Catalog No.
YHE55201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala68-Cys303
Predicted molecular weight
29.22 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P48059
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PINCH, Renal carcinoma antigen NY-REN-48, PINCH1, LIM and senescent cell antigen-like-containing domain protein 1, LIMS1, PINCH-1, Particularly interesting new Cys-His protein 1
Loss of lims1 causes aberrant cardiac remodeling and heart failure via activating gp130/Jak1/Stat3 pathway in zebrafish., PMID:40252966
PINCH-1 promotes tumor growth and metastasis by enhancing DRP1-mediated mitochondrial fission in head and neck squamous cell carcinoma., PMID:40065703
Interdependent roles for growth differentiation factor-15 (GDF15) and LIMS1 in regulating cell migration: Implications for colorectal cancer metastasis., PMID:39837390
Novel Aspects of Immunogenetics and Post-Transplant Events in Kidney Transplantation., PMID:39703873
Genomic collision at the LIMS-1 locus increases risk of cellular mediated allograft rejection in heart transplanted recipients., PMID:39642779
Curcumin inhibits the proliferation and migration of osteosarcoma by regulating the expression of super-enhancer-associated genes., PMID:39019783
Coexistence of systemic sclerosis and cryopyrin-associated periodic syndrome., PMID:38940218
LIM Zinc Finger Domain Containing 1 Risk Genotype of Recipient Is Associated with Renal Tubular Inflammation in Kidney Transplantation., PMID:38927709
Circulating Autoantibody Profiling Identifies LIMS1 as a Potential Target for Pathogenic Autoimmunity in pathologic Myopia., PMID:38729610
HIF-1α and adaptor protein LIM and senescent cell antigen-like domains protein 1 axis promotes tubulointerstitial fibrosis by interacting with vimentin in angiotensin II-induced hypertension., PMID:38698737
The RNA-binding protein RBMS3 inhibits the progression of colon cancer by regulating the stability of LIMS1 mRNA., PMID:38618967
Regulatory T cells in kidney transplant recipients with LIMS1 rs893403 risk genotype., PMID:38545889
Therapeutic role of miR-26a on cardiorenal injury in a mice model of angiotensin-II induced chronic kidney disease through inhibition of LIMS1/ILK pathway., PMID:38445356
The bone-liver interaction modulates immune and hematopoietic function through Pinch-Cxcl12-Mbl2 pathway., PMID:38062244
Multiscale genetic architecture of donor-recipient differences reveals intronic LIMS1 mismatches associated with kidney transplant survival., PMID:37676733
Landscape of semi-extractable RNAs across five human cell lines., PMID:37463833
HSF4/COIL complex-dependent R-loop mediates ultraviolet-induced inflammatory skin injury., PMID:37461263
Mismatches in Gene Deletions and Kidney-related Proteins as Candidates for Histocompatibility Factors in Kidney Transplantation., PMID:36531875
Requirement for PINCH in skeletal myoblast differentiation., PMID:36385586
Analysis of Ser/Thr Kinase HASPIN-Interacting Proteins in the Spermatids., PMID:36012324
Identification of Key Genes as Early Warning Signals of Acute Myocardial Infarction Based on Weighted Gene Correlation Network Analysis and Dynamic Network Biomarker Algorithm., PMID:35795669
Pinch Loss Ameliorates Obesity, Glucose Intolerance, and Fatty Liver by Modulating Adipocyte Apoptosis in Mice., PMID:34380695
PINCH-1 promotes Δ1-pyrroline-5-carboxylate synthase expression and contributes to proline metabolic reprogramming in lung adenocarcinoma., PMID:34283311
Single-cell transcriptomic analysis reveals disparate effector differentiation pathways in human Treg compartment., PMID:34162888
LIMS1 risk genotype and T cell-mediated rejection in kidney transplant recipients., PMID:33909908
Molecular basis for Ras suppressor-1 binding to PINCH-1 in focal adhesion assembly., PMID:33891945
Complex structures of Rsu1 and PINCH1 reveal a regulatory mechanism of the ILK/PINCH/Parvin complex for F-actin dynamics., PMID:33587032
Disruption of the integrin-linked kinase (ILK) pseudokinase domain affects kidney development in mice., PMID:33539921
A mechanoresponsive PINCH-1-Notch2 interaction regulates smooth muscle differentiation of human placental mesenchymal stem cells., PMID:33529444
Effects of purposeful soccer heading on circulating small extracellular vesicle concentration and cargo., PMID:33189894
PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth., PMID:33004813
MicroRNA-Dependent Targeting of RSU1 and the IPP Adhesion Complex Regulates the PTEN/PI3K/AKT Signaling Pathway in Breast Cancer Cell Lines., PMID:32751711
Inflammation-induced PINCH expression leads to actin depolymerization and mitochondrial mislocalization in neurons., PMID:32746944
Silencing of Growth Differentiation Factor-15 Promotes Breast Cancer Cell Invasion by Down-regulating Focal Adhesion Genes., PMID:32132034
Genetic background and transplantation outcomes: insights from genome-wide association studies., PMID:31815792
PINCH-1 interacts with myoferlin to promote breast cancer progression and metastasis., PMID:31801973
Focal adhesion proteins Pinch1 and Pinch2 regulate bone homeostasis in mice., PMID:31723057
NME2 Is a Master Suppressor of Apoptosis in Gastric Cancer Cells via Transcriptional Regulation of miR-100 and Other Survival Factors., PMID:31694930
A PINCH-1-Smurf1 signaling axis mediates mechano-regulation of BMPR2 and stem cell differentiation., PMID:31578224
Depletion of Ras Suppressor-1 (RSU-1) promotes cell invasion of breast cancer cells through a compensatory upregulation of a truncated isoform., PMID:31296919
Genomic Mismatch at LIMS1 Locus and Kidney Allograft Rejection., PMID:31091373
Evidence for skeletal muscle fiber type-specific expressions of mechanosensors., PMID:30701284
LIMS1 Promotes Pancreatic Cancer Cell Survival under Oxygen-Glucose Deprivation Conditions by Enhancing HIF1A Protein Translation., PMID:30679163
Inhibition of Breast Cancer Cell Invasion by Ras Suppressor-1 (RSU-1) Silencing Is Reversed by Growth Differentiation Factor-15 (GDF-15)., PMID:30621163
Non-catalytic signaling by pseudokinase ILK for regulating cell adhesion., PMID:30367047
Bioinformatic screening for key miRNAs and genes associated with myocardial infarction., PMID:29928570
Genome-wide association study in Japanese females identifies fifteen novel skin-related trait associations., PMID:29895819
High PINCH1 Expression in Human Laryngeal Carcinoma Associates with Poor Prognosis., PMID:29755929
Experimental and integrative analyses identify an ETS1 network downstream of BCR-ABL in chronic myeloid leukemia (CML)., PMID:29733872
Chromatin Immunoprecipitation and DNA Sequencing Identified a LIMS1/ILK Pathway Regulated by LMO1 in Neuroblastoma., PMID:29695398
For research use only. Not for human or drug use.
