Catalog No.
YHE35501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Tyr300
Predicted molecular weight
59.58 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P42356
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PI4K-alpha, PtdIns-4-kinase alpha, Phosphatidylinositol 4-Kinase III alpha, PIK4, Phosphatidylinositol 4-kinase alpha, PIK4CA, PI4KA, PI4-kinase alpha
A phosphatidylinositol 4-kinase alpha (PI4KA) gene reduces plant height of common wheat., PMID:40348068
A Potential Role of EFR3A in Human Disease States., PMID:40305161
The First Known Case Report of a Novel Homozygous Nonsense Variant in the OSBPL9 Gene Associated With Fetal Cerebral Ventriculomegaly, Cerebellar Hypoplasia, and Arthrogryposis Multiplex., PMID:40182349
EFR3A, an Intriguing Gene, and Protein with a Scaffolding Function., PMID:40136694
TTC7B triggers the PI4KA-AKT1-RXRA-FTO axis and inhibits colon cancer cell proliferation by increasing RNA methylation., PMID:39897037
Identifying novel heterozygous PI4KA variants in fetal abnormalities., PMID:39885450
Molecular basis for plasma membrane recruitment of PI4KA by EFR3., PMID:39705356
Visualizing the dual interaction of calcineurin with PI4KA and FAM126A., PMID:39515303
Biallelic PI4KA Mutations Disrupt B-Cell Metabolism and Cause B-Cell Lymphopenia and Hypogammaglobulinemia., PMID:39312004
Structure of calcineurin bound to PI4KA reveals dual interface in both PI4KA and FAM126A., PMID:39216471
Molecular basis for plasma membrane recruitment of PI4KA by EFR3., PMID:38746453
Identification of genetic modifiers enhancing B7-H3-targeting CAR T cell therapy against glioblastoma through large-scale CRISPRi screening., PMID:38561797
A Novel Interaction between Chemokine and Phosphoinositide Signaling in Metastatic Prostate Cancer., PMID:38239314
Effect of hormone-induced plasma membrane phosphatidylinositol 4,5-bisphosphate depletion on receptor endocytosis suggests the importance of local regulation in phosphoinositide signaling., PMID:38168911
Genetic Heterogeneity Underlying Phenotypes with Early-Onset Cerebellar Atrophy., PMID:38003592
Adaptor proteins mediate CXCR4 and PI4KA crosstalk in prostate cancer cells and the significance of PI4KA in bone tumor growth., PMID:37996444
Structural basis for the conserved roles of PI4KA and its regulatory partners and their misregulation in disease., PMID:37979461
PI4KA and PIKfyve: Essential phosphoinositide signaling enzymes involved in myriad human diseases., PMID:37453227
Rare coding variants as risk modifiers of the 22q11.2 deletion implicate postnatal cortical development in syndromic schizophrenia., PMID:36869225
Adaptor proteins mediate CXCR4 and PI4KA crosstalk in prostate cancer cells and the significance of PI4KA in bone tumor growth., PMID:36865146
PIP5K1C phosphoinositide kinase deficiency distinguishes PIKFYVE-dependent cancer cells from non-malignant cells., PMID:36803256
Curcumol inhibits EMCV replication by activating CH25H and inhibiting the formation of ROs., PMID:36572890
Comparison of milk fat globule membrane protein profile among bovine, goat and camel milk based on label free proteomic techniques., PMID:36461403
Effect of selenium nanoparticles on alternative splicing in heat-stressed rainbow trout primary hepatocytes., PMID:36455514
A synonymous mutation in PI4KA impacts the transcription and translation process of gene expression., PMID:36341355
Targeting PI4KA sensitizes refractory leukemia to chemotherapy by modulating the ERK/AMPK/OXPHOS axis., PMID:36276647
Human CPTP promotes growth and metastasis via sphingolipid metabolite ceramide and PI4KA/AKT signaling in pancreatic cancer cells., PMID:35982909
Molecular mechanisms of PI4K regulation and their involvement in viral replication., PMID:35579216
Calcium-Prolactin Secretion Coupling in Rat Pituitary Lactotrophs Is Controlled by PI4-Kinase Alpha., PMID:35058881
Dishevelled coordinates phosphoinositide kinases PI4KIIIα and PIP5KIγ for efficient PtdInsP2 synthesis., PMID:34982154
Components of the phosphatidylserine endoplasmic reticulum to plasma membrane transport mechanism as targets for KRAS inhibition in pancreatic cancer., PMID:34903667
Palmitoylation targets the calcineurin phosphatase to the phosphatidylinositol 4-kinase complex at the plasma membrane., PMID:34663815
Oncogenic KRAS is dependent upon an EFR3A-PI4KA signaling axis for potent tumorigenic activity., PMID:34504076
Biallelic PI4KA variants cause a novel neurodevelopmental syndrome with hypomyelinating leukodystrophy., PMID:34415322
Sevoflurane Suppresses Colon Cancer Cell Malignancy by Regulating circ-PI4KA., PMID:34045869
Phosphatidylinositol 4,5-bisphosphate is regenerated by speeding of the PI 4-kinase pathway during long PLC activation., PMID:33186442
Drugging the Phosphoinositide 3-Kinase (PI3K) and Phosphatidylinositol 4-Kinase (PI4K) Family of Enzymes for Treatment of Cancer, Immune Disorders, and Viral/Parasitic Infections., PMID:32894512
Synaptic and Gene Regulatory Mechanisms in Schizophrenia, Autism, and 22q11.2 Copy Number Variant-Mediated Risk for Neuropsychiatric Disorders., PMID:31500805
Leukocyte Cytoskeleton Polarization Is Initiated by Plasma Membrane Curvature from Cell Attachment., PMID:30930167
Characterization of a Threonine-Rich Cluster in Hepatitis C Virus Nonstructural Protein 5A and Its Contribution to Hyperphosphorylation., PMID:30258001
Probing the Architecture, Dynamics, and Inhibition of the PI4KIIIα/TTC7/FAM126 Complex., PMID:30031006
Regulation of PI4P levels by PI4KIIIα during G-protein-coupled PLC signaling in Drosophila photoreceptors., PMID:29980590
Accurate diagnosis of spinal muscular atrophy and 22q11.2 deletion syndrome using limited deoxynucleotide triphosphates and high-resolution melting., PMID:29925309
Schwann-Cell-Specific Deletion of Phosphatidylinositol 4-Kinase Alpha Causes Aberrant Myelination., PMID:29874576
Extruded linseed alone or in combination with fish oil modifies mammary gene expression profiles in lactating goats., PMID:29122055
Mutations in Encephalomyocarditis Virus 3A Protein Uncouple the Dependency of Genome Replication on Host Factors Phosphatidylinositol 4-Kinase IIIα and Oxysterol-Binding Protein., PMID:27303747
Lenz-Majewski mutations in PTDSS1 affect phosphatidylinositol 4-phosphate metabolism at ER-PM and ER-Golgi junctions., PMID:27044099
Hepatitis C virus NS5A protein cooperates with phosphatidylinositol 4-kinase IIIα to induce mitochondrial fragmentation., PMID:27010100
Derivation of original RESP atomic partial charges for MD simulations of the LDAO surfactant with AMBER: applications to a model of micelle and a fragment of the lipid kinase PI4KA., PMID:26998712
Modulation of the Host Lipid Landscape to Promote RNA Virus Replication: The Picornavirus Encephalomyocarditis Virus Converges on the Pathway Used by Hepatitis C Virus., PMID:26406250
For research use only. Not for human or drug use.
