Catalog No.
YHD90501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ile219-Met420
Predicted molecular weight
23.67 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P30613
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PKL, PK1, Red cell/liver pyruvate kinase, Pyruvate kinase 1, Pyruvate kinase isozymes L/R, PKLR, R-type/L-type pyruvate kinase, Pyruvate kinase PKLR
The sphingosine-1-phosphate receptor 2 S1PR2 mediates chronic glucocorticoid exposure-induced hepatic steatosis and hypertriglyceridemia., PMID:40490140
Dietary Insulinogenic Amino Acid Restriction Improves Glucose Metabolism in a Neonatal Piglet Model., PMID:40431415
USP7 promotes the malignant progression of osteosarcoma through the KPNA2/PKLR axis., PMID:40250695
Glucose and Insulin Differently Regulate Gluconeogenic and Ureagenic Gene Expression., PMID:40024748
Integrative Bioinformatics and Experimental Validation Reveal the Mechanistic Action of Patchouli Alcohol in Prostate Cancer Treatment., PMID:39844397
Transcriptome Analysis Reveals Sertoli Cells Adapting Through Redox and Metabolic Pathways Under Heat Stress in Goats., PMID:39766849
Case report: Modified transplantation for pediatric patients with pyruvate kinase deficiency., PMID:39635530
Integrative analysis of non12-hydroxylated bile acid revealed the suppressed molecular map of alternative pathway in nonalcoholic steatohepatitis mice., PMID:39556333
FT-4202, a selective pyruvate kinase R activator for sickle cell disease., PMID:39549740
Exploring the Molecular Mechanisms underlying SADI-S Improves Glucose Metabolism in Type 2 Diabetic Rats through Liver Transcriptomics and Proteomics Analysis., PMID:39499038
Study on the signaling pathways involved in the anti-hyperglycemic effect of raspberry ketone on zebrafish using integrative transcriptome and metabolome analyses., PMID:39189875
Comorbidities and complications in adult and paediatric patients with pyruvate kinase deficiency: Analysis from the Peak Registry., PMID:39118415
Hypoxia-related signature to risk stratify patients for the benefit of immune checkpoint inhibitors therapy in head and neck squamous cell carcinoma: An experimental study., PMID:39093745
Pyruvate kinase deficiency in 29 Turkish patients with two novel intronic variants., PMID:38811201
Design and synthesis of novel JNK inhibitors targeting liver pyruvate kinase for the treatment of non-alcoholic fatty liver disease and hepatocellular carcinoma., PMID:38714117
PKLR mutations in pyruvate kinase deficient Polish patients: Functional characteristics of c.101-1G > A and c.1058delAAG variants., PMID:38581917
Pyruvate kinase deficiency and PKLR gene mutations: Insights from molecular dynamics simulation analysis., PMID:38434380
Open MoA: revealing the mechanism of action (MoA) based on network topology and hierarchy., PMID:37930015
Biphosphoglycerate Mutase: A Novel Therapeutic Target for Malaria?, PMID:37827586
Enhanced ileum function in weaned piglets via Laminaria digitata and alginate lyase dietary inclusion: A combined proteomics and metabolomics analysis., PMID:37775079
Analysis of the role of glucose metabolism-related genes in dilated cardiomyopathy based on bioinformatics., PMID:37559624
Sequential Activations of ChREBP and SREBP1 Signals Regulate the High-Carbohydrate Diet-Induced Hepatic Lipid Deposition in Gibel Carp (Carassius gibelio)., PMID:37520290
Clinical outcome and genotype analysis of four Chinese children with pyruvate kinase deficiency., PMID:37466302
Proteome Landscapes of Human Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma., PMID:37353004
Computational analysis of non-synonymous single nucleotide polymorphism in the bovine PKLR geneComputational analysis of bovine PKLR gene., PMID:37278385
Bioinformatics identification of prognostic genes and potential interaction analysis in renal cell carcinoma., PMID:37180655
Targeting PKLR/MYCN/ROMO1 signaling suppresses neuroendocrine differentiation of castration-resistant prostate cancer., PMID:36963289
Targeted next-generation sequencing identifies eighteen novel mutations expanding the molecular and clinical spectrum of PKLR gene disorders in the Indian population., PMID:36892591
Data Mining Evidences Variabilities in Glucose and Lipid Metabolism among Fish Strains: A Case Study on Three Genotypes of Gibel Carp Fed by Different Carbohydrate Sources., PMID:36860980
Clinical utility of targeted next-generation sequencing panel in routine diagnosis of hereditary hemolytic anemia: A national reference laboratory experience., PMID:36825813
The Influence of the FFAR4 Agonist TUG-891 on Liver Steatosis in ApoE-Knockout Mice., PMID:36705799
Metabolic heterogeneity in early-stage lung adenocarcinoma revealed by RNA-seq and scRNA-seq., PMID:36692643
FLI1 accelerates leukemogenesis through transcriptional regulation of pyruvate kinase-L/R and other glycolytic genes., PMID:36586017
Ubiquitin-specific protease 3 facilitates cell proliferation by deubiquitinating pyruvate kinase L/R in gallbladder cancer., PMID:36180571
An evaluation of mitapivat for the treatment of hemolytic anemia in adults with pyruvate kinase deficiency., PMID:36124781
Genetic polymorphisms of PKLR gene and their associations with milk production traits in Chinese Holstein cows., PMID:36118870
Haematological profile of malaria patients with G6PD and PKLR variants (erythrocytic enzymopathies): a cross-sectional study in Thailand., PMID:36038921
Antioxidant Therapy Significantly Attenuates Hepatotoxicity following Low Dose Exposure to Microcystin-LR in a Murine Model of Diet-Induced Non-Alcoholic Fatty Liver Disease., PMID:36009344
Novel Drug Candidate Prediction for Intrahepatic Cholangiocarcinoma via Hub Gene Network Analysis and Connectivity Mapping., PMID:35805055
Novel Compound Heterozygous PKLR Mutation Induced Pyruvate Kinase Deficiency With Persistent Pulmonary Hypertension in a Neonate: A Case Report., PMID:35557523
Concomitant Hereditary Spherocytosis and Pyruvate Kinase Deficiency in a Spanish Family with Chronic Hemolytic Anemia: Contribution of Laser Ektacytometry to Clinical Diagnosis., PMID:35406697
Pyruvate kinase L/R links metabolism dysfunction to neuroendocrine differentiation of prostate cancer by ZBTB10 deficiency., PMID:35306527
Hypothalamic-pituitary-adrenal axis activation and glucocorticoid-responsive gene expression in skeletal muscle and liver of Apc mice., PMID:35277933
Genetic variants of PKLR are associated with acute pain in sickle cell disease., PMID:35271708
A novel homozygous missense variant p.D339N in the PKLR gene correlates with pyruvate kinase deficiency in a Pakistani family: a case report., PMID:35168679
Alpha-solanine Anti-tumor Effects in Non-small Cell Lung Cancer Through Regulating the Energy Metabolism Pathway., PMID:35049438
Tissue-specific responses that constrain glucose oxidation and increase lactate production with the severity of hypoxemia in fetal sheep., PMID:34957858
A retinoic acid receptor β2 agonist attenuates transcriptome and metabolome changes underlying nonalcohol-associated fatty liver disease., PMID:34688661
Extracellular vesicle-mediated communication between hepatocytes and natural killer cells promotes hepatocellular tumorigenesis., PMID:34601133
Clinically relevant gene editing in hematopoietic stem cells for the treatment of pyruvate kinase deficiency., PMID:34485608
For research use only. Not for human or drug use.
