Catalog No.
YHE48801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Val99-Leu343
Predicted molecular weight
30.56 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P46734
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
SAPK kinase 2, PRKMK3, Dual specificity mitogen-activated protein kinase kinase 3, MAPKK 3, SAPKK-2, MAP2K3, SKK2, MAP kinase kinase 3, SAPKK2, MEK3, Stress-activated protein kinase kinase 2, MKK3, MAPK/ERK kinase 3, MEK 3
Employing steered MD simulations for effective virtual screening: Active pharmacophore search by dynamic corrections to target MKK3-MYC interactions., PMID:40157686
Long-term aerobic exercise enhances liver health: miRNA regulation and oxidative stress alleviation., PMID:40138760
Proteomic insights into the molecular mechanism of anlotinib inhibition in TP53-mutated non-small cell lung cancer., PMID:40113013
Identifcation of the FGF family as therapeutic targets and prognostic biomarkers in the microenvironment of head and neck squamous cell carcinoma., PMID:40086631
Comprehensive characterization of pathogenic missense CTRP6 variants and their association with cancer., PMID:39979869
Phospholipase C β4 promotes RANKL-dependent osteoclastogenesis by interacting with MKK3 and p38 MAPK., PMID:39894822
Circulating free heme induces cytokine storm and pulmonary hypertension through the MKK3/p38 axis., PMID:39197168
Repurposed AT9283 triggers anti-tumoral effects by targeting MKK3 oncogenic functions in Colorectal Cancer., PMID:39164711
MKK3 depletion attenuates intestinal injury after traumatic hemorrhagic shock by restoring mitochondrial function., PMID:38904879
Defining the heterogeneous molecular landscape of lung cancer cell responses to epigenetic inhibition., PMID:38853901
Modeling Molecular Mechanisms of Pirfenidone Interaction with Kinases., PMID:38585747
Pharmacogenomics of intravenous immunoglobulin response in Kawasaki disease., PMID:38259468
Development of a TLR-Based Model That Can Predict Prognosis, Tumor Microenvironment, and Drug Response for Esophageal Squamous Cell Carcinoma., PMID:38206423
Transcriptome Profiling of Vero E6 Cells during Original Parental or Cell-Attenuated Porcine Epidemic Diarrhea Virus Infection., PMID:37515115
Peripheral blood mononuclear cell- transcriptome signatures of atopic dermatitis and prediction for the efficacy of dupilumab., PMID:37349237
Leydig cell development in pubertal male rats is blocked by perfluorotetradecanoic acid through decreasing AMPK-mTOR-autophagy pathway., PMID:37269911
Identification of MAP Kinase Kinase 3 as a protein target of myricetin in non-small cell lung cancer cells., PMID:36870282
[Mechanism of miRNA-3679 Inhibiting Downstream ZADH2-Target Genes to Promote Hepatocellular Carcinoma Cell Proliferation]., PMID:36224673
Clinical and genetic analyses of patients with lateralized overgrowth., PMID:36175890
MKK6 deficiency promotes cardiac dysfunction through MKK3-p38γ/δ-mTOR hyperactivation., PMID:35971771
P-Rex1 Signaling Hub in Lower Grade Glioma Patients, Found by In Silico Data Mining, Correlates With Reduced Survival and Augmented Immune Tumor Microenvironment., PMID:35875157
Mass Spectrometry-Based Quantitative Proteomics Analysis for Better Understanding of Telomeric Zinc Finger-Associated Protein-Induced Pathogenesis in Cardiomyocytes., PMID:35650157
Gamma synuclein promotes cancer metastasis through the MKK3/6-p38MAPK cascade., PMID:35637967
FIP-fve Stimulates Cell Proliferation and Enhances IL-2 Release by Activating MAP2K3/p38α (MAPK14) Signaling Pathway in Jurkat E6-1 Cells., PMID:35614983
Fenbendazole and its synthetic analog interfere with HeLa cells' proliferation and energy metabolism via inducing oxidative stress and modulating MEK3/6-p38-MAPK pathway., PMID:35569513
Discovery of First-in-Class TAK1-MKK3 Protein-Protein Interaction (PPI) Inhibitor (R)-STU104 for the Treatment of Ulcerative Colitis through Modulating TNF-α Production., PMID:35442672
Decoding the role of inflammation-related microRNAs in cancer cachexia: a study using HPV16-transgenic mice and in silico approaches., PMID:35298788
Receptor for advanced glycation end products aggravates cognitive deficits in type 2 diabetes through binding of C-terminal AAs 2-5 to mitogen-activated protein kinase kinase 3 (MKK3) and facilitation of MEKK3-MKK3-p38 module assembly., PMID:35080104
Identification of Differentially Expressed Genes in Different Glioblastoma Regions and Their Association with Cancer Stem Cell Development and Temozolomide Response., PMID:34834399
Quadruple and Truncated MEK3 Mutants Identified from Acute Lymphoblastic Leukemia Promote Degradation and Enhance Proliferation., PMID:34830095
Key Common Genes in Obstructive Sleep Apnea and Lung Cancer are Associated with Prognosis of Lung Cancer Patients., PMID:34526807
Knockdown of Mitogen-Activated Protein Kinase Kinase 3 Negatively Regulates Hepatitis A Virus Replication., PMID:34299039
Cardiomyocyte-produced miR-339-5p mediates pathology in Duchenne muscular dystrophy cardiomyopathy., PMID:34270708
Sevoflurane pretreatment regulates abnormal expression of MicroRNAs associated with spinal cord ischemia/reperfusion injury in rats., PMID:34268365
YTHDF2 mediates LPS-induced osteoclastogenesis and inflammatory response via the NF-κB and MAPK signaling pathways., PMID:34089814
Identification of the biological function of miR-9 in spinal cord ischemia-reperfusion injury in rats., PMID:34035993
Cutaneous innate immune tolerance is mediated by epigenetic control of MAP2K3 by HDAC8/9., PMID:34021025
MTA2 silencing attenuates the metastatic potential of cervical cancer cells by inhibiting AP1-mediated MMP12 expression via the ASK1/MEK3/p38/YB1 axis., PMID:33958583
MAP3K4 kinase activity dependent control of mouse gonadal sex determination†., PMID:33912929
Whole-Exome Sequencing Reveals Novel Variations in Patients with Familial Von Hippel-Lindau Syndrome., PMID:33774214
The miR-19b-3p-MAP2K3-STAT3 feedback loop regulates cell proliferation and invasion in esophageal squamous cell carcinoma., PMID:33660414
Panax Notoginseng Saponins Inhibits Ventricular Remodeling after Myocardial Infarction in Rats Through Regulating ATF3/MAP2K3/p38 MAPK and NF κ B Pathway., PMID:33259022
Pharmacological validation of targets regulating CD14 during macrophage differentiation., PMID:33038762
Epigenetic stratification of head and neck cancer survivors reveals differences in lycopene levels, alcohol consumption, and methylation of immune regulatory genes., PMID:32917280
Sulforaphene inhibits esophageal cancer progression via suppressing SCD and CDH3 expression, and activating the GADD45B-MAP2K3-p38-p53 feedback loop., PMID:32873775
MiR-92b-3p ameliorates inflammation and autophagy by targeting TRAF3 and suppressing MKK3-p38 pathway in caerulein-induced AR42J cells., PMID:32822908
Genome-wide RNA interference screening reveals a COPI-MAP2K3 pathway required for YAP regulation., PMID:32747557
Therapeutic potential of targeting MKK3-p38 axis with Capsaicin for Nasopharyngeal Carcinoma., PMID:32685028
Linc02381 Exacerbates Rheumatoid Arthritis Through Adsorbing miR-590-5p and Activating the Mitogen-Activated Protein Kinase Signaling Pathway in Rheumatoid arthritis-fibroblast-like synoviocytes., PMID:32608996
Research on the structural characteristics of a novel Chinese Iron Yam polysaccharide and its gastroprotection mechanism against ethanol-induced gastric mucosal lesion in a BALB/c mouse model., PMID:32558848
For research use only. Not for human or drug use.
