Catalog No.
YHD90401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala146-Leu484
Predicted molecular weight
40.78 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P30566
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Adenylosuccinase, ADSL, AMPS, ASase, Adenylosuccinate lyase, ASL
Note
For research use only.
Modulation of de novo purine biosynthesis leads to activation of AMPK and results in improved glucose handling and insulin sensitivity., PMID:24855629
Fumaric acid production by Torulopsis glabrata: engineering the urea cycle and the purine nucleotide cycle., PMID:25060134
Adenylosuccinate lyase deficiency., PMID:25112391
The nonessentiality of essential genes in yeast provides therapeutic insights into a human disease., PMID:27440870
Analysis of extended haplotype in Korean cattle (Hanwoo) population., PMID:27470211
Associations between inflammation-related biomarkers and depressive symptoms in individuals with recently diagnosed type 1 and type 2 diabetes., PMID:28041985
Structural and kinetic analysis of Schistosoma mansoni Adenylosuccinate Lyase (SmADSL)., PMID:28347672
Adenylosuccinate lyase enhances aggressiveness of endometrial cancer by increasing killer cell lectin-like receptor C3 expression by fumarate., PMID:29467457
Proteomics of Stored Red Blood Cell Membrane and Storage-Induced Microvesicles Reveals the Association of Flotillin-2 With Band 3 Complexes., PMID:29780325
Association of ADSL gene polymorphisms with meat quality and carcass traits in domestic pigeons (Columba livia)., PMID:29963908
Molecular comparison of Neanderthal and Modern Human adenylosuccinate lyase., PMID:30573755
Purine Homeostasis Is Necessary for Developmental Timing, Germline Maintenance and Muscle Integrity in Caenorhabditis elegans., PMID:30700528
Comparative transcriptome analysis of skeletal muscle in ADSSL1 myopathy., PMID:30853170
An integrative approach using systems biology, mutational analysis with molecular dynamics simulation to challenge the functionality of a target protein., PMID:30891955
Effects of the MC4R, CAPN1, and ADSL genes on body weight and purine content in slow-growing chickens., PMID:31111951
Prolyl hydroxylase substrate adenylosuccinate lyase is an oncogenic driver in triple negative breast cancer., PMID:31729379
Adenylosuccinate lyase hydroxylation contributes to triple negative breast cancer via the activation of cMYC., PMID:32158921
In silico Metabolic Pathway Analysis Identifying Target Against Leishmaniasis - A Kinetic Modeling Approach., PMID:32211028
The CRISPR-Cas9 crATIC HeLa transcriptome: Characterization of a novel cellular model of ATIC deficiency and ZMP accumulation., PMID:32939338
Investigating Immunization With Nucleotide Enzymes of Schistosoma mansoni: Nucleoside Diphosphate Kinase and Adenylosuccinate Lyase as New Antigenic Targets Against Schistosomiasis., PMID:33072110
Crtc modulates fasting programs associated with 1-C metabolism and inhibition of insulin signaling., PMID:33723074
Adenylosuccinate lyase is oncogenic in colorectal cancer by causing mitochondrial dysfunction and independent activation of NRF2 and mTOR-MYC-axis., PMID:33754045
Proteome and transcriptome analysis revealed florfenicol via affected drug metabolism and lipid metabolism induce liver injury of broilers., PMID:34293615
Carcinogenic effect of adenylosuccinate lyase (ADSL) in prostate cancer development and progression through the cell cycle pathway., PMID:34488772
[Identification of LAMTOR1-regulated metabolites using ultra-performance liquid chromatography coupled with time-of-flight mass spectrometry in malignant transformation of liver inflammation]., PMID:34505434
Pathway-specific effects of ADSL deficiency on neurodevelopment., PMID:35133277
Combined Targeted and Untargeted Profiling of HeLa Cells Deficient in Purine De Novo Synthesis., PMID:35323684
Investigation of the Mechanism of Periploca forrestii against Rheumatoid Arthritis with Network Pharmacology-Based Analysis., PMID:35836835
MicroRNA-21 guide and passenger strand regulation of adenylosuccinate lyase-mediated purine metabolism promotes transition to an EGFR-TKI-tolerant persister state., PMID:35840668
Identification of a novel recurrent EEF2 gene amplification in familial prostate tumors., PMID:36520140
Effect of Mulberry Leaf TMR on Growth Performance, Meat Quality and Expression of Meat Quality Master Genes (ADSL, H-FABP) in Crossbred Black Goats., PMID:36553774
Dietary intake of fructose increases purine de novo synthesis: A crucial mechanism for hyperuricemia., PMID:36601078
High fructose-induced skeletal muscle insulin resistance could be alleviated by berberine via AMPD1 and ADSL., PMID:36931587
Engineered soluble, trimerized 4-1BBL variants as potent immunomodulatory agents., PMID:37310433
Profiling A-to-I RNA editing during mouse somatic reprogramming at the single-cell level., PMID:37519753
Adenylosuccinate lyase deficiency affects neurobehavior via perturbations to tyramine signaling in Caenorhabditis elegans., PMID:37773959
Electroclinical features and phenotypic differences in adenylosuccinate lyase deficiency: Long-term follow-up of seven patients from four families and appraisal of the literature., PMID:37842880
A new physiological medium uncovers biochemical and cellular alterations in Lesch-Nyhan disease fibroblasts., PMID:38172668
Reactivating PTEN to impair glioma stem cells by inhibiting cytosolic iron-sulfur assembly., PMID:38507470
Arg40 is critical for stability and activity of Adenylosuccinate lyase; a purine salvage enzyme from Leishmania donovani., PMID:38750922
Weak purifying selection in allelic diversity of the ADSL gene in indigenous and local chicken breeds and red junglefowl in Thailand., PMID:38768877
Nrf2-mediated adenylosuccinate lyase promotes resistance to gemcitabine in pancreatic ductal adenocarcinoma cells through ferroptosis escape., PMID:39164986
The quality of Tibetan sheep meat from pastures was synergistically regulated by the rumen microbiota and related genes at different phenological stages., PMID:39840335
Integrative Bioinformatics and Experimental Validation Reveal the Mechanistic Action of Patchouli Alcohol in Prostate Cancer Treatment., PMID:39844397
ADSL promotes autophagy and tumor growth through fumarate-mediated Beclin1 dimethylation., PMID:39881212
Mechanism of Formononetin in Improving Energy Metabolism and Alleviating Neuronal Injury in CIRI Based on Nontargeted Metabolomics Research., PMID:39993962
Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single-cell RNA sequencing analysis., PMID:40017120
ADSL-generated fumarate binds and inhibits STING to promote tumour immune evasion., PMID:40033100
ADSL-produced fumarate increases BECN1 dimethylation to promote autophagy and liver tumor growth., PMID:40103200
Phosphoribosylformylglycinamidine Synthase (PFAS) Deficiency: Clinical, Genetic and Metabolic Characterisation of a Novel Defect in Purine de Novo Synthesis., PMID:40421664
For research use only. Not for human or drug use.
