Catalog No.
YHE48201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Thr198
Predicted molecular weight
24.38 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P46527
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Cyclin-dependent kinase inhibitor 1B, KIP1, CDKN1B, p27Kip1, Cyclin-dependent kinase inhibitor p27
Correction: Absence of cyclin-dependent kinase inhibitor p27 or p18 increases efficiency of iPSC generation without induction of iPSC genomic instability., PMID:40419533
Curcumin induces apoptosis via downregulation of SKP2 and induction of GADD45A/CDKN1A expression through generation of ROS in cutaneous T-cell lymphoma cells., PMID:40409732
Inhibition of Dormant Lung Cancer Cell Reactivation by Punica Granatum Peel and Dioscorea Nipponica: Involving MYC, SKP2 and p27., PMID:40391177
Case Report: Late diagnosis of McCune-Albright with severe kyphoscoliosis, acromegaly and tertiary hyperparathyroidism., PMID:40357201
Plasmacytoid urothelial carcinoma of the urinary bladder: A single institution experience with focus on next-generation sequencing (NGS) and PD-L1 immunohistochemistry., PMID:40349989
Cell cycle duration determines oncogenic transformation capacity., PMID:40307557
In Vivo Antitumor Activity of Allicin in a Pediatric Neuroblastoma Patient-derived Xenograft (PDX) Mouse Model., PMID:40295032
KRIBB11 Exerts Anticancer Effects on A172 Glioblastoma Cells via the Cdh1/SKP2/p27 and HSF1/p53/p21 Pathways., PMID:40280718
Astragalus mongholicus and Hedyotis diffusa willd inhibit cell proliferation by attenuating the miR-582-3p-p27 signaling pathway in LUAD., PMID:40251292
YTHDF1/RNF7/p27 axis promotes prostate cancer progression., PMID:40251202
The Hippo pathway and p27Kip1 cooperate to suppress mitotic regeneration in the organ of Corti and the retina., PMID:40178894
Simultaneous cyclin D1 overexpression and p27kip1 knockdown enable robust Müller glia cell cycle reactivation in uninjured mouse retina., PMID:40178080
Macrophage Subpopulation Promotes Skeletal Muscle Regeneration Through HGF/MET Signaling-Mediated Skeletal Muscle Stem Cell Proliferation., PMID:40132988
Flavokawain a induces cell cycle arrest through CDT1-dependent p27 regulation and synergizes with venetoclax in acute myeloid leukemia., PMID:40113097
CUL1-neddylation contributes to K29-linked ubiquitination on p27 for autophagic degradation in sorafenib-resistant liver cancer., PMID:40111576
Prioritization of prognostic biomarkers regulated by calorie restriction in colon cancer through integrated biosignature analysis., PMID:40111533
ARv7 promotes the escape of prostate cancer cells from androgen deprivation therapy-induced senescence by mediating the SKP2/p27 axis., PMID:40022149
A novel likely pathogenic germline variant in CDKN1B in a patient with MEN4 and medullary thyroid cancer., PMID:40009226
EGFR tyrosine kinase inhibitor ZZC4 overcomes acquired resistance to gefitinib., PMID:39999922
Distinct outcomes from targeted perturbations of the multi-subunit SCFSkp2 E3 ubiquitin ligase in blocking Trp53/Rb1-null prostate tumorigenesis., PMID:39987265
Anaplastic meningioma in a 6-year-old with somatic YAP1::MAML2 fusion and multiple endocrine neoplasia type 4 (MEN4) syndrome., PMID:39985924
Increased turnover of nonmalignant T lymphocytes in patients with chronic lymphocytic leukemia may affect clinical progression., PMID:39950487
RNF6 promotes cell proliferation of glioblastoma by targeting ubiquitin-mediated degradation of p27., PMID:39938447
p27Kip1 and Tumors: Characterization of CDKN1B Variants Identified in MEN4 and Breast Cancer., PMID:39936980
State of thermal tolerance in an endangered himalayan fish Tor putitora revealed by expression modulation in environmental stress related genes., PMID:39934267
A novel missense mutation Smad4 V354L enhances the efficacy of docetaxel in non-small cell lung cancer., PMID:39923405
KLF9 aggravates the cardiomyocyte hypertrophy in hypertrophic obstructive cardiomyopathy through the lncRNA UCA1/p27 axis., PMID:39909852
Identification and Validation of Pivotal Genes in Osteoarthritis Combined with WGCNA Analysis., PMID:39906135
Cyclin E Expression and p16 Loss Are Strong Prognostic Biomarkers in Primary Invasive Cutaneous Melanoma., PMID:39890162
Micropeptide hSPAR regulates glutamine levels and suppresses mammary tumor growth via a TRIM21-P27KIP1-mTOR axis., PMID:39875724
Promotion of beta cell proliferation through DYRK kinase inhibition using the marine natural product breitfussin C., PMID:39774736
3,6-Anhydro-L-galactose suppresses mouse lymphocyte proliferation by attenuating JAK-STAT growth factor signal transduction and G1-S cell cycle progression., PMID:39764992
Comprehensive characterization of MCL-1 in patients with colorectal cancer: Expression, molecular profiles, and outcomes., PMID:39740007
Red ginseng prevents niraparib-induced myelosuppression in C57BL/6 mice via inhibiting p53-mediated upregulation of p21 and p27., PMID:39739292
Cyclosporine A causes gingival overgrowth via reduced G1 cell cycle arrest in gingival fibroblasts., PMID:39705288
Functional circuits of LYL1 controlled by supraphysiological androgen in prostate cancer cells to regulate cell senescence., PMID:39668349
Cyclin-dependent kinase inhibitor p18 regulates lineage transitions of excitatory neurons, astrocytes, and interneurons in the mouse cortex., PMID:39668249
Non-Immune-Mediated, p27-Associated, Growth Inhibition of Glioblastoma by Class-II-Transactivator (CIITA)., PMID:39594630
A meta-analysis of the prognostic significance of CDKN deletions in acute lymphoblastic leukaemia., PMID:39552434
The expression of keratin 17 and p27 predicts clinical outcomes in colorectal cancer., PMID:39529547
Association of Genetic Variants at the CDKN1B and CCND2 Loci Encoding p27Kip1 and Cyclin D2 Cell Cycle Regulators with Susceptibility and Clinical Course of Chronic Lymphocytic Leukemia., PMID:39519258
Molecular Pathophysiology of Parathyroid Tumorigenesis-The Lesson from a Rare Disease: The "MEN1 Model"., PMID:39519139
Inhibition of Chk1 with Prexasertib Enhances the Anticancer Activity of Ciclopirox in Non-Small Cell Lung Cancer Cells., PMID:39513859
NEK2 Promotes ESCC Malignant Progression by Inhibiting Cellular Senescence via the FOXM1/c-Myc/p27 Signaling Pathway., PMID:39503194
Correlation of Magnetic Resonance Imaging and Computed Tomography with Biological Factor Expression and Lymph Node Metastasis in Aggressive Prostate Cancer., PMID:39462504
p57Kip2 Phosphorylation Modulates Its Localization, Stability, and Interactions., PMID:39456957
Suppressive cancer nonstop extension mutations increase C-terminal hydrophobicity and disrupt evolutionarily conserved amino acid patterns., PMID:39448564
Circular RNA TAF4B targeting MFN2 accelerates cell growth in bladder cancer through p27 depression and AKT activation., PMID:39430741
miR-326 overexpression inhibits colorectal cancer cell growth and proteasome activity by targeting PNO1: unveiling a novel therapeutic intervention strategy., PMID:39414903
Heterogeneous Transcriptional Landscapes in Human Sporadic Parathyroid Gland Tumors., PMID:39409111
For research use only. Not for human or drug use.
