Catalog No.
YHD90401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala146-Leu484
Predicted molecular weight
40.78 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P30566
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Adenylosuccinase, ADSL, AMPS, ASase, Adenylosuccinate lyase, ASL
Phosphoribosylformylglycinamidine Synthase (PFAS) Deficiency: Clinical, Genetic and Metabolic Characterisation of a Novel Defect in Purine de Novo Synthesis., PMID:40421664
ADSL-produced fumarate increases BECN1 dimethylation to promote autophagy and liver tumor growth., PMID:40103200
ADSL-generated fumarate binds and inhibits STING to promote tumour immune evasion., PMID:40033100
Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single-cell RNA sequencing analysis., PMID:40017120
Mechanism of Formononetin in Improving Energy Metabolism and Alleviating Neuronal Injury in CIRI Based on Nontargeted Metabolomics Research., PMID:39993962
ADSL promotes autophagy and tumor growth through fumarate-mediated Beclin1 dimethylation., PMID:39881212
Integrative Bioinformatics and Experimental Validation Reveal the Mechanistic Action of Patchouli Alcohol in Prostate Cancer Treatment., PMID:39844397
The quality of Tibetan sheep meat from pastures was synergistically regulated by the rumen microbiota and related genes at different phenological stages., PMID:39840335
Nrf2-mediated adenylosuccinate lyase promotes resistance to gemcitabine in pancreatic ductal adenocarcinoma cells through ferroptosis escape., PMID:39164986
Weak purifying selection in allelic diversity of the ADSL gene in indigenous and local chicken breeds and red junglefowl in Thailand., PMID:38768877
Arg40 is critical for stability and activity of Adenylosuccinate lyase; a purine salvage enzyme from Leishmania donovani., PMID:38750922
Reactivating PTEN to impair glioma stem cells by inhibiting cytosolic iron-sulfur assembly., PMID:38507470
A new physiological medium uncovers biochemical and cellular alterations in Lesch-Nyhan disease fibroblasts., PMID:38172668
Electroclinical features and phenotypic differences in adenylosuccinate lyase deficiency: Long-term follow-up of seven patients from four families and appraisal of the literature., PMID:37842880
Adenylosuccinate lyase deficiency affects neurobehavior via perturbations to tyramine signaling in Caenorhabditis elegans., PMID:37773959
Profiling A-to-I RNA editing during mouse somatic reprogramming at the single-cell level., PMID:37519753
Engineered soluble, trimerized 4-1BBL variants as potent immunomodulatory agents., PMID:37310433
High fructose-induced skeletal muscle insulin resistance could be alleviated by berberine via AMPD1 and ADSL., PMID:36931587
Dietary intake of fructose increases purine de novo synthesis: A crucial mechanism for hyperuricemia., PMID:36601078
Effect of Mulberry Leaf TMR on Growth Performance, Meat Quality and Expression of Meat Quality Master Genes (ADSL, H-FABP) in Crossbred Black Goats., PMID:36553774
Identification of a novel recurrent EEF2 gene amplification in familial prostate tumors., PMID:36520140
MicroRNA-21 guide and passenger strand regulation of adenylosuccinate lyase-mediated purine metabolism promotes transition to an EGFR-TKI-tolerant persister state., PMID:35840668
Investigation of the Mechanism of Periploca forrestii against Rheumatoid Arthritis with Network Pharmacology-Based Analysis., PMID:35836835
Combined Targeted and Untargeted Profiling of HeLa Cells Deficient in Purine De Novo Synthesis., PMID:35323684
Pathway-specific effects of ADSL deficiency on neurodevelopment., PMID:35133277
[Identification of LAMTOR1-regulated metabolites using ultra-performance liquid chromatography coupled with time-of-flight mass spectrometry in malignant transformation of liver inflammation]., PMID:34505434
Carcinogenic effect of adenylosuccinate lyase (ADSL) in prostate cancer development and progression through the cell cycle pathway., PMID:34488772
Proteome and transcriptome analysis revealed florfenicol via affected drug metabolism and lipid metabolism induce liver injury of broilers., PMID:34293615
Adenylosuccinate lyase is oncogenic in colorectal cancer by causing mitochondrial dysfunction and independent activation of NRF2 and mTOR-MYC-axis., PMID:33754045
Crtc modulates fasting programs associated with 1-C metabolism and inhibition of insulin signaling., PMID:33723074
Investigating Immunization With Nucleotide Enzymes of Schistosoma mansoni: Nucleoside Diphosphate Kinase and Adenylosuccinate Lyase as New Antigenic Targets Against Schistosomiasis., PMID:33072110
The CRISPR-Cas9 crATIC HeLa transcriptome: Characterization of a novel cellular model of ATIC deficiency and ZMP accumulation., PMID:32939338
In silico Metabolic Pathway Analysis Identifying Target Against Leishmaniasis - A Kinetic Modeling Approach., PMID:32211028
Adenylosuccinate lyase hydroxylation contributes to triple negative breast cancer via the activation of cMYC., PMID:32158921
Prolyl hydroxylase substrate adenylosuccinate lyase is an oncogenic driver in triple negative breast cancer., PMID:31729379
Effects of the MC4R, CAPN1, and ADSL genes on body weight and purine content in slow-growing chickens., PMID:31111951
An integrative approach using systems biology, mutational analysis with molecular dynamics simulation to challenge the functionality of a target protein., PMID:30891955
Comparative transcriptome analysis of skeletal muscle in ADSSL1 myopathy., PMID:30853170
Purine Homeostasis Is Necessary for Developmental Timing, Germline Maintenance and Muscle Integrity in Caenorhabditis elegans., PMID:30700528
Molecular comparison of Neanderthal and Modern Human adenylosuccinate lyase., PMID:30573755
Association of ADSL gene polymorphisms with meat quality and carcass traits in domestic pigeons (Columba livia)., PMID:29963908
Proteomics of Stored Red Blood Cell Membrane and Storage-Induced Microvesicles Reveals the Association of Flotillin-2 With Band 3 Complexes., PMID:29780325
Adenylosuccinate lyase enhances aggressiveness of endometrial cancer by increasing killer cell lectin-like receptor C3 expression by fumarate., PMID:29467457
Structural and kinetic analysis of Schistosoma mansoni Adenylosuccinate Lyase (SmADSL)., PMID:28347672
Associations between inflammation-related biomarkers and depressive symptoms in individuals with recently diagnosed type 1 and type 2 diabetes., PMID:28041985
Analysis of extended haplotype in Korean cattle (Hanwoo) population., PMID:27470211
The nonessentiality of essential genes in yeast provides therapeutic insights into a human disease., PMID:27440870
Adenylosuccinate lyase deficiency., PMID:25112391
Fumaric acid production by Torulopsis glabrata: engineering the urea cycle and the purine nucleotide cycle., PMID:25060134
Modulation of de novo purine biosynthesis leads to activation of AMPK and results in improved glucose handling and insulin sensitivity., PMID:24855629
For research use only. Not for human or drug use.
