal Testis., PMID:35464060
Isolated cryptorchidism in dogs is not associated with polymorphisms of the INSL3 and AR candidate genes., PMID:35080026
Expression of Cytokine-Coding Genes BMP8B, LEFTY1 and INSL5 Could Distinguish between Ulcerative Colitis and Crohn's Disease., PMID:34680872
Anti-Müllerian hormone, testosterone, and insulin-like peptide 3 as biomarkers of Sertoli and Leydig cell function during deslorelin-induced testicular downregulation in the dog., PMID:34534687
Serum Concentrations and Gonadal Expression of INSL3 in Eighteen Males With 45,X/46,XY Mosaicism., PMID:34447353
Identification and verification of HCAR3 and INSL5 as new potential therapeutic targets of colorectal cancer., PMID:34419055
Association of antimullerian hormone with the size of the appendix testis, the androgen and estrogen receptors and their expression in the appendix testis, in congenital cryptorchidism., PMID:34265880
Clinical value of INSL3 in the diagnosis and development of diabetic nephropathy., PMID:34233048
The flavonoid, kaempferol-3-O-apiofuranosyl-7-O-rhamnopyranosyl, as a potential therapeutic agent for breast cancer with a promoting effect on ovarian function., PMID:33908658
Male seminal parameters are not associated with Leydig cell functional capacity in men., PMID:33715296
Evidence for existence of insulin-like factor 3 (INSL3) hormone-receptor system in the ovarian corpus luteum and extra-ovarian reproductive organs during pregnancy in goats., PMID:33590284
Insulin-like 3 affects zebrafish spermatogenic cells directly and via Sertoli cells., PMID:33589679
Tumour-derived Dilp8/INSL3 induces cancer anorexia by regulating feeding neuropeptides via Lgr3/8 in the brain., PMID:33558728
Diabetes Type 1 Negatively Influences Leydig Cell Function in Rats, Which is Partially Reversible By Insulin Treatment., PMID:33507237
Age-related changes in human Leydig cell status., PMID:33094328
New theca-cell marker insulin-like factor 3 is associated with premature ovarian insufficiency., PMID:33041054
Mass Spectrometry Supports That the Structure of Circulating Human Insulin-Like Factor 3 Is a Heterodimer., PMID:32982964
INSL3: A Marker of Leydig Cell Function and Testis-Bone-Skeletal Muscle Network., PMID:32981493
The G178A polymorphic variant of INSL3 may be linked to cryptorchidism among Egyptian pediatric cohort., PMID:32865613
Diverse functions of insulin-like 3 peptide., PMID:32813485
Longitudinal Increases in Serum Insulin-like Factor 3 and Testosterone Determined by LC-MS/MS in Pubertal Danish Boys., PMID:32761207
For research use only. Not for human or drug use.
