Catalog No.
YHD90101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Lys114
Predicted molecular weight
39.45 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P30550
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
GRP-preferring bombesin receptor, GRP-R, GRPR, Gastrin-releasing peptide receptor
Design, Synthesis, and Evaluation of New 2-Arylpropanoic Acid-l-Tryptophan Derivatives for Mitigating Cisplatin-Induced Nephrotoxicity., PMID:40509291
Targeting GRPR for sex hormone-dependent cancer after loss of E-cadherin., PMID:40500450
First-in-Human Serum Stability Studies of [177Lu]Lu-AMTG: A Step Toward Improved GRPR-Targeted Radiopharmaceutical Therapy., PMID:40306971
The evolving role of positron emission tomography in precision prostate cancer biopsy., PMID:40265741
Gastrin-releasing peptide receptor: a promising new biomarker to identify cervical precursor lesions and cancer., PMID:40242010
Cannabinoid CB2 receptor controls chronic itch by regulating spinal microglial activation and synaptic transmission., PMID:40222011
Using mpMRI, PSMA, and GRPR PET to Assess Focal Therapy Eligibility and Plan Treatment in Biopsy-proven Low-/Intermediate-risk Prostate Cancer: A Whole-mount Pathology-based Study., PMID:40179293
Choice of an Optimal Modular Strategy for the Synthesis of DOTA-Containing Heterobivalent Agents Targeting PSMA and GRPr., PMID:40176353
Characterization and targeting of the endosomal signaling of the gastrin releasing peptide receptor in pruritus., PMID:40166294
Diagnostic Potential of 68Ga-NeoB PET/CT with Estrogen Receptor- and Progesterone Receptor-Positive Breast Cancer Undergoing Staging or Restaging for Metastatic Disease., PMID:40147847
Tackling Prostate Cancer with Theranostic E5B9-Bombesin Target Modules (TMs): From Imaging to Treatment with UniCAR T-Cells., PMID:40141329
Evidence Showing Bombesin-Like Peptides Contract Guinea Pig Vas Deferens Smooth Muscle., PMID:40128924
[113mIn]In-AMBA: A Novel Diagnostic Agent for SPECT Imaging of GRPR-Expressing Tumors., PMID:40125027
18 F-FDG PET/CT Positive and 68 Ga-DOTA-Bombesin PET/CT Negative Focus of Benign Apocrine Metaplasia Mimicking Malignancy., PMID:40025668
Design and Synthesis of 68Ga-Labeled Peptide-Based Heterodimers for Dual Targeting of NTS1 and GRPR., PMID:39908060
Radiotheranostic landscape: A review of clinical and preclinical development., PMID:39891713
Clinical Trials in Cancer Theranostics with Potential Near-Term Impact on Clinical Practice., PMID:39873742
Downregulation of the NPY-Y1R system in Grpr neurons results in mechanical and chemical hyperknesis in chronic itch., PMID:39827968
GRPR Drives Metastasis via CRABP2 and FNDC4 Pathways in Lung Adenocarcinoma., PMID:39768218
[113mIn]In-RM2: a high potential agent for SPECT imaging of GRPR-expressing tumors., PMID:39760843
Deciphering the effects of radiopharmaceutical therapy in the tumor microenvironment of prostate cancer: an in-silico exploration with spatial transcriptomics., PMID:39629134
Mechanism of medical hemorrhoid gel in relieving pruritus ani via inhibiting the activation of JAK2/STAT3 pathway., PMID:39606625
Synthesis and Evaluation of 68Ga- and 177Lu-Labeled [Pro14]bombesin(8-14) Derivatives for Detection and Radioligand Therapy of Gastrin-Releasing Peptide Receptor-Expressing Cancer., PMID:39460729
Gastrin-releasing peptide receptor as theranostic target in estrogen-receptor positive breast cancer: A preclinical study of the theranostic pair [55Co]Co- and [177Lu]Lu-DOTA-RM26., PMID:39357076
Preclinical Investigation of [212Pb]Pb-DOTAM-GRPR1 for Peptide Receptor Radionuclide Therapy in a Prostate Tumor Model., PMID:39327021
Kappa opioids inhibit spinal output neurons to suppress itch., PMID:39321286
Detection rate of gastrin-releasing peptide receptor (GRPr) targeted tracers for positron emission tomography (PET) imaging in primary prostate cancer: a systematic review and meta-analysis., PMID:39287742
Evaluation of ABD-Linked RM26 Conjugates for GRPR-Targeted Drug Delivery., PMID:39220525
Radiopharmaceuticals Targeting Gastrin-Releasing Peptide Receptor for Diagnosis and Therapy of Prostate Cancer., PMID:39219355
Synthesis and Evaluation of the First 68Ga-Labeled C-Terminal Hydroxamate-Derived Gastrin-Releasing Peptide Receptor-Targeted Tracers for Cancer Imaging with Positron Emission Tomography., PMID:38999054
Spinal histamine H4 receptor mediates chronic pruritus via p-ERK in acetone-ether-water (AEW)-induced dry skin mice., PMID:38973249
Gastrin Releasing Peptide Receptors-targeted PET Diagnostics and Radionuclide Therapy for Prostate Cancer Management: Preclinical and Clinical Developments of the Past 5 Years., PMID:38644111
IL-6 Enhances the Activation of PI3K-AKT/mTOR-GSK-3β by Upregulating GRPR in Hippocampal Neurons of Autistic Mice., PMID:38536552
Gastrin-releasing peptide receptor (GRPR) as a novel biomarker and therapeutic target in prostate cancer., PMID:38442298
68Ga-RM2 PET-MRI versus MRI alone for evaluation of patients with biochemical recurrence of prostate cancer: a single-centre, single-arm, phase 2/3 imaging trial., PMID:38423030
Synthesis, preclinical, and initial clinical evaluation of integrin αVβ3 and gastrin-releasing peptide receptor (GRPR) dual-targeting radiotracer [68Ga]Ga-RGD-RM26-03., PMID:38376806
Gastrin-releasing peptide receptor as a theranostic target in breast cancer: a systematic scoping review., PMID:38342656
Molecularly Targeted Lanthanide Nanoparticles for Cancer Theranostic Applications., PMID:38334567
Advances of radiolabeled GRPR ligands for PET/CT imaging of cancers., PMID:38279185
Lower-grade gliomas surgery guided by GRPR-targeting PET/NIR dual-modality image probe: a prospective and single-arm clinical trial., PMID:38169486
Synaptic circuits involving gastrin-releasing peptide receptor-expressing neurons in the dorsal horn of the mouse spinal cord., PMID:38143564
Preclinical Evaluation of Gastrin-Releasing Peptide Receptor Antagonists Labeled with 161Tb and 177Lu: A Comparative Study., PMID:38124121
GRP/GRPR signaling pathway aggravates hyperuricemia-induced renal inflammation and fibrosis via ABCG2-dependent mechanisms., PMID:38084678
RNA-seq analysis revealed genes associated with neuropathic pain induced by chronic compressive injury in interferon regulatory factors 4 knockout mice., PMID:38073479
Radiometal Complexes as Pharmacokinetic Modifiers: A Potent 68Ga-Labeled Gastrin-Releasing Peptide Receptor Antagonist Based on the Macrocyclic Metal Chelator NODIA-Me., PMID:37978936
Preclinical Comparison of the 64Cu- and 68Ga-Labeled GRPR-Targeted Compounds RM2 and AMTG, as Well as First-in-Humans [68Ga]Ga-AMTG PET/CT., PMID:37934025
Xanthotoxol relieves itch in mice via suppressing spinal GRP/GRPR signaling., PMID:37871763
Zhenxin Anshen formula ameliorates atopic der-matitis-like skin dysfunction in mice and regulation of transient receptor potential vanilloid 1 and transient receptor potential ankyrin 1 in Neural pathways., PMID:37679976
The Balance Between the Therapeutic Efficacy and Safety of [177Lu]Lu-NeoB in a Preclinical Prostate Cancer Model., PMID:37640941
GRPR down-regulation inhibits spermatogenesis through Ca2+ mediated by PLCβ/IP3R signaling pathway in long-term formaldehyde-exposed rats., PMID:37604300
For research use only. Not for human or drug use.
