Catalog No.
YHD17901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Asn207
Predicted molecular weight
23.96 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P16455
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
MGMT, 6-O-methylguanine-DNA methyltransferase, Methylated-DNA--protein-cysteine methyltransferase, O-6-methylguanine-DNA-alkyltransferase
A Metal-Phenolic Network Nanoresensitizer Overcoming Glioblastoma Drug Resistance through the Metabolic Adaptive Strategy and Targeting Drug-Tolerant Cells., PMID:40489242
Spherical Nucleic Acids as Modulators of CRISPR/Cas12a by a Steric Barrier Effect for Designing Versatile Biosensors., PMID:40469012
Beyond the Promoter: Total MGMT Gene Methylation Modulates Response to DNA Alkylating Agents in Glioma., PMID:40464417
Defining the recommended gray zone in O6-methylguanine-DNA methyltransferase promoter methylation pyrosequencing reporting: A robust, translatable method to implement new EANO guidelines., PMID:40444102
Signaling Pathways in Gliomas., PMID:40428422
All-Trans Retinoic Acid Induces Differentiation and Downregulates Stemness Markers and MGMT Expression in Glioblastoma Stem Cells., PMID:40422249
Multiparametric radiomics signature for predicting molecular genotypes in adult-type diffuse gliomas utilizing 18F-FET PET/MRI., PMID:40420017
Identifying active and inhibitor-resistant MGMT variants for gene therapy., PMID:40398419
The DNA Repair Protein MGMT Protects against the Genotoxicity of N-Nitrosodimethylamine, but Not N-Nitrosodiethanolamine and N-Nitrosomethylaniline, in Human HepG2 Liver Cells with CYP2E1 Expression., PMID:40390554
IDH mutation and MGMT methylation status in glioblastoma and other gliomas patients: a Russian retrospective cohort study., PMID:40377745
Glioblastoma multiforme: an updated overview of temozolomide resistance mechanisms and strategies to overcome resistance., PMID:40353925
Blood group O attributes to prolonged progression-free survival, overall survival, and 5-year survival in isocitrate dehydrogenase-wildtype glioblastoma patients with MGMT promoter methylation., PMID:40351837
A quantitative characterization of the heterogeneous response of glioblastoma U-87 MG cell line to temozolomide., PMID:40341226
Brain-targeted polymersomes mediating RNAi of STAT3 sensitize glioblastoma to temozolomide and immunotherapy., PMID:40339287
Sex-related Survival Differences in Patients With Glioblastoma - Results From a Retrospective Analysis., PMID:40295065
ATRX, OLIG2, MGMT, and IDH2 in Glioblastoma: Essential Molecular Mechanisms and Therapeutic Significance., PMID:40282990
Metabolic reprogramming in glioblastoma: a rare case of recurrence to scalp metastasis., PMID:40274950
Integrative analysis reveals key molecular mechanisms and prognostic model for Ethylnitrosourea-induced gliomagenesis., PMID:40264162
Temporal Muscle Thickness as a Prognostic Marker in a Real-Life Cohort of Newly Diagnosed MGMT Promoter Methylated Glioblastoma: A Multicentric Imaging Analysis., PMID:40260649
Study on the mechanism of action of the active ingredient of Calculus Bovis in the treatment of sepsis by integrating single-cell sequencing and machine learning., PMID:40258762
Analytical validation of the Belay Vantage™ assay for evaluation of MGMT promoter methylation using enzymatically converted tumorDNA from cerebrospinal fluid., PMID:40250264
Association of Intergenic and Intragenic MGMT Enhancer Methylation with MGMT Promoter Methylation, MGMT Protein Expression and Clinical and Demographic Parameters in Glioblastoma., PMID:40244270
Centromere protein A knockdown inhibits rectal cancer through O6-methylguanine DNA methyltransferase/protein tyrosine phosphatase nonreceptor type 4 axis., PMID:40235876
ADAM12 promotes temozolomide resistance in glioblastoma by activating the TNF-α - NF-κB pathway., PMID:40180114
Constitutional Epimutations: From Rare Events Toward Major Cancer Risk Factors?, PMID:40179326
A predictive model for MGMT promoter methylation status in glioblastoma based on terahertz spectral data., PMID:40164371
DNA Damage Response and Repair Genes and Anthracycline-Induced Cardiomyopathy in Childhood Cancer Survivors: A Report From the Children's Oncology Group and the Childhood Cancer Survivor Study., PMID:40151933
Imipridones ONC201/ONC206 + RT/TMZ triple (IRT) therapy reduces intracranial tumor burden, prolongs survival in orthotopic IDH-WT GBM mouse model, and suppresses MGMT., PMID:40145650
Natural small molecule thymoquinone increases the chemosensitivity of glioblastoma to temozolomide through inhibiting Wnt/β-catenin signaling pathway to downregulate MGMT expression: In vitro and in vivo validation., PMID:40127739
Correlation between levels of clock protein expression and effects on temozolomide-resistant glioblastoma and tumor progression., PMID:40123038
α-synuclein expression in glioblastoma restores tumor suppressor function and rescues temozolomide drug resistance., PMID:40108111
Notch1 and Major Vault Proteins Modulate Temozolomide Resistance in Glioblastoma., PMID:40100070
Multi-omic analysis of SDHB-deficient pheochromocytomas and paragangliomas identifies metastasis and treatment-related molecular profiles., PMID:40097403
Detection of O6-methylguanine-DNA methyltransferase gene methylation status in IDH-wild type glioblastomas using methylation-specific qPCR: a first report from Morocco., PMID:40093343
Neoadjuvant triplet immune checkpoint blockade in newly diagnosed glioblastoma., PMID:40016450
Novel Pathways of Oxidative and Nitrosative Inactivation of the Human MGMT Protein in Colon Cancer and Glioblastoma Cells: Increased Efficacy of Alkylating Agents In Vitro and In Vivo., PMID:39997039
Levels of Proangiogenic Molecules and Terminal Complement Complex C5b-9 in the Crown of Circulating sEVs in Patients with Recurrent Glioblastomas: Relationship with Tumor Molecular Characteristics., PMID:39996852
Development of Syngeneic Murine Glioma Models with Somatic Mismatch Repair Deficiency to Study Therapeutic Responses to Alkylating Agents and Immunotherapy., PMID:39995104
Predictive modeling with linear machine learning can estimate glioblastoma survival in months based solely on MGMT-methylation status, age and sex., PMID:39992425
MGMT epimutations and risk of incident cancer of the colon, glioblastoma multiforme, and diffuse large B cell lymphomas., PMID:39980037
Discovery of a novel Wnt inhibitor DK419: Reversing temozolomide resistance in glioblastoma by switching off Wnt/β-catenin signaling pathway to inhibit MGMT expression., PMID:39978109
Glycosylated Delphinidins Decrease Chemoresistance to Temozolomide by Regulating NF-κB/MGMT Signaling in Glioblastoma., PMID:39936970
Bioinformatics insights into ACSL1 and ACSL5: prognostic and immune roles in low-grade glioma., PMID:39924494
Impact of developmental state, p53 status, and interferon signaling on glioblastoma cell response to radiation and temozolomide treatment., PMID:39919036
Treatment practices and survival outcomes for IDH-wildtype glioblastoma patients according to MGMT promoter methylation status: insights from the U.S. National Cancer Database., PMID:39907975
Validating a clinically based MS-MLPA threshold through comparison with Sanger sequencing in glioblastoma patients., PMID:39881389
Temozolomide-Promoted MGMT Transcription Contributes to Chemoresistance by Activating the ERK Signalling Pathway in Malignant Melanoma., PMID:39873425
Deep learning classification of MGMT status of glioblastomas using multiparametric MRI with a novel domain knowledge augmented mask fusion approach., PMID:39863759
Advanced Distance-Resolved Evaluation of the Perienhancing Tumor Areas with FLAIR Hyperintensity Indicates Different ADC Profiles by MGMT Promoter Methylation Status in Glioblastoma., PMID:39848779
Aberrant DNA methylation of EDNRB, MGMT and TIMP3 gene promoters in saliva of head and neck carcinoma patients as a diagnostic tool., PMID:39847241
For research use only. Not for human or drug use.
